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Tem-se por objetivo mapear as políticas da Rede Estadual de Educação do Rio de Janeiro na oferta de atividades pedagógicas não presenciais durante a primeira onda da Covid-19, analisando as condições de trabalho docente nesse período. Trata-se de estudo exploratório, com 22 professores atuantes em turmas de Ensino Médio. A coleta de dados foi realizada através de aplicação de questionário remoto, com estrutura de respostas semiestruturadas e fechadas. Os resultados parciais apontaram para baixa frequência de políticas públicas nacionais de regulamentação do acesso remoto, sendo predominantes políticas descentralizadas pelas Unidades da Federação. Os docentes apontaram para discrepâncias entre políticas públicas anunciadas pelo governo do estado e sua efetivação.

ZusammenfassungFür Patienten und Patientinnen mit Asthma wird eine Impfung gegen COVID-19 empfohlen. Dies gilt auch für Patienten und Patientinnen mit schwerem Asthma. Die Behandlung des schweren Asthmas mit einem Biologikum ist keine Kontraindikation für eine Impfung gegen COVID-19.

Voclosporin (Lupkynis

Abstract Background Experiences from the first wave of the 2019 coronavirus disease (COVID-19) pandemic can aid in the development of future preventive strategies. To date, risk prediction models for COVID-19-related incidence and outcomes in hemodialysis (HD) patients are missing. Methods We developed risk prediction models for COVID-19 incidence and mortality among HD patients. We studied 38 256 HD patients from a multi-national dialysis cohort between 3 March and 3 July 2020. Risk prediction models were developed and validated, based on predictors readily available in outpatient HD units. We compared mortality among patients with and without COVID-19, matched for age, sex and diabetes. Results During the observational period, 1259 patients (3.3%) acquired COVID-19. Of these, 62% were hospitalized or died. Mortality was 22% among COVID-19 patients with odds ratios 219.8 [95% confidence interval (CI) 80.6–359] to 342.7 (95% CI 60.6–13 595.1), compared to matched patients without COVID-19. Since the first wave of the pandemic affected most European countries during the study, the risk prediction model for incidence of COVID-19 was developed and validated in European patients only [N = 22 826 area under the ROC curve(AUC)Dev 0.64, AUCVal 0.69]. The model for prediction of mortality was developed in all COVID-19 patients (AUCDev 0.71, AUCVal 0.78). Angiotensin receptor blockers were independently associated with a lower incidence of COVID-19 in European patients. Conclusions We identified modifiable risk factors for COVID-19 incidence and outcome in HD patients. Our risk prediction tools can be readily applied in clinical practice. This can aid in the development of preventive strategies for future waves of COVID-19.

Porcine circovirus type 2 (PCV2) is the causal agent of postweaning multisystemic wasting syndrome (PMWS), causing large economical losses of the global swine industry. Nitric oxide (NO), as an important signaling molecule, has antiviral activity on some viruses. To date, there is little information on the role of NO during PCV2 infection.We used indirect fluorescence assay (IFA), TCIDOur findings indicate that the form of NO