Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human Brain

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Davis, Simon; Scott, Connor; Ansorge, Olaf; Fischer, Roman;
(2019)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.jproteome.8b00981.s003, doi: 10.1021/acs.jproteome.8b00981.s002
  • Subject: Molecular Biology | Biotechnology | Developmental Biology | cell types | Physiology | Medicine | tissue | cell type | 60 000 μ m 2 | proteome | proteomics averages protein abundance | Cell Biology | Genetics | sample collection methods | 10 μ m | Biochemistry | LCM | protein expression gradients | Cancer | Biophysics
    • FOR: 29999 Physical Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

While nearly comprehensive proteome coverage can be achieved from bulk tissue or cultured cells, the data usually lacks spatial resolution. As a result, tissue based proteomics averages protein abundance across multiple cell types and/or localizations. With ... View more
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