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description Publicationkeyboard_double_arrow_right Other literature type 2008 Greece Greek, Modern (1453-)Εταιρεία Μελέτης Νέου Ελληνισμού (ΕΜΝΕ) Journal URL: http://www.mnimon.gr/ Το εικονογραφημένο μονόφυλλο με χρησμολογικό περιεχόμενο που παρουσιάζεται σχολιασμένο βρίσκεται στη Μαρκιανή Βιβλιοθήκη της Βενετίας, σε σύμμεικτο τόμο, που σταχώθηκε στο δεύτερο μισό του 19ου αι. και φέρει στη ράχη του επιγραφή Parte Veneto Guerre col Turco 1668 al 1717.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2008 Greece Greek, Modern (1453-)Εταιρεία Μελέτης Νέου Ελληνισμού (ΕΜΝΕ) Journal URL: http://www.mnimon.gr/
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2000 Greece EnglishGorgoulis, V. G.; Zacharatos, P.; Kotsinas, A.; Mariatos, G.; Liloglou, T.; Vogiatzi, T.; Foukas, P.; Rassidakis, G.; Garinis, G.; Ioannides, T.; Zoumpourlis, V.; Bramis, J.; Michail, P. O.; Asimacopoulos, P. J.; John Field; Kittas, C.;pmc: PMC1949940
pmid: 10965496
Background: Recent in vitro studies provide evidence that the cell cycle molecules pRb, p53 and MDM2 form a tightly regulated protein network. In this study, we examined the relationship of this protein network in a series of non-small cell lung carcinomas (NSCLCs), with the kinetic parameters, including proliferative activity or proliferation index (PI) and apoptotic index (AI), and ploidy status of the tumors. Material and Methods: A total of 87 NSCLCs were examined using immunohistochemical and molecular methods in order to estimate the status of the pRb-p53-MDM2 network. The kinetic parameters and the ploidy status of the tumors were assessed by in situ assays. The possible associations between alterations of the network, kinetic parameters and ploidy status of the carcinomas were assessed with a series of statistical methods. Results: Aberrant expression of pRb (Ab) and overexpression of p53 (P) and MDM2 (P) proteins were observed in 39%, 57%, and 68% of the carcinomas, respectively. The comprehensive analysis revealed that concurrent alterations in all three cell cycle regulatory molecules were the most frequent pattern, pRb(Ab)/p53(P)/MDM2(P); this “full abnormal” phenotype represented approximately 27% of the cases. This immunoprofile obtained the highest PI/AI value; whereas, the “normal” phenotype was the lowest one (p = 0.004). Furthermore, the pattern pRb(Ab)/p53(P)/MDM2(P) acquired the highest PI (p < 0.001) and lowest AI (p < 0.001) scores. Interestingly, the groups of carcinomas with impaired expression of one or two molecules attained PI/AI ratio values clustered in a narrow range placed in the middle of the scores exhibited by the “normal” and “full abnormal” phenotypes. These tumors had significantly lower AI, but similar PI values, compared with those noticed in the normal pattern. In addition, it was observed that the pRb(Ab)/p53(P)/MDM2(P) phenotype was also significantly associated with aneuploidy (p = 0.002) and a tendency was observed when the expression of two components was altered (p = 0.055). Conclusions: Our findings suggest that simultaneous deregulation of all members of the pRb-p53-MDM2 network confers an additive effect on tumor growth. The apoptotic pathway seems to be more susceptible to its defects than the cell proliferation machinery. The findings of the ploidy analysis, which are in parallel with those regarding the proliferative activity and the apoptotic rate study, further support the concept that these molecules constitute a tightly regulated network participating in cell cycle control and chromosomal stability.
