3D-QSAR Studies on Cannabinoid CB1 Receptor Agonists:  G-Protein Activation as Biological Data

Salo, Outi M. H.; Savinainen, Juha R.; Parkkari, Teija; Nevalainen, Tapio; Lahtela-Kakkonen, Maija; Gynther, Jukka; Laitinen, Jarmo T.; Järvinen, Tomi; Poso, Antti;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1021/jm0505157.s003, doi: 10.1021/jm0505157.s004, doi: 10.1021/jm0505157.s002
  • Subject: receptor conformer | QSAR models | CB 1 receptor models | CB 1 receptor | activity data | CB 1 ligands | cannabinoid derivatives | alignment models | receptor binding site | Ecology | Cell Biology | Biochemistry | CoMSIA studies | endocannabinoid headgroup | molecules overlap | docking alignment | cannabinoid structures | CoMFA | Immunology
    • FOR: 69999 Biological Sciences not elsewhere classified
    mesheuropmc: lipids (amino acids, peptides, and proteins)

G-protein activation via the CB1 receptor was determined for a group of various CB1 ligands and utilized as biological activity data in subsequent CoMFA and CoMSIA studies. Both manual techniques and automated docking at CB1 receptor models were used to obtain a c... View more
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