Phosphate Tether-Mediated Ring-Closing Metathesis for the Generation of P‑Stereogenic, Z‑Configured Bicyclo[7.3.1]- and Bicyclo[8.3.1]phosphates

Markley, Jana L.; Maitra, Soma; Hanson, Paul R.;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.joc.5b02473.s003, doi: 10.1021/acs.joc.5b02473.s004
  • Subject: Molecular Biology | RCM event | macrocyclic phosphates | stereochemical outcome | Microbiology | Physiology | olefin | utility | Computational Biology | Marine Biology | bridgehead carbon | Bicyclo | Evolutionary Biology | Biochemistry | Science Policy
    • FOR: 59999 Environmental Sciences not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

A phosphate tether-mediated ring-closing metathesis (RCM) study to the synthesis of <i>Z</i>-configured, <i>P</i>-stereogenic bicyclo[7.3.1]- and bicyclo[8.3.1]­phosphates is reported. Investigations suggest that C3-substitution, olefin substitution, and pro... View more
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