Evolution of P450 Monooxygenases toward Formation of Transient Channels and Exclusion of Nonproductive Gases

Audiovisual UNKNOWN
C. J. C. Ebert, Maximilian C.; Dürr, Simon L.; A. Houle, Armande; Lamoureux, Guillaume; Pelletier, Joelle N.;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acscatal.6b02154.s002, doi: 10.1021/acscatal.6b02154.s003
  • Subject: O 2 binding | P 450s CYP 102A | O 2 molecules | BM | Cytochrome P 450 enzymes | Ecology | Genetics | ligand migration channels | O 2 reservoirs | Biophysics | gas migration | S 2 order parameter | gas migration channels | Medicine | evolution | Nonproductive Gases Gaseous molecules | CO | Computational Biology | Biochemistry | P 450 Monooxygenases | protein backbone dynamics | Cancer
    • FOR: 29999 Physical Sciences not elsewhere classified | 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified

Gaseous molecules are essential for biological processes, yet mapping the migration of gas molecules into and out of proteins represents a significant challenge. Cytochrome P450 enzymes (P450s) contain numerous channels thought to be populated by their subst... View more
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