Final Probe Regions. Complete listing of all regions used in alignments to generate probes. (XLSX 1446Â kb)
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This dataset contains the raw, unprocessed immunofluorescence, live-cell imaging and Western blot data for the manuscript entitled: Interactome rewiring following pharmacological targeting of BET bromodomains. All methods employed to generate this dataset can be found in the accompanying manuscript and supplemental material.
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Supporting data and code for Wucherpfennig et al. Nature Ecology and Evolution. R codes, count matrices, phenotype files, and genotype files are organized by the figure in which they are used (with the exception of the QTL mapping files assign to Figure 1 that were also used for Extended Data Figures 1 and 2). Shell scripts used for allele-specific RNA-sequencing analysis are numbered in the order in which they were used. Raw sequencing data can be found on SRA and GEO. Other phenotype files are included in the source data of the paper on the NEE website.
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Simulation of a black-hole binary system evolved by the SpEC code.
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Simulation of a black-hole binary system evolved by the SpEC code.
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Additional file 2. Data of individual patients.
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Additional file 5. Quantitative synthesis database. This file provides the full narrative synthesis database, a database of all data sets that were excluded from quantitative synthesis, and individual databases for all global and intervention type analyses (i.e., for fish injury, immediate and delayed mortality).
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Simulation of a black-hole binary system evolved by the SpEC code.
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Simulation of a black-hole binary system evolved by the SpEC code.
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Abstract Background Feature-based attention prioritizes the processing of the attended feature while strongly suppressing the processing of nearby ones. This creates a non-linearity or “attentional suppressive surround” predicted by the Selective Tuning model of visual attention. However, previously reported effects of feature-based attention on neuronal responses are linear, e.g., feature-similarity gain. Here, we investigated this apparent contradiction by neurophysiological and psychophysical approaches. Results Responses of motion direction-selective neurons in area MT/MST of monkeys were recorded during a motion task. When attention was allocated to a stimulus moving in the neurons’ preferred direction, response tuning curves showed its minimum for directions 60–90° away from the preferred direction, an attentional suppressive surround. This effect was modeled via the interaction of two Gaussian fields representing excitatory narrowly tuned and inhibitory widely tuned inputs into a neuron, with feature-based attention predominantly increasing the gain of inhibitory inputs. We further showed using a motion repulsion paradigm in humans that feature-based attention produces a similar non-linearity on motion discrimination performance. Conclusions Our results link the gain modulation of neuronal inputs and tuning curves examined through the feature-similarity gain lens to the attentional impact on neural population responses predicted by the Selective Tuning model, providing a unified framework for the documented effects of feature-based attention on neuronal responses and behavior.
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Final Probe Regions. Complete listing of all regions used in alignments to generate probes. (XLSX 1446Â kb)
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This dataset contains the raw, unprocessed immunofluorescence, live-cell imaging and Western blot data for the manuscript entitled: Interactome rewiring following pharmacological targeting of BET bromodomains. All methods employed to generate this dataset can be found in the accompanying manuscript and supplemental material.
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