Isoinversion Behavior in the Enantioselective Oxidations of Pyridylmethylthiobenzimidazoles to Chiral Proton Pump Inhibitors on Titanium Salalen Complexes

Talsi, Evgenii P.; Rybalova, Tatyana V.; Bryliakov, Konstantin P.;

The oxidation of two pyridylmethylthiobenzimidazoles to proton pump inhibitors (<i>S</i>)-omeprazole and (<i>R</i>)-lansoprazole, and to their enantiomers, with H<sub>2</sub>O<sub>2</sub> is achieved by using chiral titanium salalen complexes as catalysts. The lat... View more
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