A Comparison of the Binding Sites of Matrix Metalloproteinases and Tumor Necrosis Factor-α Converting Enzyme:  Implications for Selectivity

Lukacova, Viera; Zhang, Yufen; Kroll, Daniel M.; Raha, Soumyendu; Comez, Dogan; Balaz, Stefan;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jm0491703.s001, doi: 10.1021/jm0491703.s002
  • Subject: binding sites | Specific binding | ADAM | Selectivity MMPs | TACE inhibitors | S 3 subsite | inhibitor atoms | S 2 subsite | Biochemistry | ligand part | Cancer | Immunology | Matrix Metalloproteinases
    • FOR: 39999 Chemical Sciences not elsewhere classified

MMPs and TACE (ADAM-17) assume independent, parallel, or opposite pathological roles in cancer, arthritis, and several other diseases. For therapeutic purposes, selective inhibition of individual MMPs and TACE is required in most cases due to distinct roles in dis... View more
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