Pd(II)-Catalyzed ortho-C–H Olefination/Dearomatization of N‑Aryl Ureas: An Approach to Imine Derivatives

Dataset UNKNOWN
Jiang, Pingping; Xu, Yongbao; Sun, Fuxing; Liu, Xufei; Li, Feng; Yu, Renfu; Li, Yang; Wang, Qifeng;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.orglett.6b00363.s004, doi: 10.1021/acs.orglett.6b00363.s003, doi: 10.1021/acs.orglett.6b00363.s002
  • Subject: Molecular Biology | synthesis | dearomatization | Mechanistic investigation | migration process | approach | Fused ring products | regioselective | Urea | 20 examples | Pd | Biochemistry | yield | palladium | alkyne | spirocyclic imine derivatives | Biophysics | naphthyl | Imine Derivatives | substrate | Olefination
    • FOR: 29999 Physical Sciences not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

An unprecedented approach for the synthesis of imine derivatives was achieved via a Pd­(II)-catalyzed dearomatization reaction of <i>N</i>-aryl ureas with internal alkynes. The corresponding spirocyclic imine derivatives were obtained with 20 examples in good t... View more
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