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Cette contribution s’intéresse à l’impact de la pandémie de COVID-19 sur les Établissements et Services d’Aide par le Travail (ESAT) français à partir d’entretiens conduits auprès de directeurs d’établissements situés dans le milieu rural et urbain de la Région Auvergne-Rhône-Alpes (France). Afin de situer les ESAT dans leur contexte national, un premier temps est consacré à rappeler la genèse et le fonctionnement de ce dispositif, mis en place pour favoriser l’insertion sociale et professionnelle des travailleurs en situation de handicap, dont l’originalité réside dans l’articulation d’une logique médico-sociale à une logique économique. Nous cherchons ensuite à montrer comment les ESAT se sont organisés pour assurer l’accompagnement médico-social de leurs travailleurs malgré l’obligation de distanciation. Puis, analysé au prisme de l’ancrage territorial et de la notion de proximité qui lui est associée, nous nous intéressons à l’impact du confinement sur l’équilibre économique de ces établissements pour montrer que la crise sanitaire a moins affecté les établissements à vocation majoritairement agricole implantés en milieu rural que ceux, plus orientés vers la sous-traitance industrielle, localisés en milieu urbain. This contribution focuses on the impact of the COVID-19 pandemic on French support and work assistance establishment (ESAT) based on interviews conducted with managers of institutions located in rural and urban areas of the Auvergne-Rhône-Alpes region (France). In order to situate the ESAT in their national context, a first section is devoted to recalling the genesis and functioning of this system, which was set up to promote the social and occupational integration of workers with disabilities, whose originality lies in the articulation of a medico-social logic with an economical logic. We then try to show how the ESAT have organized themselves to provide medico-social support for workers with disabilities despite the obligation of distancing. Then, analyzed through the prism of territorial anchoring and the concept of proximity associated with it, we will focus on the impact of confinement on the economic balance of these establishments to show that the health crisis has less affected the establishments in predominantly agricultural vocation established in rural areas than those, more oriented towards industrial subcontracting, located in urban areas.

What are the psychological consequences of the increasingly politicized nature of the COVID-19 pandemic in the United States relative to similar Western countries? In a two-wave study completed early (March) and later (December) in the pandemic, we found that polarization was greater in the United States ( N = 1,339) than in Canada ( N = 644) and the United Kingdom. ( N = 1,283). Political conservatism in the United States was strongly associated with engaging in weaker mitigation behaviors, lower COVID-19 risk perceptions, greater misperceptions, and stronger vaccination hesitancy. Although there was some evidence that cognitive sophistication was associated with increased polarization in the United States in December (but not March), cognitive sophistication was nonetheless consistently negatively correlated with misperceptions and vaccination hesitancy across time, countries, and party lines. Furthermore, COVID-19 skepticism in the United States was strongly correlated with distrust in liberal-leaning mainstream news outlets and trust in conservative-leaning news outlets, suggesting that polarization may be driven by differences in information environments.

Daté 2020 mais paru en 2021; International audience; Cet article vise à revenir sur l'activité de Jean Rottner pendant la crise du coronavirus à partir d'une analyse détaillée de ses interventions durant cette période, qui font de lui un acteur bénéficiant d'une médiatisation importante sinon extraordinaire. Pour ce faire, l'article mobilise la notion de conjoncture critique. Il défend la thèse que c'est le gestionnaire hospitalier plus que le soignant qui agit de manière ajustée dans la crise, mais aussi l'élu local qui tente de consolider sa position. L'analyse se fonde sur un dépouillement de la presse nationale et régionale ainsi que sur d'autres sources complémentaires.

International audience

The ongoing COVID-19 outbreak has expanded rapidly throughout China. Major behavioral, clinical, and state interventions are underway currently to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. It remains unclear how these unprecedented interventions, including travel restrictions, have affected COVID-19 spread in China. We use real-time mobility data from Wuhan and detailed case data including travel history to elucidate the role of case importation on transmission in cities across China and ascertain the impact of control measures. Early on, the spatial distribution of COVID-19 cases in China was well explained by human mobility data. Following the implementation of control measures, this correlation dropped and growth rates became negative in most locations, although shifts in the demographics of reported cases are still indicative of local chains of transmission outside Wuhan. This study shows that the drastic control measures implemented in China have substantially mitigated the spread of COVID-19. One sentence summary: The spread of COVID-19 in China was driven by human mobility early on and mitigated substantially by drastic control measures implemented since the end of January.

National audience; Cet article analyse les programmes santé des candidats aux élections présidentielles de 2022. Alors que les questions de politique sanitaire auraient dû prendre une place centrale avec la pandémie de Covid-19, leur traitement demeure mitigé. Déserts médicaux, brevets pharmaceutiques, accroissement des moyens de l’hôpital public, réforme des professions de santé… de nombreux sujets ont été soulevés durant cette campagne. Mais les candidats se sont heurtés à un double écueil : l’entrée tardive d’Emmanuel Macron en campagne et sa mise à distance de tout débat de premier tour. Résultat : ses concurrents peinent à se comparer au bilan comme au projet du président sortant en la matière. D’autant plus que l’agenda électoral a été balayé par l’irruption du conflit russo-ukrainien.

