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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Amy Gillespie; Amy Gillespie; Michael Conlon O'Donovan; Joe Burrage; +52 Authors

    We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant schizophrenia. Psychosis cases were characterized by significant differences in measures of blood cell proportions and elevated smoking exposure derived from the DNA methylation data, with the largest differences seen in treatment-resistant schizophrenia patients. We implemented a stringent pipeline to meta-analyze epigenome-wide association study (EWAS) results across datasets, identifying 95 DMPs associated with psychosis and 1048 DMPs associated with schizophrenia, with evidence of colocalization to regions nominated by genetic association studies of disease. Many schizophrenia-associated DNA methylation differences were only present in patients with treatment-resistant schizophrenia, potentially reflecting exposure to the atypical antipsychotic clozapine. Our results highlight how DNA methylation data can be leveraged to identify physiological (e.g., differential cell counts) and environmental (e.g., smoking) factors associated with psychosis and molecular biomarkers of treatment-resistant schizophrenia.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ CORE (RIOXX-UK Aggre...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    DOAJ-Articles
    Article . 2021
    Data sources: DOAJ-Articles
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    eLife
    Article . 2021 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    UCL Discovery
    Article . 2021
    Data sources: UCL Discovery
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    eLife
    Article . 2020
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    UNC Dataverse
    Article . 2021
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ CORE (RIOXX-UK Aggre...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      DOAJ-Articles
      Article . 2021
      Data sources: DOAJ-Articles
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      eLife
      Article . 2021 . Peer-reviewed
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      UCL Discovery
      Article . 2021
      Data sources: UCL Discovery
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      eLife
      Article . 2020
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      UNC Dataverse
      Article . 2021
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Abstract. The impact of the upper level (500 hPa) teleconnection between the North-Sea and the Caspian (NCP) on the temperature and precipitation regimes in the Eastern Mediterranean (EM) have been studied and reported and an index (NCPI) that measures the normalized geopotential heights' differences between the two poles of this teleconnection has been defined. In the present study, the impact of the NCP on the temperature regime over the entire European continent is presented. In particular, the correlation between temperature and the NCPI has been evaluated, on a monthly basis, over the entire Euro-Mediterranean domain for the 1948–2007 period. The results highlight a significant positive correlation in the north-western area of the domain and a significant negative correlation in the south-eastern one. These two poles were also highlighted by comparing the temperature anomalies associated with both phases of NCP. The importance of this sort of NCP-induced temperature bi-pole in the context of temperature variability over Europe and the Mediterranean has been evaluated by applying a Principal Component Analysis to the temperature dataset. The results showed that the temperature bi-pole is associated with the second most important mode of temperature variability over the domain, but if the analysis is restricted to the months associated to NCP (+) and NCP (−), it becomes the first mode with 29.2 % of associated variance.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Natural Hazards and ...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Natural Hazards and Earth System Sciences
    Article . 2011 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    CNR ExploRA
    Article . 2011
    Data sources: CNR ExploRA
    CNR ExploRA
    Conference object . 2012
    Data sources: CNR ExploRA
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    29
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Natural Hazards and ...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Natural Hazards and Earth System Sciences
      Article . 2011 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      CNR ExploRA
      Article . 2011
      Data sources: CNR ExploRA
      CNR ExploRA
      Conference object . 2012
      Data sources: CNR ExploRA
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Climate change is expected to generate higher short-term precipitation intensities, which may have negative consequences in terms of, for example, increased risk of flooding and sewer overflow. In this study, extreme precipitation for durations between 30 min and 1 day in simulations with the RCA3 regional climate model (RCM) for Sweden are analysed. As compared with daily observations in the period 1961–2010, the simulated extremes are found to be overall realistic with respect to magnitude, spatial homogeneity and temporal variability. In the ensemble of future projections, from 1981 to 2010 the 10-year 30-min precipitation will increase by 6% until 2011–2040, 15% until 2041–2070 and 23% until 2071–2100. The increase decreases with increasing duration and at the daily scale the percentage values are approximately halved. The values are largely consistent with earlier estimates. Assessment of the impacts on the results of the spatial resolution and the specific RCM used indicated possibilities of both smaller and larger future increases.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hydrology Researcharrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Hydrology Research
    Article . Other literature type . 2013 . 2014 . Peer-reviewed
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    24
    citations24
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hydrology Researcharrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Hydrology Research
      Article . Other literature type . 2013 . 2014 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: M. Brunetti; M. Maugeri; T. Nanni; C. Simolo; +1 Authors

