Dynamic Kinetic Asymmetric Synthesis of Five Contiguous Stereogenic Centers by Sequential Organocatalytic Stetter and Michael−Aldol Reaction: Enantioselective Synthesis of Fully Substituted Cyclopentanols Bearing a Quaternary Stereocenter

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Hong, Bor-Cherng; Dange, Nitin S.; Hsu, Che-Sheng; Liao, Ju-Hsiou; Lee, Gene-Hsiang;
(2011)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/ol200006e.s002, doi: 10.1021/ol200006e.s005, doi: 10.1021/ol200006e.s003, doi: 10.1021/ol200006e.s004
  • Subject: Molecular Biology | Enantioselective Synthesis | Biotechnology | cyclopentane | Sociology | Plant Biology | Dynamic Kinetic Asymmetric Synthesis | Quaternary StereocenterA synthesis | quaternary carbon center | Ecology | Genetics | Evolutionary Biology | enantioselectivitie | Biophysics | stereogenic centers | ee | sequential organocatalyzed Stetter | heteroaromatic aldehydes | Developmental Biology | Contiguous Stereogenic Centers | Medicine | transformation | Computational Biology | Substituted Cyclopentanols Bearing | annulation | Biochemistry | nitroalkene | strategy | Sequential Organocatalytic Stetter
    • FOR: 110309 Infectious Diseases | 111714 Mental Health | 39999 Chemical Sciences not elsewhere classified

A synthesis of fully substituted cyclopentanes bearing a quaternary carbon center and five contiguous stereogenic centers has been achieved by sequential organocatalyzed Stetter and Michael−Aldol reactions of heteroaromatic aldehydes, nitroalkenes, and α,β-unsaturated a... View more
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