International audience; A novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly spread worldwide. As no approved therapeutics exists to treat COVID-19, the disease associated to SARS-Cov-2, there is an urgent need to propose molecules that could quic...

The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy do...

Testing is a crucial control mechanism in the beginning phase of an epidemic when the vaccines are not yet available. It enables the public health authority to detect and isolate the infected cases from the population, thereby limiting the disease transmission to suscep...

International audience; In December 2019, the first case of infection with a new virus COVID-19 (SARS-CoV-2), named coronavirus, was reported in the city of Wuhan, China. At that time, almost nobody paid any attention to it. The new pathogen, however, fast proved to be ...

International audience; Motivated by the COVID-19 pandemic, we introduce a mathematical description of the impact of sociality in the spread of infectious diseases by integrating an epidemiological dynamic with a kinetic modeling of population-based contacts. The kineti...

Due to COVID19 pandemic, the 12th edition is cancelled. The LREC 2020 Proceedings are available at http://www.lrec-conf.org/proceedings/lrec2020/index.html; International audience; In this article, we will introduce two of the new parts of the new multi-part version of ...

Summary: Computational models of biological systems can exploit on a broad range of rapidly developing approaches, including novel experimental approaches, bioinformatics data analysis, emerging modelling paradigms, data standards, and algorithms. A discussion about the...

Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant wo...

We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort t...

International audience