Highly Diastereoselective Synthesis of Homoallylic Alcohols Bearing Adjacent Quaternary Centers Using Substituted Allylic Zinc Reagents

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Ren, Hongjun; Dunet, Guillaume; Mayer, Peter; Knochel, Paul;
(2007)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/ja071380s.s001, doi: 10.1021/ja071380s.s002, doi: 10.1021/ja071380s.s003, doi: 10.1021/ja071380s.s004
  • Subject: polysubstituted allylic zinc reagents | Biotechnology | Microbiology | Medicine | Computational Biology | Homoallylic Alcohols Bearing Adjacent Quaternary Centers | Ecology | Cell Biology | diastereoselective synthesis | Biochemistry | Pharmacology | polysubstituted allylic chlorides | Cancer | quaternary centers | homoallylic alcohols | Biophysics | Substituted Allylic Zinc ReagentsStaring | polysubstituted allylic zinc chlorides
    • FOR: 29999 Physical Sciences not elsewhere classified | 111714 Mental Health | 39999 Chemical Sciences not elsewhere classified
    mesheuropmc: food and beverages | organic chemicals

Staring from readily available polysubstituted allylic chlorides, a range of polysubstituted allylic zinc chlorides were obtained using a LiCl-mediated zinc dust insertion in 55−84% yield. A highly diastereoselective synthesis of homoallylic alcohols bearing up to two a... View more
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