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Fold change (FC ≤ 1.5) list and GO enrichment analysis of probes affected by IHNV status.

This dataset contains synthetic data from simulations (for a total duration of 10 minutes) including the activity of one multi-unit and two single-units for different firing rates and signal-to-noise ratio levels. It is intended to be used as a standardized dataset to evaluate spike sorting algorithms. Recordings were taken using a sampling rate of 24 kHz, and are comprised of spikes from a database with 594 different average spike shapes, taken from real recordings from monkey neocortex and basal ganglia. This dataset is comprised of two files: data.npy and labels.csv. data.npy contains 14,400,000 sampled voltage values, from a single channel, taken at a sampling rate of 24 kHz. labels.csv contains the timestep, spike class, amplitude (SNR), and firing rate associated with each spiking event. The original samples used to construct this dataset where previously constructed and made available in [1]. This dataset is an amalgamation of simulation files, which were previously publicly accessible at: http://www2.le.ac.uk/departments/engineering/research/bioengineering/neuroengineering-lab/software. Consequently, when using or making modifications to this dataset, in addition to acknowledging this record, [1] must also be acknowledged, as per the original author's request. [1] J. Martinez, C. Pedreira, M. J. Ison, and R. Quian Quiroga, ���Realistic simulation of extracellular recordings,��� Journal of Neuroscience Methods, vol. 184, no. 2, pp. 285���293, Nov. 2009, doi: 10.1016/j.jneumeth.2009.08.017. {"references": ["J. Martinez, C. Pedreira, M. J. Ison, and R. Quian Quiroga, \"Realistic simulation of extracellular recordings,\" Journal of Neuroscience Methods, vol. 184, no. 2, pp. 285\u2013293, Nov. 2009, doi: 10.1016/j.jneumeth.2009.08.017."]}

Table S1. Next-generation sequencing results of erythrocyte microRNAs for 9 healthy controls and 9 relapsing-remitting Multiple Sclerosis patients. (XLSX 27Â kb)

Multivariate structural MRI templates and quantitative atlases from multi-echo T2 relaxation (GRASE images, MWF quantitative maps) and steady-state (mcDESPOT/IRSPGR images, fM quantitative maps) myelin water imaging approaches, along with regions of interest generated and analyzed for Myelin imaging in the central nervous system: Comparison of multi-echo T2 relaxation and steady-state approaches

Numerous studies have been performed to examine gene expression patterns in the rodent hippocampus in the kindling model of epilepsy. However, recent reviews of this literature have revealed limited agreement among studies. Because this conclusion was based on retrospective comparison of reported "hit lists" from individual studies, we hypothesized that re-analysis of the original expression data would help address this concern. In this paper, we reanalyzed four genome-wide expression studies of excitotoxin-induced kindling in rat and performed a statistical meta-analysis. The meta-analysis revealed over 800 genes which show significant change in expression 24 h after initial seizure induction, and 59 genes altered after 10 days. To evaluate our results in light of previous work, we assembled a reference list of genes formed from a consensus of the published literature. Our profiles include most of the genes in this reference list, and most of the additional genes are from pathways or biological processes previously recognized to be altered in kindling. In addition our results emphasized expression changes in lipid metabolism and protein degradation pathways. We conclude that a cautious re-analysis of published expression data can help illuminate genes and pathways underling kindling. Supplementary Material is available at http://www.chibi.ubc.ca/faculty/pavlidis/meta-analysis-of-brain-kindling/. http://hdl.handle.net/11272/10553

Abstract Background Transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a Ca2+-binding protein that regulates Ca2+ homeostasis through gene regulation and protein-protein interactions. It has been shown that a dominant active form (daDREAM) is implicated in learning-related synaptic plasticity such as LTP and LTD in the hippocampus. Neuronal spines are reported to play important roles in plasticity and memory. However, the possible role of DREAM in spine plasticity has not been reported. Results Here we show that potentiating DREAM activity, by overexpressing daDREAM, reduced dendritic basal arborization and spine density in CA1 pyramidal neurons and increased spine density in dendrites in dentate gyrus granule cells. These microanatomical changes are accompanied by significant modifications in the expression of specific genes encoding the cytoskeletal proteins Arc, Formin 1 and Gelsolin in daDREAM hippocampus. Conclusions Our results strongly suggest that DREAM plays an important role in structural plasticity in the hippocampus.

Abstract Multiple studies have corroborated the restoration of volitional motor control after motor-complete spinal cord injury (SCI) through the use of epidural spinal cord stimulation (eSCS), but rigorous quantitative descriptions of muscle coordination have been lacking. Six participants with chronic, motor and sensory complete SCI underwent a brain motor control assessment (BMCA) consisting of a set of structured motor tasks with and without eSCS. We investigated how muscle activity complexity and muscle synergies changed with and without stimulation. We performed this analysis to better characterize the impact of stimulation on neuromuscular control. We also recorded data from nine healthy participants as controls. Competition exists between the task origin and neural origin hypotheses underlying muscle synergies. The ability to restore motor control with eSCS in participants with motor and sensory complete SCI allows us to test whether changes in muscle synergies reflect a neural basis in the same task. Muscle activity complexity was computed with Higuchi Fractal Dimensional (HFD) analysis, and muscle synergies were estimated using non-negative matrix factorization (NNMF) in six participants with American Spinal Injury Association (ASIA) Impairment Score (AIS) A. We found that the complexity of muscle activity was immediately reduced by eSCS in the SCI participants. We also found that over the follow-up sessions, the muscle synergy structure of the SCI participants became more defined, and the number of synergies decreased over time, indicating improved coordination between muscle groups. Lastly, we found that the muscle synergies were restored with eSCS, supporting the neural hypothesis of muscle synergies. We conclude that eSCS restores muscle movements and muscle synergies that are distinct from those of healthy, able-bodied controls.

Cet ensemble de données présente des informations sur les taux d'occurrence d'accidents vasculaires cérébraux selon l'âge et le sexe en Alberta, exprimés pour 100 000 habitants. This dataset presents information on age-sex specific occurrence rates of stroke for Alberta, expressed as per 100,000 population.

Additional file 4. Histological assessments for Figure 4. Shown are the data for each animal at either 1d or 3d post a single mild ischemic insult. Positive staining counts for TNF, Iba1 and EBA in addition to the Lectin scores and IgG gray level measures are presented.