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The Omics Discovery Index (OmicsDI) provides dataset discovery across a heterogeneous, distributed group of Transcriptomics, Genomics, Proteomics and Metabolomics data resources, including both open and controlled access data resources. The resource provides a short description of every dataset, including accession, description, sample/data protocols biological evidences, and publication. Based on these metadata, OmicsDI provides extensive search capabilities, as well as identification of related datasets by metadata and data content where possible. In particular, OmicsDI identifies groups of related, multi-omics datasets across repositories by shared identifiers.

HIstome (Human histone database) is a freely available, specialist, electronic database dedicated to display information about human histone variants, sites of their post-translational modifications and about various histone modifying enzymes.

Expasy is the bioinformatics resource portal of the SIB Swiss Institute of Bioinformatics. It is an extensible and integrative portal which provides access to over 160 databases and software tools, developed by SIB Groups and supporting a range of life science and clinical research domains, from genomics, proteomics and structural biology, to evolution and phylogeny, systems biology and medical chemistry.

EnviDat is the WSL data portal providing unified and managed access to environmental monitoring and research data. The portal has the capability to host and publish data sets. Through the sharing of unique and high-value data sets worldwide, EnviDat fosters research and contributes to advancing environmental science. EnviDat is the official institutional data repository of WSL.

PsoProtect is an international registry for health care providers to report outcomes of COVID-19 in individuals with psoriasis. It provides regular, open access summaries of all reported cases, for the benefit of the international psoriasis community.

Gene regulation plays a fundamental role in shaping tissue identity, function, and response to perturbation. Regulatory processes are controlled by complex networks of interacting elements, including transcription factors, miRNAs and their target genes. The structure of these networks helps to determine phenotypes and can ultimately influence the development of disease or response to therapy. We developed GRAND (https://grand.networkmedicine.org) as a database for computationally-inferred, context-specific gene regulatory network models that can be compared between biological states, or used to predict which drugs produce changes in regulatory network structure. The database includes 12 468 genome-scale networks covering 36 human tissues, 28 cancers, 1378 unperturbed cell lines, as well as 173 013 TF and gene targeting scores for 2858 small molecule-induced cell line perturbation paired with phenotypic information. GRAND allows the networks to be queried using phenotypic information and visualized using a variety of interactive tools. In addition, it includes a web application that matches disease states to potentially therapeutic small molecule drugs using regulatory network properties.

The MIBiG (Minimum Information about a Biosynthetic Gene Cluster) Repository stores Biosynthetic Gene Clusters (BGC) that are manually curated through community efforts. It is a central reference database for BGCs of known function, and provides the basis for comparative analyses for a number of tools. It has enabled many computational analyses of BGC function and novelty central to both small and large-scale studies of microbes and microbial communities.

The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains current information on the protein effect of somatic gene variants, but also connects the variant to targeted therapies through an efficacy evidence annotation. In addition, CKB captures clinical trial patient eligibility criteria that include genomic alterations (genotype-specific). The public access version of CKB encompasses 82 commonly known driver genes. Users can search CKB via gene, gene variants, drug, drug class, indication, and clinical trials. The web-based version of CKB is designed to interrogate the knowledgebase for specific data attributes while also enabling a robust browse like feature when the desired content is unknown.

GlyConnect is a knowledgebase of glycoproteins spanning protein, glycosite and glycan information. It is a platform designed to investigate the relationships between glycans, the proteins that carry them and the proteins that bind them via the UniLectin sister project. The underlying database stores curated data on glycosylation extracted from literature and preserving the contextual information relative to species, original cell line, tissue and disease. GlyConnect is the central resource of the Glyco@Expasy collection hosted at SIB - Swiss Institute of Bioinformatics.

Mimotope database, active site-mimicking peptides selected from phage-display libraries. It is a database which stores information on peptides that have been selected from random peptide libraries based on their ability to bind small compounds, nucleic acids, proteins, cells, tissues, organs, and even entire organisms through phage display technology. Besides the peptide sequences, other information such as the corresponding target, template, library, and structures are also stored. All entries are manually extracted from published peer review articles and other public data sources such as Uniprot, GenBank and PDBSum.