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Gene regulation plays a fundamental role in shaping tissue identity, function, and response to perturbation. Regulatory processes are controlled by complex networks of interacting elements, including transcription factors, miRNAs and their target genes. The structure of these networks helps to determine phenotypes and can ultimately influence the development of disease or response to therapy. We developed GRAND (https://grand.networkmedicine.org) as a database for computationally-inferred, context-specific gene regulatory network models that can be compared between biological states, or used to predict which drugs produce changes in regulatory network structure. The database includes 12 468 genome-scale networks covering 36 human tissues, 28 cancers, 1378 unperturbed cell lines, as well as 173 013 TF and gene targeting scores for 2858 small molecule-induced cell line perturbation paired with phenotypic information. GRAND allows the networks to be queried using phenotypic information and visualized using a variety of interactive tools. In addition, it includes a web application that matches disease states to potentially therapeutic small molecule drugs using regulatory network properties.

The Water Quality Portal (WQP) integrates publicly available water quality data from the USGS National Water Information System (NWIS), the EPA STOrage and RETrieval (STORET) Data Warehouse, and the USDA ARS Sustaining The Earth’s Watersheds - Agricultural Research Database System (STEWARDS) .

The Distributed Archives for Neurophysiology Data Integration (DANDI) is a platform for publishing, sharing, and processing neurophysiology data funded by the BRAIN Initiative. The archive accepts cellular neurophysiology data including electrophysiology, optophysiology, and behavioral time-series, and images from immunostaining experiments.

The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains current information on the protein effect of somatic gene variants, but also connects the variant to targeted therapies through an efficacy evidence annotation. In addition, CKB captures clinical trial patient eligibility criteria that include genomic alterations (genotype-specific). The public access version of CKB encompasses 82 commonly known driver genes. Users can search CKB via gene, gene variants, drug, drug class, indication, and clinical trials. The web-based version of CKB is designed to interrogate the knowledgebase for specific data attributes while also enabling a robust browse like feature when the desired content is unknown.

PATRIC is part of the Bacterial Bioinformatics Resource Center, and is an information system designed to support the biomedical research community’s work on bacterial infectious diseases via integration of vital pathogen information with rich data and analysis tools. PATRIC provides an interface for biologists to discover data and information and conduct comprehensive comparative genomics and other analyses. PATRIC includes over 250 000 publicly available microbial genomes and tools for comparative analysis.

The Citrus Genome Database, known as CGD, is a USDA and NSF funded resource to enable basic, translational and applied research in citrus. It houses genomics, genetics and breeding data for citrus species and organisms associated with HLB. It is built by the Mainlab at Washington State University using the open-source, generic database platform Tripal.

UNC Dataverse is a research data repository hosted by the Research Data Management Core at the University of North Carolina at Chapel Hill (UNC). UNC Dataverse is an open access repository that accepts data deposits from UNC-affiliated researchers, research groups, institutions, journals, and other entities from all disciplinary domains. UNC Dataverse offers value-added features that support archiving, discovery, and sharing of research data that align with FAIR principles for findable, accessible, interoperable, reusable data.

The Vaccine Investigation and Online Information Network (VIOLIN) is a web-based central resource that integrates vaccine literature data mining, vaccine research data curation and storage, and curated vaccine data analysis for vaccines and vaccine candidates developed against various pathogens of high priority in public health and biological safety. The vaccine data includes research data from vaccine studies using humans, natural and laboratory animals. VIOLIN annotates, extracts and stores vaccine-related, peer-reviewed papers from PubMed. The curated vaccine-related information contains many categories such as general pathogenesis, protective immunity, vaccine preparation and characteristics, host responses including vaccination protocol and efficacy against virulent pathogen infections. All data within the database is edited manually and is derived primarily from peer-reviewed publications. The curated data is stored in a relational database and can be queried using various VIOLIN search programs.

CAS (Chemical Abstracts Service) Common Chemistry is an open community resource for accessing chemical information. Nearly 500,000 chemical substances from the CAS REGISTRY cover areas of community interest, including common and frequently regulated chemicals, and those relevant to high school and undergraduate chemistry classes. This chemical information is manually curated and provided in alignment with their role as a division of the American Chemical Society.

In 2007, ISKME launched OER Commons, its digital public library and collaboration platform, informed by the organization's pioneering efforts in knowledge management and educational innovation. OER Commons offers a comprehensive infrastructure for curriculum experts and instructors at all levels to identify high-quality OER and collaborate around their adaptation, evaluation, and use to address the needs of teachers and learners. Diving into OER Commons is an exciting opportunity to collaborate with other educators and learners, at the forefront of a new educational era.