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When the markets become more competitive, the customer satisfaction level starts to be a more important factor. One of the principal components to achieve the customer satisfaction is to minimize the amount of defective or non-standard products. Therefore, it is convenient to consider decisions about product quality when the supply chain is planned. In this work, a mixed integer linear programming mathematical (MILP) model is developed for the supply chain planning, which determines impact of different decisions over the expected number of defective products. These decisions are: supplier selection, inbound control methods selection, and production process selection. The ob-jective function is the cost minimization associated to the supply chain planning. Sociedad Argentina de Informática e Investigación Operativa (SADIO)

Abstract: Preservation of a robust circadian rhythmicity (particulsarly of the sleep/wake cycle), a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging comes along with circadian alteration, e.g. a disrupted sleep and inflammation, that leads to metabolic disorders. In turn, sleep cycle disturbances cause numerous pathophysiological changes that accelerates the aging process. In the central nervous system, sleep disruption impairs several functions, among them, the clearance of waste molecules. The decrease of plasma melatonin, a molecule of unusual phylogenetic conservation present in all known aerobic organisms, plays a particular role as far as the endocrine sequels of aging. Every day, the late afternoon/nocturnal increase of melatonin synchronizes both the central circadian pacemaker located in the hypothalamic suprachiasmatic nuclei as well as myriads of peripheral cellular circadian clocks. This is called the “chronobiotic effect” of melatonin, the methoxyindole being the prototype of the endogenous family of chronobiotic agents. In addition, melatonin exerts a significant cytoprotective action by buffering free radicals and reversing inflammation via down regulation of proinflammatory cytokines, suppression of low degree inflammation and prevention of insulin resistance. Because of these properties melatonin has been advocated to be a potential therapeutic tool in COVID 19 pandemic. Melatonin administration to aged animals counteracts a significant number of senescence-related changes. In humans, melatonin is effective both as a chronobiotic and a cytoprotective agent to maintain a healthy aging. Circulating melatonin levels are consistently reduced in the metabolic syndrome, ischemic and non-ischemic cardiovascular diseases and neurodegenerative disorders like the Alzheimer's and Parkinson's diseases. The potential therapeutic value of melatonin has been suggested by a limited number of clinical trials generally employing melatonin in the 2–10 mg/day range. However, from animal studies the cytoprotective effects of melatonin need higher doses to become apparent (i.e. in the 100 mg/day range). Hence, controlled studies employing melatonin doses in this range are urgently needed.

La Plata as Smart City: Ideas - Planning. - Define priorities for citizen services. - Web & Mobile citizen services. - Health and Security applications. - Emergency applications. - Traffic applications. Facultad de Informática

Abstract: Mechanisms mediating vascular calcification recapitulate osteogenic processes encompassing bone formation and imply participation of bone related proteins such as bone morphogenetic protein-2 (BMP-2). Macrophages are amongst the cells that contribute to vascular ossification by releasing cytokines that induce an osteogenic program in vascular smooth muscle cells, and also by becoming themselves osteoclast-like cells. In inflammatory vascular disease, the macrophage population in the vascular wall is diverse, with the M1 or inflammatory, and the M2 or anti-inflammatory macrophage types being dominant. Yet, the osteogenic potential of M1 and M2 macrophages remains unknown. Prompted by recent studies from our laboratory showing that in macrophages the Transient Receptor Potential Canonical 3 (TRPC3) channel contributes to endoplasmic reticulum (ER) stress-induced apoptosis in M1, but not in M2 macrophages, and given the strong relationship between ER stress and vascular calcification, we wished to examine whether TRPC3 would play a role in the osteogenic signaling of polarized macrophages. The findings reported here indicate that a constitutive BMP-2-dependent signaling operates in M1 macrophages, which is not affected by deletion of Trpc3 and is not subject to regulation by ER stress. Our studies suggest operation of an auto/paracrine mechanism by which BMP-2 secreted by M1 macrophages maintains constitutive activation of a BMP-2 receptor/SMAD1/5 signaling axis.

The senses have attracted much attention in cultural studies in recent times. Which senses are important in different cultures? What is the relationship between sensory experience and reasoning? Which senses are considered reliable sources of knowledge? Which senses are linked to emotions like love or disgust? With which senses are gods or angels perceived? Which experiences of the senses have a part to play in festivals and religious celebrations? How do theory and practice of the senses relate to each other? In the last few years, questions about the senses have also started to attract the interest of scholars in the fields of Hebrew Bible and ancient Near Eastern studies, which is the focus of this volume. For example, since 2009 there has been a program unit on Senses, Cultures, and the Biblical World at the Annual Meeting of the Society of Biblical Literature; in 2012 Yael Avrahami published a monograph on The Senses of Scripture: Sensory Perception in the Hebrew Bible (New York: T&T Clark); 2015 marked the beginning of the interdisciplinary synaesthesia project at the University of Toulouse; since 2016 there have been sessions on Senses and Sensibility in the Near East at the Annual Meeting of the American Schools of Oriental Research; and in 2017 Nicole L. Tilford authored the book Sensing World, Sensing Wisdom: The Cognitive Foundation of Biblical Metaphors (Atlanta: SBL Press). So far, the respective discussions are still very fresh, and most of them take place outside Europe. This prompted us to organize an international and interdisciplinary conference on the topic, inviting many of the pioneers behind the development mentioned above. The conference took place at the University of Vienna on March 23–25, 2017. Its title, and thus the title of this volume, was inspired by an article by David Howes and Constance Classen, “Conclusion: Sounding Sensory Profiles” (pages 257–88 in The Varieties of Sensory Experience: A Sourcebook in the Anthropology of the Senses, ed. David Howes [Toronto: University of Toronto Press, 1991]), which is reprinted in this volume. The present volume brings together most of the contributions to this meeting, supplemented by a few other articles on the subject. It offers insights into the meaning of the senses in ancient Israel, Mesopotamia, and Egypt and shows various questions and methods with which this topic can be approached. We hope that this will provide a stimulus and a basis for further exploration of the senses in the ancient Near East. We would like to thank the Universities of Vienna and Zurich for funding the conference and the publication of this volume. Our thanks go to everyone who contributed a paper to the conference and to this volume, to Alan Lenzi, Jeffrey Stackert, and the editorial board of the Ancient Near East Monographs for the inclusion of this volume in this series, and to Nicole Tilford and the SBL Press staff for their excellent editorial work. Special thanks are due to Jeanine Lefèvre, Nina Beerli, Christian Sichera, and Sarah Herzog for their help in the preparation of the manuscript.

