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The ECRIN Clinical Research Metadata Repository is a portal allowing users to search for studies using a variety of criteria and identify the data objects (trial registrations, results summaries, journal articles, protocols etc.) associated with them. The repository is intended to support researchers and reviewers locate available data objects of all types, from a wide variety of sources. Where the data is publicly available, links are provided to directly access the data object. For controlled data, links to information about data access are available.

Widespread in nature, sulfated biomolecules are highly diverse in chemical structure and biological function. These compounds include sulfate esters (ROSO3-) and sulfamates (RN(H)SO3-) and range from small molecules to complex polymers. Sulfatases cleave sulfate groups from such molecules and constitute a biologically and industrially important group of enzymes. However, the number of sulfatases which have been characterized is limited in comparison to the huge diversity of the sulfated compounds. In the context of the explosion of genomic data, the functional annotation of sulfatases is thus particularly prone to flaws and misinterpretations. A classification system allowing for a better prediction of substrate specificity and for setting the limit of functional annotations was therefore urgently needed for sulfatases. SulfAtlas describes the family and sub-families of structurally-related sulfatases. Sub-families are created based on phylogenetic analyses and essentially correspond to different substrate specificities. Experimental evidences for the activity of new sulfatases will be regularly updated.

Disciplinary long-term archive for climate and earth system science data

BCL2DB is a database designed to integrate data on BCL-2 family members and BH3-only proteins.

The PlantRNA database compiles tRNA gene sequences retrieved from fully annotated plant nuclear, plastidial and mitochondrial genomes. For each tRNA gene, the linear secondary structure is given as well as biological information. This includes 5'- and 3'- flanking sequences, A and B box sequences, region of transcription initiation and poly(T) transcription termination stretches, tRNA intron sequences, aminoacyl-tRNA synthetases and enzymes responsible for tRNA maturation and modification. Data on mitochondrial import of nuclear-encoded tRNAs as well as the bibliome for the respective tRNAs and tRNA binding proteins are also included.

HOVERGEN is a database of homologous vertebrate genes that allows one to select sets of homologous genes among vertebrate species, and to visualize multiple alignments and phylogenetic trees. Note from the FAIRsharing team: we have classified the status of the resource as 'uncertain' because the link is not working, and we are making every effort to engage with the resource owners to understand if it is a temporary issue or if the resource is no longer active.