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The ACLeeve is a portable and easy to use electromyography (EMG) device to be used during ACL injury recovery to aid in the rehabilitation process. The ACLeeve is wrapped around the user's leg using a knee sleeve and electrodes, and then wirelessly transfers data to the user's phone or laptop. To achieve this, the ACLeeve must be small and lightweight, with electronics and software capable of detecting EMG readings and then transmitting them over a secure wireless connection. As well, the ACLeeve must be safe for the user and conform to all relevant standards. ACLeeve will monitor the user's movements of both quadriceps using surface EMGs (SEMGs) and Strain Sensors. These devices will be actively transmitting the collected data to a microprocessor, which will then process and send the data to an external device for further software analysis. The ACLeeve will provide real-time feedback to the user (audio or visual) regarding the performance of their movements, which will allow the user to physically adjust in order to achieve better long-term results.Our software will perform long-term analyses which will evaluate the progress of obtaining the goal of 80-90% asymmetry between the user's ACL-injured quadricep and their other healthy quadricep.

Although a number of cytoskeletal derangements have been described in the setting of traumatic axonal injury (TAI), little is known of early structural changes that may serve to initiate a cascade of further axonal degeneration. Recent work by the authors has examined conformational changes in cytoskeletal constituents of neuronal axons undergoing traumatic axonal injury (TAI) following focal compression through confocal imaging data taken in vitro and in situ. The present study uses electron microscopy to understand and quantify in vitro alterations in the ultrastructural composition of microtubules and neurofilaments within neuronal axons of rats following focal compression. Standard transmission electron microscopy processing methods are used to identify microtubules, while neurofilament identification is performed using antibody labeling through gold nanoparticles. The number, density, and spacing of microtubules and neurofilaments are quantified for specimens in sham Control and Crushed groups with fixation at <1min following load. Our results indicate that the axon caliber dependency known to exist for microtubule and neurofilament metrics extends to axons undergoing TAI, with the exception of neurofilament spacing, which appears to remain constant across all Crushed axon diameters. Confidence interval comparisons between Control and Crushed cytoskeletal measures suggests early changes in the neurofilament spatial distributions within axons undergoing TAI may precede microtubule changes in response to applied loads. This may serve as a trigger for further secondary damage to the axon, representing a key insight into the temporal aspects of cytoskeletal degeneration at the component level, and suggests the rapid removal of neurofilament sidearms as one possible mechanism.

Low health literacy (HL) increases the risk of adverse stroke-related health outcomes. The aim of this review was to identify 1. what the quality and what the limitations to educational materials used to improve HL in stroke patients are 2. what the levels of HL among stroke patients and stroke survivors are, and 3. how HL and stroke literacy levels affect health-related behaviours and outcomes of stroke patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. 6 computerized databases and gray literature sources were searched: MEDLINE, OVID, EMBSE, CINAHL, Cochrane library, Web of Science, and Health and Psychosocial Instruments, and Google Scholar. Papers published in English between January 01, 2000 and August 01, 2020 were included. Five themes were identified across the 26 studies regarding the education and measurement of stroke with relevance to HL. This review concludes that current instruments used to improve HL in stroke are inadequate as they fail to provide a holistic assessment of health literacy, especially concerning stroke patients and stroke literacy. This review identified a paucity of literature on HL in relation to stroke management and outcomes. Therefore, the authors are in strong favour of future research prioritizing the development of effective tools to assess HL and develop best-practice guidelines for stroke education materials.

Example code for the multivariate template creation process used for Myelin imaging in the central nervous system: Comparison of multi-echo T2 relaxation and steady-state approaches

Release Notes Minor release, incorporate major bug fixes and recommendations from OHBM meeting. CHANGES [FIX] unique already creates an index, unique made a repetitive index (#600) @jdkent [ENH] add base_study attribute (#599) @jdkent [FIX] ignore string if doi/pmid/name string is empty (#598) @jdkent [ENH] add conditions and weights to specification (#597) @jdkent [ENH] add studyset-references endpoint (#596) @jdkent chore(deps): bump @cypress/request and cypress in /compose/neurosynth-frontend (#595) @dependabot 197 display user icon name (#591) @nicoalee [ENH] add username and neurostore studyset script (#590) @jdkent [FIX] nick feedback (#589) @jdkent [ENH] add usernames to compose (#588) @jdkent [MAINT] update openapi to main branch (#586) @jdkent [ENH] bulk upload (#585) @jdkent 565 update the advanced search input (#583) @nicoalee [ENH] add username as resource attribute (#584) @jdkent 561 switch api from studies to abstract studies (#582) @nicoalee [FIX] id not showing up for info=true (#581) @jdkent [ENH] using an iterator over a list comprehension should be faster (#578) @jdkent [FIX] add data_type to base_study (#577) @jdkent [FIX] info query param behavior (#576) @jdkent [ENH] make it quicker to filter studies by whether they have images/points. (#574) @jdkent chore(deps): bump tough-cookie and @cypress/request in /compose/neurosynth-frontend (#569) @dependabot

