Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria

Audiovisual UNKNOWN
Sreedharan, Sreejesh; Gill, Martin R.; Garcia, Esther; Saeed, Hiwa K.; Robinson, Darren; Byrne, Aisling; Cadby, Ashley; Keyes, Tia E.; Smythe, Carl; Pellett, Patrina; Bernardino de la Serna, Jorge; Thomas, Jim A.;

Detailed studies on the live cell uptake properties of a dinuclear membrane-permeable Ru<sup>II</sup> cell probe show that, at low concentrations, the complex localizes and images mitochondria. At concentrations above ∼20 μM, the complex images nuclear DNA. ... View more
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