Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor

Audiovisual UNKNOWN
Jakowiecki, Jakub; Filipek, Slawomir;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.jcim.6b00499.s002, doi: 10.1021/acs.jcim.6b00499.s003
  • Subject: Molecular Biology | ligand entrance pathway | CB 1 receptor | SMD | CB 1 Cannabinoid Receptor | Pharmacology | Hydrophobic Ligand Entry | Biophysics | CB 1 ligand binding | G-protein-coupled receptors access | TM 2 helix | CB 1 agonists | alternative binding site | helices TM 4 | TM 7 | Medicine | THC | Computational Biology | Cell Biology | residues F 174 2.61 | F 177 2.64 | Biochemistry | bulk water
    • FOR: 29999 Physical Sciences not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: mental disorders

It has been reported that some hydrophobic ligands of G-protein-coupled receptors access the receptor’s binding site from the membrane rather than from bulk water. In order to identify the most probable ligand entrance pathway into the CB1 receptor, we perfo... View more
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