Aluminum-Catalyzed Asymmetric Alkylations of Pyridyl-Substituted Alkynyl Ketones with Dialkylzinc Reagents

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Friel, Donna K.; Snapper, Marc L.; Hoveyda, Amir H.;
(2008)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/ja802935w.s002, doi: 10.1021/ja802935w.s001
  • Subject: Molecular Biology | Biotechnology | chiral ligand | acid | Ecology | Et 2 Zn | Genetics | Evolutionary Biology | quaternary carbon stereogenic center | Dialkylzinc Reagents Alkylations | 2 Zn | Biochemistry | Pharmacology | propargyl alcohols | presence | Biophysics | Immunology
    • FOR: 111714 Mental Health | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: heterocyclic compounds | organic chemicals

Alkylations of pyridyl-substituted ynones with Et<sub>2</sub>Zn and Me<sub>2</sub>Zn, promoted by amino acid-based chiral ligands in the presence of Al-based alkoxides, afford tertiary propargyl alcohols efficiently in 57% to >98% ee. Two easily accessible chiral ligand... View more
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