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For further information contact us at helpdesk@openaire.eu36 citations 36 popularity Average influence Top 10% impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece Greek, Modern (1453-)Εθνικό Ιδρυμα Ερευνών (ΕΙΕ), Αθήνα, 2006 H παρούσα μελέτη αποσκοπεί να παρουσιάσει συνοπτικά τις διάφορες θεωρίες σχετικά με την προέλευση της ζωής και να εξηγήσει διάφορες πειραματικές μαρτυρίες που είναι σήμερα δημοσιευμένες. Γίνεται μια επιστημονική ξενάγηση από τον χρόνο μηδέν έως σήμερα και συζητούνται διάφορα ερωτήματα σχετικά με το πώς περίπου νομίζουμε ότι έχει προέλθει η ζωή στον πλανήτη μας. Η ζωή είναι συνυφασμένη με όλες τις ζωντανές υπάρξεις, με ή χωρίς συνείδηση, δημιουργήματα με πολύ ωραία χρώματα και εξαιρετική ποικιλία. Το ζωικό Βασίλειο αποτελείται από περισσότερα από δέκα εκατομμύρια είδη με εκπληκτική ποικιλομορφία. Στον πλανήτη μας μόνο, οι μικροοργανισμοί είναι περισσότεροι από ένα εκατομμύριο.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece EnglishEuropean Centre for Byzantine and Post-Byzantine monuments, 2006 Authors: Drakopoulou, Eugenia;Drakopoulou, Eugenia;207 p. : coloured icons, maps
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece EnglishWiley-Blackwell Publishing Ltd. Authors: Theodorou, Marina C.; Theodorou, E.C.; Panagiotidis, C.A.; Kyriakidis, D.A.;Theodorou, Marina C.; Theodorou, E.C.; Panagiotidis, C.A.; Kyriakidis, D.A.;Abstract Poster Presentation The AtoS-AtoC/Az two-component system activates the ato- DAEB operon expression upon acetoacetate induction for E. coli growth in short-chain fatty acids. It also enhances the poly (3- OH-butyrate) (cPHB) biosynthesis, upon acetoacetate induction as well as in the presence of spermidine. The response regulator of the system is the antizyme (Az) of ornithine decarboxylase and is the product of atoC gene. It belongs to the NtrC-NifA family of sigma54-RNA polymerase transcriptional activators. AtoC contains two putative phosphorylation sites, i.e. a conserved aspartic acid among the response regulators and a histidine residue in an H box consensus sequence, normally common to histidine kinases. We report here, that only phosphorylationcompetent AtoC can lead to enhanced production of cPHB in E. coli, when overexpressed with AtoS. Specifically, upon acetoacetate induction, the mutation of Asp reduces cPHB accumulation, compared with cells expressing wild-type AtoC. The mutation of His residue has an even more pronounced effect. The relative effects of these mutations on cPHB accumulation are consistent with their effects on atoDAEB operon expression, i.e. the mutation of Asp has a more potent phenotype than the substitution of His, in the presence of spermidine. Introduction of both AtoC mutations render the system unresponsive to acetoacetate as well as polyamine, resulting in total abrogation of the AtoS-AtoC/Az overexpression effect phenotype to cPHB levels in E. coli.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece EnglishΑρχαιογνωσία, Αθήνα, 2006 All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1457::577c7253c8cec93753c45c5bd74f9412&type=result"></script>'); --> </script>
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2007 Greece, FranceSpringer Science and Business Media LLC Authors: Jalal Errami; Michel Peyrard; Nikos Theodorakopoulos;Jalal Errami; Michel Peyrard; Nikos Theodorakopoulos;pmid: 17728978
We report model calculations on DNA single strands which describe the equilibrium dynamics and kinetics of hairpin formation and melting. Modeling is at the level of single bases. Strand rigidity is described in terms of simple polymer models; alternative calculations performed using the freely rotating chain and the discrete Kratky-Porod models are reported. Stem formation is modeled according to the Peyrard-Bishop-Dauxois Hamiltonian. The kinetics of opening and closing is described in terms of a diffusion-controlled motion in an effective free energy landscape. Melting profiles, dependence of melting temperature on loop length, and kinetic time scales are in semiquantitative agreement with experimental data obtained from fluorescent DNA beacons forming poly(T) loops. Variation in strand rigidity is not sufficient to account for the large activation enthalpy of closing and the strong loop length dependence observed in hairpins forming poly(A) loops. Implications for modeling single strands of DNA or RNA are discussed. Comment: 15 pages, 17 figures, submitted to Eur. J. Phys. E
HELIOS Repository arrow_drop_down The European Physical Journal EArticle . 2007License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Average influence Average impulse Average Powered by BIP!
