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  • Open Access English
    Authors: 
    Xuesong Wang; Willem Jespers; Brandon J. Bongers; Maria C.C. Habben Jansen; Chantal M. Stangenberger; Majlen A. Dilweg; Hugo Gutiérrez-de-Terán; Adriaan P. IJzerman; Laura H. Heitman; Gerard J. P. van Westen;
    Country: Netherlands

    In cancer, G protein-coupled receptors (GPCRs) are involved in tumor progression and metastasis. In this study we particularly examined one GPCR, the adenosine A2B receptor. This receptor is activated by high concentrations of its endogenous ligand adenosine, which supp...

  • Publication . Contribution for newspaper or weekly magazine . Part of book or chapter of book . Conference object . 2000
    Open Access English
    Authors: 
    Amnell, Tobias; Behrmann, Gerd; Bengtsson, Johan; D'Argenio, Pedro R.; David, Alexandre; Fehnker, Ansgar; Hune, Thomas; Jeannet, Bertrand; Larsen, Kim Guldstrand; Möller, M. Oliver; +7 more
    Countries: Netherlands, Denmark

    UPPAAL is a tool for modeling, simulation and verification of real-time systems, developed jointly by BRICS at Aalborg University and the Department of Computer Systems at Uppsala University. The tool is appropriate for systems that can be modeled as a collection of non...

  • Publication . Conference object . Contribution for newspaper or weekly magazine . Other literature type . 2017
    Open Access English
    Authors: 
    Toine Bogers; Marijn Koolen; Bamshad Mobasher; Alan Said; Alexander Tuzhilin;
    Publisher: Association for Computing Machinery
    Countries: Netherlands, Denmark

    Over the past decade, recommendation algorithms for ratings prediction and item ranking have steadily matured. However, these state-of-the-art algorithms are typically applied in relatively straightforward and static scenarios: given information about a user's past item...

  • Open Access English
    Authors: 
    Smolen, J. S.; Landewé, R.; Breedveld, F. C.; Dougados, M.; Emery, P.; Gaujoux-Viala, C.; Gorter, S.; Knevel, R.; Nam, J.; Schoels, M.; +25 more
    Countries: United Kingdom, Netherlands, Switzerland, Netherlands

    Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear and consensual international recommendations on RA treatment are not available. In this paper recommendations for the treatment of RA with synthetic and biological disease-modif...

  • Publication . Report . 2020
    Open Access English
    Authors: 
    Bernhard Wolfslehner; Helga Pülzl; Daniela Kleinschmit; Filip Aggestam; Georg Winkel; Jeroen J. L. Candel; Katarina Eckerberg; Peter H. Feindt; Constance L. McDermott; Laura Secco; +3 more
    Countries: Sweden, Netherlands

    Forests and forest-relevant policies in Europe face a wide array of challenges in a rapidly changing world. Issues such as Brexit, the new European Parliament and European Commission, and the recent European Green Deal proposal are certain to affact policymaking, as are...

  • Open Access English
    Authors: 
    R.J. Dekker; Piet B. W. Schwering; K.W. Benoist; Stefano Pignatti; Federico Santini; Ola Friman;
    Publisher: SPIE
    Country: Netherlands

    This paper studies change detection of LWIR (Long Wave Infrared) hyperspectral imagery. Goal is to improve target acquisition and situation awareness in urban areas with respect to conventional techniques. Hyperspectral and conventional broadband high-spatial-resolution...

  • Open Access English
    Authors: 
    Audrey Coutens; Jes K. Jørgensen; M. H. D. van der Wiel; Holger S. P. Müller; J. M. Lykke; Per Bjerkeli; Tyler Bourke; Hannah Calcutt; Maria Drozdovskaya; Cécile Favre; +8 more
    Countries: Netherlands, United Kingdom
    Project: EC | CHEMPLAN (291141), EC | S4F (646908)

    Formamide (NH$_2$CHO) has previously been detected in several star-forming regions and is thought to be a precursor for different prebiotic molecules. Its formation mechanism is still debated, however. Observations of formamide, related species and their isopotologues m...

  • Open Access English
    Authors: 
    Merckx, V.S.F.T.; Hendriks, K.P.; Beentjes, K.K.; Mennes, C.B.; Becking, L.E.; Peijnenburg, K.T.C.A.; Afendy, A.; Arumugam, N.; de Boer, H.; Biun, A.; +45 more
    Country: Netherlands

    Tropical mountains are hot spots of biodiversity and endemism,but the evolutionary origins of their unique biotas are poorlyunderstood. In varying degrees, local and regional extinction,long-distance colonization, and local recruitment may all contribute to the exceptio...

  • Open Access English
    Authors: 
    Santiago García-Burillo; Francoise Combes; C. Ramos Almeida; A. Usero; A. Alonso-Herrero; L. K. Hunt; D. Rouan; Susanne Aalto; Miguel Querejeta; S. Viti; +11 more
    Countries: Italy, France, Netherlands
    Project: EC | HIDDeN (789410)

    We investigate the fueling and the feedback of nuclear activity in the Seyfert 2 galaxy NGC1068, by studying the distribution and kinematics of molecular gas in the torus and its connections. We use ALMA to image the emission of a set of molecular gas tracers in the cir...

  • Open Access English
    Authors: 
    Binyamin Ben Avraham; Marisa G. Crespo-Leiro; Gerasimos Filippatos; Israel Gotsman; Petar M. Seferovic; Tal Hasin; Luciano Potena; Davor Miličić; Andrew J.S. Coats; Giuseppe M.C. Rosano; +31 more
    Countries: United Kingdom, Denmark, United Kingdom, Belgium, Netherlands, Spain, Sweden

    [Abstract] The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD-supported patients on the device and the scarcity of donor hea...