    ABSTRACTHigh‐resolution monthly temperature climatologies for Italy are presented. They are based on a dense and quality‐controlled observational dataset which includes 1484 stations and on three distinct approaches: multi‐linear regression with local improvements (MLRLI), an enhanced version of the model recently used for the Greater Alpine Region, regression kriging (RK), widely used in literature and, lastly, local weighted linear regression (LWLR) of temperature versus elevation, which may be considered more suitable for the complex orography characterizing the Italian territory.Dataset and methods used both to check the station records and to get the 1961–1990 normals used for the climatologies are discussed. Advantages and shortcomings of the three approaches are investigated and the results are compared.All three approaches lead to quite reasonable models of station temperature normals, with lowest errors in spring and autumn and highest errors in winter. The LWLR approach shows slightly better performances than the other two, with monthly leave‐one‐out estimated root mean square errors ranging from 0.74 °C (April and May) to 1.03 °C (December). Further evidence in its favour is the greater reliability of local approach in modelling the behaviour of the temperature‐elevation relationship in Italy's complex territory.The comparison of the different climatologies is a very effective tool to understand the robustness of each approach. Moreover, the first two methods (MLRLI and RK) turn out to be important to tune the third one (LWLR), as they help not only to understand the relationship between temperature normals and some important physiographical variables (MLRLI) but also to study the decrease of station normals covariance with distance (RK).

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
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    International Journal of Climatology
    Article
    License: CC BY NC ND
    Data sources: UnpayWall
    CNR ExploRA
    Article . 2014
    Data sources: CNR ExploRA
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    Authors: Spinoni, J.; Brunetti, M.; Maugeri, M.; Simolo, C.;

    We present a methodology for estimating solar radiation climatologies from a sparse network of global radiation and/or sunshine duration records: it allows to obtain high-resolution grids of monthly normal values for global radiation (and for the direct and diffuse components), atmospheric turbidity, and surface absorbed radiation. We discuss the application of the methodology to a preliminary version of an Italian global radiation and sunshine duration data set, which completion is still in progress and present the resulting 1961–1990 monthly radiation climatologies.

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    Copernicus Publications
    Other ORP type . 2018
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      Copernicus Publications
      Other ORP type . 2018
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Weisse, Ralf; Bisling, Peter; Gaslikova, Lidia; Geyer, Beate; +10 Authors

    The term “climate services” is commonly used to refer to the generation of climate information, their transformation according to user needs and the subsequent use of the information in decision making processes. More generally, the concept also involves contextualization of information and knowledge. In the following a series of examples from the marine sector is described covering the generation, transformation and the use of climate information in decision making processes while contextualization is not considered. Examples comprise applications from naval architecture, offshore wind and more generally renewable energies, shipping emissions, and tidal basin water exchange and eutrophication levels. Moreover effects of climate change on coastal flood damages and the need for coastal protection are considered. Based on the analysis of these examples it is concluded that reliable climate information in data sparse regions is urgently needed, that for many applications historical climate information may be as or even more important as future long-term projections, and that the specific needs of different sectors substantially depend on their planning horizons.