more_vert HELIOS Repository arrow_drop_down The European Physical Journal EArticle . 2007License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2011 Greece Greek, Modern (1453-)Φιλίστωρ Authors: Kallivretakis, Leonidas;Kallivretakis, Leonidas;152 σ. : εικ. ; 23 εκ. + 1 (διπλ.) χάρτης (50,5 x 49 εκ.) Στο βιβλίο αυτό περιγράφονται και τεκμηριώνονται ιστορικά οι διαδρομές του παλαίμαχου Κρητικού ταξίαρχου Δημήτριου Μαρκόπουλου και του καπετάνιου της Ρούμελης Διαμαντή, που διασταυρώθηκαν μέσα στη θύελλα των τελευταίων μηνών του Ελληνικού Εμφυλίου Πολέμου, σε μια πορεία που στο τέρμα της περίμενε και τους δύο ο θάνατος. Η δραματική μοίρα δύο γενναίων πολεμιστών της πρώτης γραμμής, παγιδευμένων μέσα σ' έναν αόρατο ιστό δολοπλοκιών που εμπλέκουν την ανώτατη πολιτική και στρατιωτική ηγεσία των δύο αντιπάλων πλευρών. Στρατηγικά και τακτικά σφάλματα, αυθαίρετες αποφάσεις ζωής και θανάτου μέσα στην έπαρση του επικειμένου θριάμβου ή στην απελπισία της επερχόμενης κατάρρευσης, σύνδεσμοι που χάνονται, επιστολές που φθάνουν καθυστερημένα στον προορισμό τους, γιάφκες στο κέντρο της Αθήνας και αντάρτικες λούφες στα δασωμένα βουνά, στόματα που παραμένουν σφραγισμένα μισόν αιώνα μετά, συστηματικές εκστρατείες παραπληροφόρησης, προδοσίες από εχθρούς και φίλους, υφαίνουν το συναρπαστικό μίτο μιας (αληθινής ωστόσο) ιστορίας μυστηρίου.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2011 Greece Greek, Modern (1453-)Δημοσιογραφικός Οργανισμός Λαμπράκη Α.Ε. Στο πλαίσιο της παρουσίασης μέρους των πορισμάτων της ιστορικής έρευνας που διεξάγεται στο Εθνικό Ίδρυμα Ερευνών για την εξέγερση του Πολυτεχνείου, τεκμηριώνεται εδώ αναλυτικά η εκτέλεση του 20χρονου Μιχάλη Μυρογιάννη από τον αντισυνταγματάρχη Νικόλαο Ντερτιλή στις 18 Νοεμβρίου 1973
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description Publicationkeyboard_double_arrow_right Other literature type 2008 Greece Greek, Modern (1453-)Εταιρεία Μελέτης Νέου Ελληνισμού (ΕΜΝΕ) Journal URL: http://www.mnimon.gr/ Το εικονογραφημένο μονόφυλλο με χρησμολογικό περιεχόμενο που παρουσιάζεται σχολιασμένο βρίσκεται στη Μαρκιανή Βιβλιοθήκη της Βενετίας, σε σύμμεικτο τόμο, που σταχώθηκε στο δεύτερο μισό του 19ου αι. και φέρει στη ράχη του επιγραφή Parte Veneto Guerre col Turco 1668 al 1717.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2008 Greece Greek, Modern (1453-)Εταιρεία Μελέτης Νέου Ελληνισμού (ΕΜΝΕ) Journal URL: http://www.mnimon.gr/
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2000 Greece EnglishGorgoulis, V. G.; Zacharatos, P.; Kotsinas, A.; Mariatos, G.; Liloglou, T.; Vogiatzi, T.; Foukas, P.; Rassidakis, G.; Garinis, G.; Ioannides, T.; Zoumpourlis, V.; Bramis, J.; Michail, P. O.; Asimacopoulos, P. J.; John Field; Kittas, C.;pmc: PMC1949940
