Exploring the Scope of Asymmetric Synthesis of β‑Hydroxy-γ-lactams via Noyori-type Reductions

Lynch, Denis; Deasy, Rebecca E.; Clarke, Leslie-Ann; Slattery, Catherine N.; B. Rao Khandavilli, U.; Lawrence, Simon E.; Maguire, Anita R.; Magnus, Nicholas A.; Moynihan, Humphrey A.;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.orglett.6b02416.s001, doi: 10.1021/acs.orglett.6b02416.s002
  • Subject: Molecular Biology | β- hydroxy -γ-lactams | Biotechnology | ketone substituent | Full conversion | Genetics | diastereoselective hydrogenation | Asymmetric Synthesis | β- keto -γ-lactams | Biochemistry | Pharmacology | bioactive compounds | Noyori-type Reductions Enantio
    • FOR: 80699 Information Systems not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

Enantio- and diastereoselective hydrogenation of β-keto-γ-lactams with a ruthenium–BINAP catalyst, involving dynamic kinetic resolution, has been employed to provide a general, asymmetric approach to β-hydroxy-γ-lactams, a structural motif common to several ... View more
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