The binding of F4+ enterotoxigenic Escherichia coli (ETEC) and the specific receptor on porcine intestinal epithelial cells is the initial step in F4+ ETEC infection. Porcine aminopeptidase N (APN) is a newly discovered receptor for F4 fimbriae that binds directly to FaeG adhesin, which is the major subunit of the F4 fimbriae variants F4ab, F4ac, and F4ad. We used overlapping peptide assays to map the APN-FaeG binding sites, which has facilitated in the identifying the APN-binding amino acids that are located in the same region of FaeG variants, thereby limiting the major binding regions of APN to 13 peptides. To determine the core sequence motif, a panel of FaeG peptides with point mutations and FaeG mutants were constructed. Pull-down and binding reactivity assays using piglet intestines determined that the amino acids G159 of F4ab, N209 and L212 of F4ac, and A200 of F4ad were the critical residues for APN binding of FaeG. We further show using ELISA and confocal microscopy assay that amino acids 553–568, and 652–670 of the APN comprise the linear epitope for FaeG binding in all three F4 fimbriae variants. Electronic supplementary material The online version of this article (10.1186/s13567-018-0519-9) contains supplementary material, which is available to authorized users.

For the last two decades, researchers have placed hopes in a new era in which a combination of reperfusion and neuroprotection would revolutionize the treatment of stroke. Nevertheless, despite the thousands of papers available in the literature showing positive results in preclinical stroke models, randomized clinical trials have failed to show efficacy. It seems clear now that the existing data obtained in preclinical research have depicted an incomplete picture of stroke pathophysiology. In order to ameliorate bench-to-bed translation, in this review we first describe the main actors on stroke inflammatory and immune responses based on the available preclinical data, highlighting the fact that the link between leukocyte infiltration, lesion volume and neurological outcome remains unclear. We then describe what is known on neuroinflammation and immune responses in stroke patients, and summarize the results of the clinical trials on immunomodulatory drugs. In order to understand the gap between clinical trials and preclinical results on stroke, we discuss in detail the experimental results that served as the basis for the summarized clinical trials on immunomodulatory drugs, focusing on (i) experimental stroke models, (ii) the timing and selection of outcome measuring, (iii) alternative entry routes for leukocytes into the ischemic region, and (iv) factors affecting stroke outcome such as gender differences, ageing, comorbidities like hypertension and diabetes, obesity, tobacco, alcohol consumption and previous infections like Covid-19. We can do better for stroke treatment, especially when targeting inflammation following stroke. We need to re-think the design of stroke experimental setups, notably by (i) using clinically relevant models of stroke, (ii) including both radiological and neurological outcomes, (iii) performing long-term follow-up studies, (iv) conducting large-scale preclinical stroke trials, and (v) including stroke comorbidities in preclinical research. Highlights • The different experimental approaches may model different aspects of stroke. • Drugs need to be tested in several clinically relevant experimental stroke models. • Clot composition, type of arterial occlusion and recanalization need to be considered. • Outcomes should include acute but also long-term measurements. • Both infarct volume and behavioral deficits need to be systematically measured. • Including coexisting risk factors in preclinical stroke research is mandatory. • Performing multicenter studies may increase the reliability of preclinical results.

Avec la crise du coronavirus, les destinations lointaines de nature comme la Patagonie chilienne sont inquiètes d’un effondrement du tourisme. Les communautés locales, apeurées par les risques liés à l’accueil de visiteurs, se replient et se protègent. Les entrepreneurs espèrent un rapide retour à la « normalité » d’une zone relativement épargnée par la COVID-19, mais craignent la fin du boom touristique, car prendre l’avion restera anxiogène dans un contexte de pandémie. Ces destinations devraient recentrer leur offre afin de capter une clientèle de proximité, mais cela semble un défi peu rentable pour les zones isolées. Alors que les entrepreneurs affinent leur plan marketing et les services d’État leurs protocoles d’accueil sécurisés, les animateurs de projets touristiques écologiques, axés sur la conservation, le tourisme rural et les migrations d’agrément, font valoir leurs atouts. L’actuelle crise pourrait mettre fin au tourisme de masse, à l’hypermobilité vers des hauts lieux et aux projets basés sur la rentabilité. La crise socioenvironnementale globale est l’occasion de repenser les rapports à la nature et de renforcer les systèmes touristiques locaux, pensés comme des lieux de vie, basés sur des économies rurales respectueuses de l’environnement, les échanges culturels, scientifiques et traditionnels, attirants autant pour les clientèles nationales qu’étrangères. With the coronavirus crisis, remote nature destinations like Chilean Patagonia are worried of a possible collapse of tourism. Local communities, frightened by the risks of welcoming visitors, are withdrawing and protecting themselves. Entrepreneurs hope for a rapid return to “normality” in an area relatively untouched by COVID-19 but they fear the end of the tourism boom, as flying will remain an anxiety-provoking issue in a post-pandemic situation. These destinations have to refocus their offer in order to capture a national clientele, but this seems an unprofitable challenge for isolated areas. While entrepreneurs are refining their marketing plans and government services are establishing their secure reception protocols, leaders of ecological and conservation tourism projects along with rural tourism and leisure migration stakeholders are highlighting their assets. The current crisis could put an end to mass tourism, hypermobilities, projects based on high profitability and overtourism in iconic places. In that sense, the present global socioenvironmental crisis is an opportunity to rethink our relationship with nature and seek ways to strengthen local tourism systems, conceived as places to live and based on environmentally friendly rural economies, cultural, scientific, and traditional exchanges, attractive both to national and foreign visitors.

Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. Electronic supplementary material The online version of this article (doi:10.1186/s12879-014-0635-8) contains supplementary material, which is available to authorized users.