Radical Hydroxyalkylation of C−H Bond Adjacent to Nitrogen of Tertiary Amides, Ureas, and Amines
Yoshimitsu, Takehiko; Arano, Yoshimasa; Nagaoka, Hiroto;
- Publisher: Figshare
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- Subject: Biotechnology | Amines Tertiary amides | Developmental Biology | amines | aldehyde | Adjacent | transformation | Bond | urea | Tertiary Amides | Et | Radical Hydroxyalkylation | Biochemistry | molecule | sp
- FOR: 39999 Chemical Sciences not elsewhere classified
Tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the Et<sub>3</sub>B/air conditions, thereby providing a unique and simple means for the radical sp<sup>3</sup> C−H transformation of nitrogen-containing molecules.
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