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    Authors: Papadimitriou, Lamprini V.; Koutroulis, Aristeidis G.; Grillakis, Manolis G.; Tsanis, Ioannis K.;

    Global climate model (GCM) outputs feature systematic biases that render them unsuitable for direct use by impact models, especially for hydrological studies. To deal with this issue, many bias correction techniques have been developed to adjust the modelled variables against observations, focusing mainly on precipitation and temperature. However, most state-of-the-art hydrological models require more forcing variables, in addition to precipitation and temperature, such as radiation, humidity, air pressure, and wind speed. The biases in these additional variables can hinder hydrological simulations, but the effect of the bias of each variable is unexplored. Here we examine the effect of GCM biases on historical runoff simulations for each forcing variable individually, using the JULES land surface model set up at the global scale. Based on the quantified effect, we assess which variables should be included in bias correction procedures. To this end, a partial correction bias assessment experiment is conducted, to test the effect of the biases of six climate variables from a set of three GCMs. The effect of the bias of each climate variable individually is quantified by comparing the changes in simulated runoff that correspond to the bias of each tested variable. A methodology for the classification of the effect of biases in four effect categories (ECs), based on the magnitude and sensitivity of runoff changes, is developed and applied. Our results show that, while globally the largest changes in modelled runoff are caused by precipitation and temperature biases, there are regions where runoff is substantially affected by and/or more sensitive to radiation and humidity. Global maps of bias ECs reveal the regions mostly affected by the bias of each variable. Based on our findings, for global-scale applications, bias correction of radiation and humidity, in addition to that of precipitation and temperature, is advised. Finer spatial-scale information is also provided, to suggest bias correction of variables beyond precipitation and temperature for regional studies.

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    Abstract. Global Climate Model (GCM) outputs feature systematic biases that render them unsuitable for direct use by impact models, especially for hydrological studies. To deal with this issue many bias correction techniques have been developed to adjust the modelled variables against observations, focusing mainly on precipitation and temperature. However most state-of-art hydrological models require more forcing variables, additionally to precipitation and temperature, such as radiation, humidity, air pressure and wind speed. The biases in these additional variables can hinder hydrological simulations, but the effect of the bias of each variable is unexplored. Here we examine the effect of GCM biases on historical runoff simulations for each forcing variable individually, using the land surface model JULES set up at the global scale. Based on the quantified effect, we assess which variables should be included in bias correction procedures. To this end, a partial correction bias assessment experiment is conducted, to test the effect of the biases of six climate variables from a set of three GCMs. The effect of the bias of each climate variable individually is quantified by comparing the changes in simulated runoff that correspond to the bias of each tested variable. A methodology for the classification of the effect of biases in four Effect Categories (ECs), based on the magnitude and sensitivity of runoff changes, is developed and applied. Our results show that, while globally the largest changes in modelled runoff are caused by precipitation and temperature biases, there are regions where runoff is substantially affected by and/or more sensitive to radiation and humidity. Global maps of bias ECs reveal the regions mostly affected by the bias of each variable. Based on our findings, for global scale applications, bias correction of radiation and humidity, in addition to that of precipitation and temperature, is advised. Finer spatial scale information is also provided, to suggest bias correction of variables beyond precipitation and temperature for regional studies.

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    Hydrology and Earth System Sciences
    Article . 2017 . Peer-reviewed
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    Hydrology and Earth System Sciences
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    https://doi.org/10.5194/hess-2...
    Article . 2017 . Peer-reviewed
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      Hydrology and Earth System Sciences
      Article . 2017 . Peer-reviewed
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      Hydrology and Earth System Sciences
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      https://doi.org/10.5194/hess-2...
      Article . 2017 . Peer-reviewed
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    We describe the process of building a climate service centred on regional climate model results from the Rossby Centre regional climate model RCA4. The climate service has as its central facility a web service provided by the Swedish Meteorological and Hydrological Institute where users can get an idea of various aspects of climate change from a suite of maps, diagrams, explaining texts and user guides. Here we present the contents of the web service and how this has been designed and developed in collaboration with users of the service in a dialogue reaching over more than a decade. We also present the ensemble of climate projections with RCA4 that provides the fundamental climate information presented at the web service. In this context, RCA4 has been used to downscale nine different coupled atmosphere-ocean general circulation models (AOGCMs) from the 5th Coupled Model Intercomparison Project (CMIP5) to 0.44° (c. 50 km) horizontal resolution over Europe. Further, we investigate how this ensemble relates to the CMIP5 ensemble. We find that the iterative approach involving the users of the climate service has been successful as the service is widely used and is an important source of information for work on climate adaptation in Sweden. The RCA4 ensemble samples a large degree of the spread in the CMIP5 ensemble implying that it can be used to illustrate uncertainties and robustness in future climate change in Sweden. The results also show that RCA4 changes results compared to the underlying AOGCMs, sometimes in a systematic way.

