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  • Open Access English
    Authors: 
    Rasmussen, Kim Krighaar; Frandsen, Kristian E. H.; Boeri Erba, Elisabetta; Pedersen, Margit; Varming, Anders K.; Hammer, Karin; Kilstrup, Mogens; Thulstrup, Peter W.; Blackledge, Martin; Jensen, Malene Ringkjøbing; +1 more
    Publisher: HAL CCSD
    Countries: France, Denmark, Denmark, Germany, France
    Project: EC | BIOSTRUCT-X (283570)

    Scientific reports 6, 29574 (2016). doi:10.1038/srep29574

  • Open Access English
    Authors: 
    K. Verschueren; C. Blanchet; Jan Felix; Ann Dansercoer; Dirk De Vos; Yehudi Bloch; J. Van Beeumen; Dmitri I. Svergun; Irina Gutsche; Savvas N. Savvides; +1 more
    Publisher: HAL CCSD
    Countries: Belgium, France
    Project: EC | CALIPSOplus (730872), EC | Chap4Resp (647784), EC | iNEXT (653706)

    Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA...

  • Open Access English
    Authors: 
    Simoben, Conrad; Robaa, Dina; Chakrabarti, Alokta; Schmidtkunz, Karin; Marek, Martin; Lancelot, Julien; Kannan, Srinivasaraghavan; Melesina, Jelena; Shaik, Tajith; Pierce, Raymond; +3 more
    Publisher: Multidisciplinary Digital Publishing Institute
    Country: France
    Project: EC | A-PARADDISE (602080), EC | SETTREND (241865)

    International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the cr...

  • Open Access English
    Authors: 
    Maryam Alqabandi; Nicola De Franceschi; Sourav Maity; Nolwenn Miguet; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Publisher: Cold Spring Harbor Laboratory
    Countries: Sweden, France, Netherlands
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | ESCRT model (751715), EC | INTERACT (751404), ANR | ESCRTfission (ANR-14-CE09-0003), ANR | PSL (ANR-10-IDEX-0001)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

  • English
    Authors: 
    Ribeiro, João P.; Hassan, Mohamed Ali Abol; Rouf, Razina; Tiralongo, Evelin; May, Tom W.; Day, Christopher J.; Imberty, Anne; Tiralongo, Joe; Varrot, Annabelle;
    Publisher: HAL CCSD
    Country: France
    Project: EC | BIOSTRUCT-X (283570)

    International audience; A lectin with strong cytotoxic effect on human colon cancer HT29 and monkey kidney VERO cells was recently identified from the Australian indigenous mushroom Psathyrella asperospora and named PAL. We herein present its biochemical and structural ...

  • Open Access English
    Authors: 
    Duval, Mélodie; Korepanov, Alexey; Fuchsbauer, Olivier; Fechter, Pierre; Haller, Andrea; Fabbretti, Attilio; Choulier, Laurence; Micura, Ronald; Klaholz, Bruno P.; Romby, Pascale; +2 more
    Publisher: HAL CCSD
    Country: France
    Project: EC | TRANSLATIONMACHINERY (243296), ANR | STIR (ANR-07-BLAN-0351), FWF | Synthesis of RNA-peptide ... (P 21641)

    Author Summary Gene expression is regulated at multiple levels, including the decision of whether or not to translate a mRNA. This phenomenon, known as translational regulation, allows rapid changes in cellular concentrations of proteins and is well suited to the adjust...

  • Open Access English
    Authors: 
    Macek, Pavel; Kerfah, Rime; Erba, Elisabetta Boeri; Crublet, Elodie; Moriscot, Christine; Schoehn, Guy; Amero, Carlos; Boisbouvier, Jerome;
    Publisher: HAL CCSD
    Country: France
    Project: EC | SEENANOLIFEINACTION (260887)

    The spontaneous formation of biological higher-order structures from smaller building blocks, called self-assembly, is a fundamental attribute of life. Although the protein self-assembly is a time-dependent process that occurs at the molecular level, its current underst...

  • Open Access English
    Authors: 
    Gerlach, Piotr; Malet, Hélène; Cusack, Stephen; Reguera, Juan;
    Publisher: Cell Press
    Country: France
    Project: EC | V-RNA (322586)

    Summary Segmented negative-strand RNA virus (sNSV) polymerases transcribe and replicate the viral RNA (vRNA) within a ribonucleoprotein particle (RNP). We present cryo-EM and X-ray structures of, respectively, apo- and vRNA bound La Crosse orthobunyavirus (LACV) polymer...

  • Publication . Article . Other literature type . 2016
    Open Access English
    Authors: 
    Mansouri, Maysam; Bellon-Echeverria, Itxaso; Rizk, Aurélien; Ehsaei, Zahra; Cianciolo Cosentino, Chiara; Silva, Catarina S; Xie, Ye; Boyce, Frederick M; Davis, M Wayne; Neuhauss, Stephan C F; +4 more
    Publisher: HAL CCSD
    Countries: Switzerland, United Kingdom, France, France
    Project: EC | BIOSTRUCT-X (283570), SNSF | Structure/function analys... (31003A_130463), EC | SYNSIGNAL (613879), SNSF | Decision making in the en... (31003A-118351), EC | COMPLEXINC (279039), SNSF | Structural and functional... (31003A_152908)

    Multigene delivery and subsequent cellular expression is emerging as a key technology required in diverse research fields including, synthetic and structural biology, cellular reprogramming and functional pharmaceutical screening. Current viral delivery systems such as ...

  • Open Access English
    Authors: 
    Sharma, Urvashi; Carrique, Loïc; Vadon-Le Goff, Sandrine; Mariano, Natacha; Georges, Rainier-Numa; Delolme, Frederic; Koivunen, Peppi; Myllyharju, Johanna; Moali, Catherine; Aghajari, Nushin; +1 more
    Publisher: Nature Portfolio
    Countries: United Kingdom, France, Finland
    Project: EC | BIOSTRUCT-X (283570)

    Fibrillar collagen molecules are synthesized as precursors, procollagens, with large propeptide extensions. While a homotrimeric form (three α1 chains) has been reported in embryonic tissues as well as in diseases (cancer, fibrosis, genetic disorders), collagen type I u...