As someone famously said, irony is usually regarded as “saying what you mean without meaning what you say. ”But how exactly this can be achieved is not easy to answer. More precisely, this characterization applies to verbal irony. Verbal irony has classically been conceived of as the act of saying something and meaning the opposite. But some forms of irony usually recognized are not verbal; they include situational irony and dramatic irony; situational irony is not intentional, in the sense that something happens that is the opposite of what might be expectedand the result has a negative character (irony of fate). Dramatic irony, according to the Oxford Dictionary, is “[a] literary technique, originally used in Greek tragedy, by which the full significance of a character’s words or actions is clear to the audience or reader although unknown to the character.” Well-known examples include Shakespeare’s tragedies and Oedipus’ story (the audience knows, while Oedipus does not, that he himself is the murderer he is seeking). Other forms of irony that are often mentioned are Socratic irony and Romantic irony. Instituto de Investigaciones en Humanidades y Ciencias Sociales

This article described the process used for developing and validating an analysis framework that allows comparing design methodologies for the design creation of Learning Objects (LO) and selecting the one that best meets the needs of teachers based on the needs of a specific educational context. This framework is called MASMDOA (Analysis Framework for the Selection of a Learning Object Design and Deployment Methodology), and it has been applied to a case study where, from a compilation of LO design methodologies used in Ibero-America, one of these methodologies is selected to work in the context of a LO design and production workshop. MASMDOA proved useful for selecting a LO design and deployment methodology that is appropriate for the requirements of an educator in a specific context. To achieve this, MASMDOA proposes a set of criteria that are useful for recommending and characterizing the methodologies to be analyzed and, following a two-phase process, it recommends the methodology that is better suited for the educator's needs. In this paper, we present MASMDOA, the case study to which it was applied, and the results obtained. Instituto de Investigación en Informática

Abstract: Two highly relevant studies related to SARS-CoV-2 and coronavirus disease (COVID-19) and supporting the use of melatonin to prevent and treat this serious infection were published recently. Campos-Codo and colleagues [1] documented experimentally their claim that drugs which specifically target hypoxia inducible factor-1α (HIF-1α) would likely have great therapeutic value in treating COVID-19. The second report is a retrospective analysis based on the clinical experience at the Columbia University Irving Medical Center with the use of drugs to treat respiratory distress in COVID-19-infected patients who required endotracheal intubation [2]. Hyperinflammatory monocytes/macrophages accumulate in abundance in the lower respiratory tract where they play a key role in determining the severity of SARS-CoV-2 infections. Campos-Codo, et al. [1] found that monocytes/macrophages infected with the SARSCoV-2 virus reprogram their metabolism from the conventional mitochondrial oxidative phosphorylation (OXPHOS) to the (usually) pathological cytosolic glycolysis. This so-called Warburg-type metabolism is aided by the inadequately controlled elevated blood glucose levels of diabetic patients, which enhances cellular glycolysis, viral replication and hastens development of a severe respiratory infection resulting from the elevated cytokine release (“cytokine storm”).

This work presents an analysis on the behavior of a particular metaheuristic technique inspired by Simulated Annealing, SA, for the resolution of a problem of sensor network design in process plants, SNDP. This design problem is formulated as a combinatorial optimization problem and includes the selection and determination of the number of process variables that must be measured to achieve the specific state of knowledge about the plant. Different parametric configurations for the proposed heuristic are analyzed and discussed, as well as their performance in plants of increasing size and complexity. Red de Universidades con Carreras en Informática XX Workshop Agentes y Sistemas Inteligentes.

We introduce a model for the spatial distribution of cell phone antennas in the city of Buenos Aires (CABA). After showing that the complete spatial randomness (homogeneous Poisson distribution) hy- pothesis does not hold, we propose a model in which each point is dis- tributed according to a bivariate Gaussian variable with mean given by the barycenter of its neighbors in the Delaunay triangulation. We show that this model is suitable, and can be used to generate a synthetic dis- tribution of antennas. The generated distribution contains no sensitive or proprietary information, and can thus be freely shared with research groups, fostering further research on the subject. Sociedad Argentina de Informática e Investigación Operativa (SADIO)