Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism

Audiovisual UNKNOWN
Lopes, Dahabada H. J.; Attar, Aida; Nair, Gayatri; Hayden, Eric Y.; Du, Zhenming; McDaniel, Kirsten; Dutt, Som; Bravo-Rodriguez, Kenny; Mittal, Sumit; Klärner, Frank-Gerrit; Wang, Chunyu; Sanchez-Garcia, Elsa; Schrader, Thomas; Bitan, Gal;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acschembio.5b00146.s003, doi: 10.1021/acschembio.5b00146.s004, doi: 10.1021/acschembio.5b00146.s002
  • Subject: Molecular Biology | Biotechnology | inhibition | CLR 01 | CLR 01 concentrations | tweezer CLR 01 | Space Science | Cell Biology | Biochemistry | Pharmacology | Cancer | Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly | T 2D islet amyloid polypeptide | CLR 01. | Biophysics | Immunology | IAPP toxicity
    • FOR: 80699 Information Systems not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: endocrine system

In type-2 diabetes (T2D), islet amyloid polypeptide (IAPP) self-associates into toxic assemblies causing islet β-cell death. Therefore, preventing IAPP toxicity is a promising therapeutic strategy for T2D. The molecular tweezer CLR01 is a supramolecular tool... View more
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