Release Notes Update licensing for zenodo integration Changes [FIX] Update license and license fields (#117)

The main organ of the human central nervous system, the human brain, is one of the most complex organs in the human body. The causes of many brain diseases and disorders, such as Alzheimer’s disease, and their ideal treatments are still not fully understood with the current medical technology. With medical imaging techniques such as magnetic resonance imaging (MRI), magnetoencephalography (MEG), and electroencephalography (EEG), the data obtained from these techniques can be used to study and examine brain diseases and disorders. This project focuses on utilizing a surface registration method on multiple brain surfaces to obtain various geometric transformations for brain studies, and the implementation of the analysis pipeline on a high performance computing (HPC) environment. Due to the infeasibility on runtime for performing surface registration between one template brain surface and multiple target brain surfaces, an approach to perform sub-surface extraction on each brain surface and computation on a HPC environment has been employed. This has allowed a significant reduction in runtime and has also allowed the results to be obtained within reasonable time.

bidspm is a set of pipelines and tools for Octave / MATLAB to process and analyze BIDS data sets using SPM12. Please check the code at: https://github.com/cpp-lln-lab/bidspm

Diagnosed in 2009 with Multiple Sclerosis, my mother’s mental and physical health deteriorated at a rapid pace. The person who raised me was altered, becoming someone who was less confident in her abilities and saw her disease as a defeat. I grew to resent this new person, seeing her as the other; as someone who is no longer what she once was. The fear of losing yourself, of becoming another, or of being destroyed by the other is present within my work. We experience anxiety in the face of something uncertain and indefinite, but in spite of this, I choose to speak about the effects this disease has had on my mother, family and self. By combining methods of collage and painting, I attempt to create a visual correlation of my mother’s physical and mental states with my own experience of the disease. Multiple Sclerosis affects the immune system by attacking and destroying myelin cells that surround the nerves, which distort or blocks the messages traveling along it, weakening the transmission to the muscles in the body. The severity of this disease has deformed my mother’s body physically. Due to MS, my mother is seen as abject. A rejection of society’s ideals of classical beauty due to her saggy skin, wrinkled face, and curved spine becoming a spectacle of horror. The transformation of her middle-aged body reveals the bones and tiny frame of a woman who has experienced trauma and has decayed into something most healthy bodies fear. I am reflecting on embodiment in these works, on impermanent definitions of the self. Within my practice I am using photography and collage as a way to unveil new identities of myself, mother and siblings that reflect upon our fears of the disease and not being able to rid ourselves from it. Focusing on a biological aspect of matrophobia, I have taken distinctive features of my mother that we share and made disturbing portraits that represent one possible future of our flesh and hers. We belong to her, we come from her flesh, and we now face the possibility of becoming her, of becoming the other. The physical act of removing the collaged transfers of our portraits presents an uncanny experience of my mother to me. Her image becomes disturbing and also familiar because it is presented as her, but is not her. We are presented as her, but we are not her or ourselves. When I reveal the new identities of each of us, I encounter memories of the woman we came from, but then face the reality of whom she is now and who we may become, the diseased mother, the diseased flesh, that I find difficult to engage with fully. Externalizing the internal disease, I have created bodily forms in a tangible way that act as the metaphors for the disease on both the canvas and in space. These forms, which have taken on a life of their own, reflect the marks, bruises, and anxieties of something uncontrollable and out of reach. Psychoanalytic theory suggests that only through mourning can a separation take place that is a necessary to the development of the individual. Freud thought that mourning is based on a process through which an object could only be given up if in some sense it became part of the subject’s self. By projecting the other self of my mother into these forms, I attempt to heal and to rid myself of the unwanted part of her that is seen as vile, haunting, and grotesque. Color serves as an emotional response that describes affective qualities of itself. I use color in two ways: it serves as a way to speak to my mother’s cognitive reasoning and my encounter with the other as plastic and cold. When choosing the colors, I focused on using high chroma colors to reflect the undesirable side effects of prescription medication my mother was on, which altered her perception of everyday life. As well, I chose colors that are not seen in our daily life, becoming another form of this alternate reality both portraits and beings exist in. Color becomes 4a distraction that presents a joyful facade, attracting the gaze to confront the darkness of our situation through a seemingly paradoxical vibrancy, boldness and embellishment. The "other" is unknowable, incapable of being known by the self. I choose to embrace my relationship with my mother, acknowledging the difficulties it poses to our family. Through my vulnerability, humility, and acceptance of her, I am able to speak about living with someone who has multiple sclerosis and the fears we face alongside it. By working in a collaborative effort with my mother, I am able to translate the journey of her illness and better understand her as she is now.