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    Climate Services
    Article . 2016
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    Authors: Simolo, C.; Brunetti, M.; Maugeri, M.; Nanni, T.;

    We discuss the evolution of summer temperature extremes over Western Europe during 1961–2004 in the context of current climate warming. Using a parametric approach, we investigate the role of properties and changes in probability density functions of daily temperatures in modifying the frequency of severe, isolated events. In this perspective, the recent intensification of extremely warm events over Europe turns out to be well consistent with a pure, nonuniform shift of mean values, with no room for conjectures about increasing temperature variability.

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      Copernicus Publications
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Amy Gillespie; Amy Gillespie; Michael Conlon O'Donovan; Joe Burrage; +52 Authors

    We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant schizophrenia. Psychosis cases were characterized by significant differences in measures of blood cell proportions and elevated smoking exposure derived from the DNA methylation data, with the largest differences seen in treatment-resistant schizophrenia patients. We implemented a stringent pipeline to meta-analyze epigenome-wide association study (EWAS) results across datasets, identifying 95 DMPs associated with psychosis and 1048 DMPs associated with schizophrenia, with evidence of colocalization to regions nominated by genetic association studies of disease. Many schizophrenia-associated DNA methylation differences were only present in patients with treatment-resistant schizophrenia, potentially reflecting exposure to the atypical antipsychotic clozapine. Our results highlight how DNA methylation data can be leveraged to identify physiological (e.g., differential cell counts) and environmental (e.g., smoking) factors associated with psychosis and molecular biomarkers of treatment-resistant schizophrenia.

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    Article . 2021
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    eLife
    Article . 2021 . Peer-reviewed
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    UCL Discovery
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    eLife
    Article . 2020
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    UNC Dataverse
    Article . 2021
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      eLife
      Article . 2021 . Peer-reviewed
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      UCL Discovery
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      eLife
      Article . 2020
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      Article . 2021
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    Abstract. The impact of the upper level (500 hPa) teleconnection between the North-Sea and the Caspian (NCP) on the temperature and precipitation regimes in the Eastern Mediterranean (EM) have been studied and reported and an index (NCPI) that measures the normalized geopotential heights' differences between the two poles of this teleconnection has been defined. In the present study, the impact of the NCP on the temperature regime over the entire European continent is presented. In particular, the correlation between temperature and the NCPI has been evaluated, on a monthly basis, over the entire Euro-Mediterranean domain for the 1948–2007 period. The results highlight a significant positive correlation in the north-western area of the domain and a significant negative correlation in the south-eastern one. These two poles were also highlighted by comparing the temperature anomalies associated with both phases of NCP. The importance of this sort of NCP-induced temperature bi-pole in the context of temperature variability over Europe and the Mediterranean has been evaluated by applying a Principal Component Analysis to the temperature dataset. The results showed that the temperature bi-pole is associated with the second most important mode of temperature variability over the domain, but if the analysis is restricted to the months associated to NCP (+) and NCP (−), it becomes the first mode with 29.2 % of associated variance.

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    Natural Hazards and Earth System Sciences
    Article . 2011 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
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    Article . 2011
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    Conference object . 2012
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      Natural Hazards and Earth System Sciences
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