Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms

Dataset UNKNOWN
Picconi, Pietro; Hind, Charlotte; Jamshidi, Shirin; Nahar, Kazi; Clifford, Melanie; Wand, Matthew E.; Mark Sutton, J.; Rahman, Khondaker Miraz;
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.jmedchem.7b00108.s002, doi: 10.1021/acs.jmedchem.7b00108.s003
  • Subject: Biotechnology | MIC | Resistant Pathogenic Microorganisms | bactericidal mode | Compound 13 | Ecology | Molecular modeling experiments | triaryl benzimidazole compounds | Enterococci species | Antibacterial Agents | DNA | MDR Staphylococci | Gram-negative species | Triaryl Benzimidazoles | Microbiology | Compounds 8 | Medicine | chemical class | groove binders | Cell Biology | modeling study | Biochemistry | New Class | MOA
    • FOR: 59999 Environmental Sciences not elsewhere classified | 110309 Infectious Diseases | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

A new class of nontoxic triaryl benzimidazole compounds, derived from existing classes of DNA minor groove binders, were designed, synthesized, and evaluated for their antibacterial activity against multidrug resistant (MDR) Gram-positive and Gram-negative s... View more
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