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  • Publication . Preprint . Article . 2021
    English
    Authors: 
    Nakamura, Gilberto M.; Plaszczynski, Stéphane; Grammaticos, Basile; Badoual, Mathilde;
    Publisher: HAL CCSD
    Country: France

    International audience; We study the effect of an emerging virus mutation on the evolution of an epidemic, inspired by the appearance of the delta variant of SARS-CoV-2. We show that if the new variant is markedly more infective than the existing ones the epidemic can r...

  • Open Access English
    Authors: 
    Cédric Gil-Jardiné; Gabrielle Chenais; Catherine Pradeau; Eric Tentillier; Philipe Revel; Xavier Combes; Michel Galinski; Eric Tellier; Emmanuel Lagarde;
    Country: France

    Abstract Objectives During periods such as the COVID-19 crisis, there is a need for responsive public health surveillance indicators related to the epidemic and to preventative measures such as lockdown. The automatic classification of the content of calls to emergency ...

  • Open Access English
    Authors: 
    Andrew E. Clark; Conchita D'Ambrosio; Anthony Lepinteur;
    Publisher: HAL CCSD
    Countries: Luxembourg, France

    We here use panel data from the COME-HERE survey to track income inequality during COVID-19 in France, Germany, Italy, and Spain. Relative inequality in equivalent household disposable income among individuals changed in a hump-shaped way between January 2020 and Januar...

  • Open Access English
    Authors: 
    Peter Czuppon; Florence Débarre; Antonio Gonçalves; Olivier Tenaillon; Alan S. Perelson; Jeremie Guedj; François Blanquart;
    Publisher: HAL CCSD
    Country: France
    Project: ANR | TheraCoV (ANR-20-COVI-0018), ANR | TheoGeneDrive (ANR-19-CE45-0009), EC | PolyPath (844369)

    Abstract Repurposed drugs that are immediately available and have a good safety profile constitute a first line of defense against new viral infections. Despite a limited antiviral activity against SARS-CoV-2, several drugs serve as candidates for application, not only ...

  • Open Access English
    Authors: 
    Franziska Hufsky; Kevin Lamkiewicz; Alexandre Almeida; Abdel Aouacheria; Cecilia N. Arighi; Alex Bateman; Jan Baumbach; Niko Beerenwinkel; Christian Brandt; Marco Cacciabue; +45 more
    Countries: Germany, Belgium, France, France, Belgium, Denmark, Argentina, Switzerland
    Project: EC | FeatureCloud (826078), UKRI | Rfam: The community resou... (BB/S020462/1), UKRI | Capacity building for bio... (BB/P027849/1), NIH | UniProt supporting an int... (3U24HG007822-05S1), UKRI | Bilateral NSF/BIO-BBSRC:A... (BB/N018354/1), WT | University of Edinburgh -... (203783), EC | EpiPose (101003688), EC | REPO-TRIAL (777111)

    SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly f...

  • English
    Authors: 
    Maurel Ribes, Agnès; Bessière, Pierre; Guéry, Jean Charles; Joly Featherstone, Eloïse; Bruel, Timothée; Robinot, Remy; schwartz, olivier; Abravanel, Florence; Izopet, Jacques; Joly, Etienne;
    Publisher: HAL CCSD
    Country: France

    Serological tests are important for understanding the physiopathology and following the evolution of the Covid-19 pandemic. Assays based on flow cytometry (FACS) of tissue culture cells expressing the spike (S) protein of SARS-CoV-2 have repeatedly proven to perform sli...

  • Open Access English
    Authors: 
    Bonnet, E.; Bodson, O.; Le Marcis, F.; Faye, A.; Sambieni, N. E.; Fournet, F.; Boyer, F.; Coulibaly, A.; Kadio, K.; Diongue, F. B.; +1 more
    Publisher: HAL CCSD
    Country: France

    Abstract Background: In early March 2020, the COVID-19 pandemic hit West Africa. Countries in the region quickly set up crisis management committees and organised drastic measures to stem the spread of the coronavirus. The objective of this article is to analyse the epi...

  • Open Access English
    Authors: 
    Penner, Robert; Baalen, Minus van;
    Publisher: HAL CCSD
    Country: France

    A possible explanation based on first principles for the appearance of the Omicron variant of the SARS-CoV-2 virus is proposed involving coinfection with HIV. The gist is that the resultant HIV-induced immunocompromise allows SARS-CoV-2 greater latitude to explore its o...

  • English
    Authors: 
    Bleher, Michael; Hahn, Lukas; Patiño-Galindo, Juanángel; Carriere, Mathieu; Bauer, Ulrich; Rabadán, Raúl; Ott, Andreas;
    Publisher: HAL CCSD
    Country: France

    The COVID-19 pandemic has lead to a worldwide effort to characterize its evolution through the mapping of mutations in the genome of the coronavirus SARS-CoV-2. As the virus spreads and evolves it acquires new mutations that could have important public health consequenc...

  • Open Access English
    Authors: 
    Trapman, Pieter; Ball, Frank; Dhersin, Jean-Stéphane; Tran, Viet Chi; Wallinga, Jacco; Britton, Tom;
    Countries: United Kingdom, France, United Kingdom
    Project: ANR | CEMPI (ANR-11-LABX-0007)

    When controlling an emerging outbreak of an infectious disease, it is essential to know the key epidemiological parameters, such as the basic reproduction number R 0 and the control effort required to prevent a large outbreak. These parameters are estimated from the ob...