Cascade Oxidation/Halogenoaminocyclization Reaction of Trifluoromethylated Homoallylic N‑Acylhydrazines: Metal-free Synthesis of CF3‑Substituted Pyrazolines

Dataset UNKNOWN
Wang, Yuxiang; Wang, Ke-Hu; Su, Yingpeng; Yang, Zheng; Wen, Lan; Liu, Lili; Wang, Juanjuan; Huang, Danfeng; Hu, Yulai;
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/acs.joc.7b02934.s002, doi: 10.1021/acs.joc.7b02934.s001
  • Subject: Biotechnology | access | pyrazoline compounds | derivative | Metal-free | Genetics | Evolutionary Biology | yield | Science Policy | Pyrazoline | acylhydrazine | Trifluoromethylated | halogen | CF | cascade | oxidation | transformation | additive | Substituted | catalyst | Biochemistry | trifluoromethylated homoallylic N | Homoallylic | Synthesi
    • FOR: 59999 Environmental Sciences not elsewhere classified | 110309 Infectious Diseases | 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

An efficient and practical cascade oxidation/halogenoaminocyclization of trifluoromethylated homoallylic <i>N</i>-acylhydrazines is developed. The protocol enables an efficient access to various biologically interesting CF<sub>3</sub>-containing pyrazoline c... View more
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