N‑Arylazetidines: Preparation through Anionic Ring Closure

Dataset UNKNOWN
Quinodoz, Pierre; Drouillat, Bruno; Wright, Karen; Marrot, Jérôme; Couty, François;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.joc.6b00169.s001, doi: 10.1021/acs.joc.6b00169.s002
  • Subject: Molecular Biology | Biotechnology | access | nitrile transformation | azetidine | ring closure | iii | diastereoselectivity | Preparation | mesylation | substitution pattern | Ecology | crystallography | Evolutionary Biology | Anionic Ring Closure | diversely | Pharmacology | Suzuki | Biophysics | Immunology | ii | synthesis | AM 1 calculations | Physiology | derivatization | compound | sequence | enantiomerically | scaffold | Biochemistry | aniline
    • FOR: 59999 Environmental Sciences not elsewhere classified | 29999 Physical Sciences not elsewhere classified | 110309 Infectious Diseases | 39999 Chemical Sciences not elsewhere classified

We report herein an efficient synthesis of diversely substituted <i>N</i>-aryl-2-cyanoazetidines based on an anionic ring-closure reaction. These compounds can be prepared from β-amino alcohols in enantiomerically pure form through a three-step sequence involvi... View more
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