pmid: 10965496
Background: Recent in vitro studies provide evidence that the cell cycle molecules pRb, p53 and MDM2 form a tightly regulated protein network. In this study, we examined the relationship of this protein network in a series of non-small cell lung carcinomas (NSCLCs), with the kinetic parameters, including proliferative activity or proliferation index (PI) and apoptotic index (AI), and ploidy status of the tumors. Material and Methods: A total of 87 NSCLCs were examined using immunohistochemical and molecular methods in order to estimate the status of the pRb-p53-MDM2 network. The kinetic parameters and the ploidy status of the tumors were assessed by in situ assays. The possible associations between alterations of the network, kinetic parameters and ploidy status of the carcinomas were assessed with a series of statistical methods. Results: Aberrant expression of pRb (Ab) and overexpression of p53 (P) and MDM2 (P) proteins were observed in 39%, 57%, and 68% of the carcinomas, respectively. The comprehensive analysis revealed that concurrent alterations in all three cell cycle regulatory molecules were the most frequent pattern, pRb(Ab)/p53(P)/MDM2(P); this “full abnormal” phenotype represented approximately 27% of the cases. This immunoprofile obtained the highest PI/AI value; whereas, the “normal” phenotype was the lowest one (p = 0.004). Furthermore, the pattern pRb(Ab)/p53(P)/MDM2(P) acquired the highest PI (p < 0.001) and lowest AI (p < 0.001) scores. Interestingly, the groups of carcinomas with impaired expression of one or two molecules attained PI/AI ratio values clustered in a narrow range placed in the middle of the scores exhibited by the “normal” and “full abnormal” phenotypes. These tumors had significantly lower AI, but similar PI values, compared with those noticed in the normal pattern. In addition, it was observed that the pRb(Ab)/p53(P)/MDM2(P) phenotype was also significantly associated with aneuploidy (p = 0.002) and a tendency was observed when the expression of two components was altered (p = 0.055). Conclusions: Our findings suggest that simultaneous deregulation of all members of the pRb-p53-MDM2 network confers an additive effect on tumor growth. The apoptotic pathway seems to be more susceptible to its defects than the cell proliferation machinery. The findings of the ploidy analysis, which are in parallel with those regarding the proliferative activity and the apoptotic rate study, further support the concept that these molecules constitute a tightly regulated network participating in cell cycle control and chromosomal stability.
