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  • Open Access English
    Authors: 
    Rubén Gómez-Sánchez; Jaqueline Rose; Rodrigo Soares Guimaraes; Muriel Mari; Daniel Papinski; Ester Rieter; Willie J. C. Geerts; Ralph Hardenberg; Claudine Kraft; Christian Ungermann; +1 more
    Country: Netherlands
    Project: NWO | A three-dimensional look ... (2300175771), FWF | Architecture and function... (P 25522), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), FWF | Mechanisms and hierarchy ... (P 28113), NWO | The role of autophagy in ... (2300175628), EC | AutophagosomeSealing (655027)

    The autophagy-related (Atg) proteins play a key role in the formation of autophagosomes, the hallmark of autophagy. The function of the cluster composed by Atg2, Atg18, and transmembrane Atg9 is completely unknown despite their importance in autophagy. In this study, we...

  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • Open Access
    Authors: 
    Hollenstein, David M.; Gómez-Sánchez, Rubén; Ciftci, Akif; Kriegenburg, Franziska; Mari, Muriel; Torggler, Raffaela; Licheva, Mariya; Reggiori, Fulvio; Kraft, Claudine;
    Project: NWO | A three-dimensional look ... (2300175771), FWF | Mechanisms and hierarchy ... (P 28113), EC | DRIVE (765912), EC | AutoClean (769065), EC | PRONKJEWAIL (713660), FWF | Signaling Mechanisms in C... (W 1261), FWF | Architecture and function... (P 25522)

    ABSTRACT Autophagy is initiated by the formation of a phagophore assembly site (PAS), the precursor of autophagosomes. In mammals, autophagosome formation sites form throughout the cytosol in specialized subdomains of the endoplasmic reticulum (ER). In yeast, the PAS is...

  • Open Access English
    Authors: 
    Alessia Landi; Muriel Mari; Tobias Wolf; Svenja Kleiser; Christine Gretzmeier; Isabel Wilhelm; Dimitra Kiritsi; Roland Thuenauer; Roger Geiger; Alexander Nyström; +3 more
    Publisher: Life Science Alliance LLC
    Country: Netherlands
    Project: EC | LEC&LIP2INVADE (282105), NWO | A three-dimensional look ... (2300175771), EC | DRIVE (765912), EC | PRONKJEWAIL (713660)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

  • Open Access English
    Authors: 
    Jieqiong Gao; Fulvio Reggiori; Christian Ungermann;
    Country: Netherlands
    Project: NWO | A three-dimensional look ... (2300175771), NWO | The role of autophagy in ... (2300175628), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a catabolic pathway that delivers intracellular material to the mammalian lysosomes or the yeast and plant vacuoles. The final step in this process is the fusion of autophagosomes with vacuoles, which requires SNARE proteins, the homotypic vacuole fusion an...

  • Open Access English
    Authors: 
    Yingying Cong; Pauline Verlhac; Fulvio Reggiori;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...