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  • Authors: J.-C. Mauduit , et al; including J. S. Dunlop ,;
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lum, S; Sonnappa, S; Wade, A; Harding, S; +13 Authors

    The Size and Lung function In Children (SLIC) study was designed as a prospective, cross-sectional and longitudinal study to investigate the factors contributing to ethnic differences in lung function. After adjusting for sex, age and height, the degree to which these differences can be reduced after further adjustment for body shape, size and composition was examined. The aim of this technical report is to describe the study design and protocol and to examine the feasibility of conducting complex physiological investigations in London primary schools. Methods: Recruitment and assessments were undertaken in London primary schools. Children with parental consent were eligible and categorised into 4 broad ethnic groups: White; Black; South-Asian and other/mixed ethnicities. Assessments were performed in children aged 5-11y, on 2 occasions a year apart and included detailed anthropometry; 3D photonic scanning for regional body shape; body composition using bioelectrical impedance analysis and isotope dilution technique; spirometry and saliva samples (for cotinine & DNA analysis of genetic ancestry). Information on country of origin (child-parents-grandparents); self-reported ethnicity; the child’s respiratory history, family socio-economic circumstances and tobacco smoking exposure were obtained, principally from parents via a questionnaire. Health status of the children was verified from medical records where feasible. Data linkages to pollution index and area deprivation scores were based on home postcodes. Results: Fourteen London primary schools participated with 52% parental consent for children to take part in the study. Consent rate for each type of assessment was generally high and ranged from near 100% for spirometry and anthropometry to 88% for DNA sample collection. With the exception of 3D scanning for body shape, where acceptable data were only achieved in 68% children assessed, success rate for all assessments ranged from 88% to 99%. In total, 2171 (47% boys; 34% White; 29% Black; 25% South-Asian; 12% Other/mixed) children were assessed on 3302 test occasions over the two year period, with successful spirometry being achieved in 90% (2986/3302) of assessments. After excluding 20% of children with acute or chronic illness and 10% with failed spirometry, data was available from 1520 healthy children for final analysis. Summary: This is the first study to demonstrate the feasibility (in terms of consent and success rate) of undertaking complex physiological assessments within the school environment in children as young as 5 years of age, including those for DNA. However, until software is refined and adapted for children, current technology for performing 3D scans for health related studies is not cost-effective. Approximately 30% of the children studied were preterm/LBW, had prior asthma or were symptomatic. Hence if the target population is healthy young children then the recruited sample size may need to be increased by 30% to ensure adequate power.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ UCL Discoveryarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    UCL Discovery
    Report . 2014
    Data sources: UCL Discovery
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ UCL Discoveryarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      UCL Discovery
      Report . 2014
      Data sources: UCL Discovery
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    Authors: Aad, G; Abbott, B; Abdallah, J; Khalek, SA; +206 Authors

    A search is presented for direct top squark pair production using events with at least two leptons including a same-flavour opposite-sign pair with invariant mass consistent with the [Formula: see text] boson mass, jets tagged as originating from [Formula: see text]-quarks and missing transverse momentum. The analysis is performed with proton-proton collision data at [Formula: see text] collected with the ATLAS detector at the LHC in 2012 corresponding to an integrated luminosity of 20.3 fb[Formula: see text]. No excess beyond the Standard Model expectation is observed. Interpretations of the results are provided in models based on the direct pair production of the heavier top squark state ([Formula: see text]) followed by the decay to the lighter top squark state ([Formula: see text]) via [Formula: see text], and for [Formula: see text] pair production in natural gauge-mediated supersymmetry breaking scenarios where the neutralino ([Formula: see text]) is the next-to-lightest supersymmetric particle and decays producing a [Formula: see text] boson and a gravitino ([Formula: see text]) via the [Formula: see text] process.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: S. Chatrchyan; V. Khachatryan; A.  .M. Sirunyan; A. Tumasyan; +200 Authors

    A peaking structure in the J/ψφ mass spectrum near threshold is observed in B →J/ψφK decays, produced in pp collisions at √s=7 TeV collected with the CMS detector at the LHC. The data sample, selected on the basis of the dimuon decay mode of the J/ψ, corresponds to an integrated luminosity of 5.2 fb. Fitting the structure to an S-wave relativistic Breit-Wigner lineshape above a three-body phase-space nonresonant component gives a signal statistical significance exceeding five standard deviations. The fitted mass and width values are m = 4148.0 ± 2.4 (stat.) ± 6.3 (syst.)MeV and Γ=28 (stat.)±19(syst.)MeV, respectively. Evidence for an additional peaking structure at higher J/ψφ mass is also reported. © 2014 The Authors.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivio della Ricer...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; +549 Authors