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For further information contact us at helpdesk@openaire.eu36 citations 36 popularity Average influence Top 10% impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece Greek, Modern (1453-)Εθνικό Ιδρυμα Ερευνών (ΕΙΕ), Αθήνα, 2006 H παρούσα μελέτη αποσκοπεί να παρουσιάσει συνοπτικά τις διάφορες θεωρίες σχετικά με την προέλευση της ζωής και να εξηγήσει διάφορες πειραματικές μαρτυρίες που είναι σήμερα δημοσιευμένες. Γίνεται μια επιστημονική ξενάγηση από τον χρόνο μηδέν έως σήμερα και συζητούνται διάφορα ερωτήματα σχετικά με το πώς περίπου νομίζουμε ότι έχει προέλθει η ζωή στον πλανήτη μας. Η ζωή είναι συνυφασμένη με όλες τις ζωντανές υπάρξεις, με ή χωρίς συνείδηση, δημιουργήματα με πολύ ωραία χρώματα και εξαιρετική ποικιλία. Το ζωικό Βασίλειο αποτελείται από περισσότερα από δέκα εκατομμύρια είδη με εκπληκτική ποικιλομορφία. Στον πλανήτη μας μόνο, οι μικροοργανισμοί είναι περισσότεροι από ένα εκατομμύριο.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece EnglishEuropean Centre for Byzantine and Post-Byzantine monuments, 2006 Authors: Drakopoulou, Eugenia;Drakopoulou, Eugenia;207 p. : coloured icons, maps
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece EnglishWiley-Blackwell Publishing Ltd. Authors: Theodorou, Marina C.; Theodorou, E.C.; Panagiotidis, C.A.; Kyriakidis, D.A.;Theodorou, Marina C.; Theodorou, E.C.; Panagiotidis, C.A.; Kyriakidis, D.A.;Abstract Poster Presentation The AtoS-AtoC/Az two-component system activates the ato- DAEB operon expression upon acetoacetate induction for E. coli growth in short-chain fatty acids. It also enhances the poly (3- OH-butyrate) (cPHB) biosynthesis, upon acetoacetate induction as well as in the presence of spermidine. The response regulator of the system is the antizyme (Az) of ornithine decarboxylase and is the product of atoC gene. It belongs to the NtrC-NifA family of sigma54-RNA polymerase transcriptional activators. AtoC contains two putative phosphorylation sites, i.e. a conserved aspartic acid among the response regulators and a histidine residue in an H box consensus sequence, normally common to histidine kinases. We report here, that only phosphorylationcompetent AtoC can lead to enhanced production of cPHB in E. coli, when overexpressed with AtoS. Specifically, upon acetoacetate induction, the mutation of Asp reduces cPHB accumulation, compared with cells expressing wild-type AtoC. The mutation of His residue has an even more pronounced effect. The relative effects of these mutations on cPHB accumulation are consistent with their effects on atoDAEB operon expression, i.e. the mutation of Asp has a more potent phenotype than the substitution of His, in the presence of spermidine. Introduction of both AtoC mutations render the system unresponsive to acetoacetate as well as polyamine, resulting in total abrogation of the AtoS-AtoC/Az overexpression effect phenotype to cPHB levels in E. coli.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2010 Greece EnglishΑρχαιογνωσία, Αθήνα, 2006 All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1457::577c7253c8cec93753c45c5bd74f9412&type=result"></script>'); --> </script>
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2007 Greece, FranceSpringer Science and Business Media LLC Authors: Jalal Errami; Michel Peyrard; Nikos Theodorakopoulos;Jalal Errami; Michel Peyrard; Nikos Theodorakopoulos;pmid: 17728978
We report model calculations on DNA single strands which describe the equilibrium dynamics and kinetics of hairpin formation and melting. Modeling is at the level of single bases. Strand rigidity is described in terms of simple polymer models; alternative calculations performed using the freely rotating chain and the discrete Kratky-Porod models are reported. Stem formation is modeled according to the Peyrard-Bishop-Dauxois Hamiltonian. The kinetics of opening and closing is described in terms of a diffusion-controlled motion in an effective free energy landscape. Melting profiles, dependence of melting temperature on loop length, and kinetic time scales are in semiquantitative agreement with experimental data obtained from fluorescent DNA beacons forming poly(T) loops. Variation in strand rigidity is not sufficient to account for the large activation enthalpy of closing and the strong loop length dependence observed in hairpins forming poly(A) loops. Implications for modeling single strands of DNA or RNA are discussed. Comment: 15 pages, 17 figures, submitted to Eur. J. Phys. E
HELIOS Repository arrow_drop_down The European Physical Journal EArticle . 2007License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Average influence Average impulse Average Powered by BIP!
more_vert HELIOS Repository arrow_drop_down The European Physical Journal EArticle . 2007License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research produ