Monomeric Polyglutamine Structures That Evolve into Fibrils

Dataset UNKNOWN
Punihaole, David; Jakubek, Ryan S.; Workman, Riley J.; Marbella, Lauren E.; Campbell, Patricia; Madura, Jeffry D.; Asher, Sanford A.;
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.jpcb.7b04060.s004, doi: 10.1021/acs.jpcb.7b04060.s005, doi: 10.1021/acs.jpcb.7b04060.s002, doi: 10.1021/acs.jpcb.7b04060.s003
  • Subject: glutamine side chains | Monomeric Polyglutamine Structures | monomeric Q 10 peptides | energy landscape | PPII | monomeric Q 10 conformations | UVRR | MD | Biophysics | Q 10 | α- helix-like structures | Neuroscience | β- sheet aggregates | activation barrier | D 2 Q 10 K 2 | Computational Biology | β- strand-like conformations | fibril | acetonitrile-rich solutions show morphologies | Biochemistry | UV resonance Raman | Q 10 converts
    • FOR: 29999 Physical Sciences not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

We investigate the solution and fibril conformations and structural transitions of the polyglutamine (polyQ) peptide, D<sub>2</sub>Q<sub>10</sub>K<sub>2</sub> (Q10), by synergistically using UV resonance Raman (UVRR) spectroscopy and molecular dynamics (MD) sim... View more
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