    On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of $\sim$1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg$^2$ at a luminosity distance of $40^{+8}_{-8}$ Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Msun. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at $\sim$40 Mpc) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over $\sim$10 days. Following early non-detections, X-ray and radio emission were discovered at the transient's position $\sim$9 and $\sim$16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. (Abridged) The astrophysical journal / 2 848(2), L12 (2017). doi:10.3847/2041-8213/aa91c9 Published by IOP Publ., London

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    https://doi.org/10.5445/ir/100...
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    Article . 2017
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    Article . 2017
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    Article . 2017
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    KITopen
    Article . 2017
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    https://doi.org/10.48550/arxiv...
    Article . 2017
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    Authors: Conradie, Jeanet; Wamser, Carl C.; Ghosh, Abhik;

    A detailed TDDFT study (with all-electron STO-TZ2P basis sets and the COSMO solvation model) has been carried out on the effect of diprotonation on the UV-vis-NIR spectra of free-base tetraphenylporphyrin and tetrakis(

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    Authors: Kostas N. Syrigos; Alexios S Strimpakos; Muhammad Wasif Saif;

    Despite advances and investments in translation research, clinical trials and health service in general, there is no significant impact on the survival of most patients diagnosed with advanced pancreatic adenocarcinoma. It is broadly recognized though that there is a small minority of patients who really benefit from particular treatments for reason usually not well understood. Light to this fact is gradually shed by developments in the field of pharmacogenomics, which plays pivotal role in what we call individualized medicine. In that perspective, it is of most importance to present the significant developments in pharmacogenomics announced in the recent 2013 American Society of Clinical Oncology Annual Meeting. First, the predictive role of hENT1, which codes for a gemcitabine transporter into cells, was highlighted and might help us decide whether we benefit from gemcitabine or 5-fluorouracil in the adjuvant setting (Abstract #4006). Second, authors presented the negative predictive role of SPARC stroma and cytoplasmic expression in patients treated with adjuvant gemcitabine (within the CONCO-001 study) as they reported poor outcome of those having high expression, not seen in patients on observation (Abstract #4016). Finally, a study which might be a basis for future strategies and as great food for scientific thought suggested that selection of cytotoxic treatment based on gene expression profiling is feasible in clinical practice and may help improve treatment efficacy as well as predict for drug resistance (Abstract #4017). Of course, there is a long way to go before implementation of these genomic findings, with the exception of hENT1 which seems to be close for clinical use. JOP. Journal of the Pancreas, Vol 14, N° 4 (2013): July - p. 304-474

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    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.

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    Authors: Christopher John Atherton; Thomas Barton; Jim Basney; Daan Broeder; +36 Authors

    The authors also acknowledge the support and collaboration of many other colleagues in their respective institutes, research communities and IT Infrastructures, together with the funding received by these from many different sources. These include but are not limited to the following: (i) The Worldwide LHC Computing Grid (WLCG) project is a global collaboration of more than 170 computing centres in 43 countries, linking up national and international grid infrastructures. Funding is acknowledged from many national funding bodies and we acknowledge the support of several operational infrastructures including EGI, OSG and NDGF/NeIC. (ii) EGI acknowledges the funding and support received from the European Commission and the many National Grid Initiatives and other members. EOSC-hub receives funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 777536. (iii) The work leading to these results has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 730941 (AARC2). (iv) Work on the development of ESGF's identity management system has been supported by The UK Natural Environment Research Council and funding from the European Union's Seventh Framework Programme for research, technological development and demonstration through projects IS-ENES (grant agreement no 228203) and IS-ENES2 (grant agreement no 312979). (v) Ludek Matyska and Michal Prochazka acknowledge funding from the RI ELIXIR CZ project funded by MEYS Czech Republic No. LM2015047. (vi) Scott Koranda acknowledges support provided by the United States National Science Foundation under Grant No. PHY-1700765. (vii)GE ́ANTAssociationonbehalfoftheGN4Phase2project(GN4-2).Theresearchleadingtotheseresultshas received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 731122(GN4-2). (viii) ELIXIR acknowledges support from Research Infrastructure programme of Horizon 2020 grant No 676559 EXCELERATE. (ix) CORBEL life science cluster acknowledges support from Horizon 2020 research and innovation programme under grant agreement No 654248. (x) Mirjam van Daalen acknowledges that the research leading to this result has been supported by the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020. (xi) EISCAT is an international association supported by research organisations in China (CRIRP), Finland (SA), Japan (NIPR), Norway (NFR), Sweden (VR), and the United Kingdom (NERC). This white-paper expresses common requirements of Research Communities seeking to leverage Identity Federation for Authentication and Authorisation. Recommendations are made to Stakeholders to guide the future evolution of Federated Identity Management in a direction that better satisfies research use cases. The authors represent research communities, Research Services, Infrastructures, Identity Federations and Interfederations, with a joint motivation to ease collaboration for distributed researchers. The content has been edited collaboratively by the Federated Identity Management for Research (FIM4R) Community, with input sought at conferences and meetings in Europe, Asia and North America.

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