Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides

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Arteaga, Fernando Arteaga; Liu, Zijian; Brewitz, Lennart; Chen, Jianyang; Sun, Bo; Kumagai, Naoya; Shibasaki, Masakatsu;
(2016)

Direct enolate formation coupled with subsequent enantioselective C–C bond formation remains a topic of intense interest in asymmetric catalysis. This methodology is achieved even with low acidic amides without an electron-withdrawing group at the α-position... View more
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