Synthesis of Dibenzofurans via Palladium-Catalyzed Phenol-Directed C–H Activation/C–O Cyclization

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Xiao, Bin; Gong, Tian-Jun; Liu, Zhao-Jing; Liu, Jing-Hui; Luo, Dong-Fen; Xu, Jun; Liu, Lei;
(2011)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/ja203335u.s001, doi: 10.1021/ja203335u.s002
  • Subject: synthesis | CyclizationA | method | Microbiology | Medicine | reductive | oxidant | cyclization | dibenzofurans | Computational Biology | Dibenzofuran | Pd | variety | Biochemistry | activation | elimination | Synthesi
    • FOR: 59999 Environmental Sciences not elsewhere classified | 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified

A practical, Pd(0)/Pd(II)-catalyzed reaction was developed for phenol-directed C–H activation/C–O cyclization using air as an oxidant. The turnover-limiting step of the process was found to be C–O reductive elimination instead of C–H activation. This reaction can tolera... View more
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