Approach to Chiral 1‑Substituted Isoquinolone and 3‑Substituted Isoindolin-1-one by Addition–Cyclization Process

Dataset UNKNOWN
Zhou, Wen; Zhang, Yan-Xue; Nie, Xiao-Di; Si, Chang-Mei; Sun, Xun; Wei, Bang-Guo;
(2018)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.joc.8b01282.s002, doi: 10.1021/acs.joc.8b01282.s001
  • Subject: Molecular Biology | II | Grignard reagents | Developmental Biology | imine | Sociology | approach | Computational Biology | -1-one | NMM | Ecology | Genetics | Evolutionary Biology | Substituted | Biochemistry | Cancer | Biophysics
    • FOR: 59999 Environmental Sciences not elsewhere classified | 19999 Mathematical Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

An approach to access 1-substituted isoquinolones has been developed through the addition–cyclization of imines with Grignard reagents in the presence of 2,2′-dipyridyl. A number of substituted aromatic magnesium reagents were amenable to this process, and t... View more
Share - Bookmark

  • Download from
    figshare via figshare (Dataset, 2018)
  • Cite this research data