Quantitative Organelle Proteomics of MCF-7 Breast Cancer Cells Reveals Multiple Subcellular Locations for Proteins in Cellular Functional Processes

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Qattan, Amal T.; Mulvey, Claire; Crawford, Mark; Natale, Darren A.; Godovac-Zimmermann, Jasminka;
(2010)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/pr9008332.s002, doi: 10.1021/pr9008332.s003
  • Subject: Molecular Biology | Biotechnology | Cellular Functional ProcessesWe | subcellular locations | breast cancer proteins | Plant Biology | breast cancer | Multiple Subcellular Locations | MCF | Hematology | Cell Biology | Genetics | sucrose density gradient subcellular fractionation | sucrose gradient fractions | 1223 subcellular locations | Biochemistry | Cancer | Biophysics | Quantitative Organelle Proteomics
    • FOR: 29999 Physical Sciences not elsewhere classified | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

We have combined sucrose density gradient subcellular fractionation with quantitative, tandem-mass-spectrometry-based shotgun proteomics to investigate spatial distributions of proteins in MCF-7 breast cancer cells. Emphasis was placed on four major organellar compartme... View more
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