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  • Publication . Article . Preprint . 2021
    Open Access English
    Authors: 
    Florian Kabinger; Carina Stiller; Jana Schmitzová; Christian Dienemann; Goran Kokic; Hauke S. Hillen; Claudia Höbartner; Patrick Cramer;
    Publisher: Nature Publishing Group US
    Country: Germany
    Project: EC | illumizymes (682586)

    Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans. Here, w...

  • Publication . Part of book or chapter of book . Other literature type . 2015
    Open Access
    Authors: 
    Fernando Almazán; Silvia Márquez-Jurado; Aitor Nogales; Luis Enjuanes;
    Publisher: Springer New York
    Country: Spain
    Project: EC | EMPERIE (223498), NIH | PPG: SARS-CoV-host cell i... (2P01AI060699-06A1)

    The large size of the coronavirus (CoV) genome (around 30 kb) and the instability in bacteria of plasmids carrying CoV replicase sequences, represent serious restrictions for the development of CoV infectious clones using reverse genetic systems similar to those used fo...

  • Open Access
    Authors: 
    Reina S. Sikkema; Elmoubasher Farag; Sayed Himatt; Adel K Ibrahim; Hamad Al-Romaihi; Salih A. Al-Marri; Mohamed H. Al-Thani; Ahmed M. El-Sayed; Mohammed Al-Hajri; Bart L. Haagmans; +2 more
    Country: Netherlands
    Project: EC | PREPARE (602525), EC | COMPARE (643476)

    Abstract The transmission routes and risk factors for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown. We used the World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for human ME...

  • Open Access English
    Authors: 
    Helen Everett; Fabian Z. X. Lean; Alexander M. P. Byrne; Pauline M. van Diemen; Shelley G. Rhodes; Joe James; Benjamin C. Mollett; Vivien J Coward; Paul Skinner; Caroline J. Warren; +10 more
    Publisher: MDPI
    Project: EC | EVA-GLOBAL (871029)

    Ferrets were experimentally inoculated with SARS-CoV-2 (severe acute respiratory syndrome (SARS)-related coronavirus 2) to assess infection dynamics and host response. During the resulting subclinical infection, viral RNA was monitored between 2 and 21 days post-inocula...

  • Open Access English
    Authors: 
    Jasper S Johnston; Eloise S Johnston; Sebastian L. Johnston;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | MaeBAia (788575)

    AbstractCOVID-19 poses an immense and immediate threat to global public health. Population level interventions (PLIs) impact this threat, with estimable large effects on reducing mortality. Many countries worldwide have currently zero/low mortality and many have yet to ...

  • Open Access English
    Authors: 
    Anna Georgiadou; Ariadni Michalitsi-Psarrou; Fotios Gioulekas; Evangelos Stamatiadis; Athanasios Tzikas; Konstantinos Gounaris; Georgios Doukas; Christos Ntanos; Luís Landeiro Ribeiro; Dimitris Askounis;
    Publisher: MDPI
    Project: EC | SPHINX (826183)

    the domain suffering the most during the pandemic. This paper aims to assess the cybersecurity culture readiness of hospitals’ workforce during the COVID-19 crisis. Towards that end, a cybersecurity awareness webinar was held in December 2020 targeting Greek Healthcare ...

  • Open Access
    Authors: 
    Amitava Banerjee; Laura Pasea; Steve Harris; Arturo Gonzalez-Izquierdo; Ana Torralbo; Laura Shallcross; Mahdad Noursadeghi; Deenan Pillay; Christina Pagel; Wai Keong Wong; +4 more
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | BigData Heart (116074), WT

    BackgroundThe medical, health service, societal and economic impact of the COVID-19 emergency has unknown effects on overall population mortality. Previous models of population mortality are based on death over days among infected people, nearly all of whom (to date at ...

  • Publication . Other literature type . Article . 2021
    Open Access English
    Authors: 
    Fabrizio Gilardi; Theresa Gessler; Mael Kubli; Stefan Müller;
    Country: Switzerland
    Project: SNSF | Digital Democracy Lab (10DL11_183120), EC | PRODIGI (883121)

    We study the role of social media in debates regarding two policy responses to COVID-19 in Switzerland: face-mask rules and contact-tracing apps. We use a dictionary classifier to categorize 612'177 tweets by parties, politicians, and the public as well as 441'458 artic...

  • Open Access English
    Authors: 
    Horton, Daniel L.; McElhinney, Lorraine M.; Freuling, Conrad M.; Marston, Denise A.; Banyard, Ashley C.; Goharrriz, Hooman; Wise, Emma; Breed, Andrew C.; Saturday, Greg; Kolodziejek, Jolanta; +5 more
    Publisher: Public Library of Science
    Project: EC | EVA (228292)

    Author Summary Despite being one of the oldest recognised infectious diseases, rabies continues to cause thousands of preventable human deaths per year. As a zoonotic disease, control of infection in the reservoir has been proven the most efficient route to reduction of...

  • Open Access English
    Authors: 
    Sharon, Tamar;
    Country: Netherlands
    Project: EC | Digital Good (804985)

    AbstractSince the outbreak of COVID-19, governments have turned their attention to digital contact tracing. In many countries, public debate has focused on the risks this technology poses to privacy, with advocates and experts sounding alarm bells about surveillance and...