While, in recent years, scientists have gained ground on understanding the neurology of gambling behavior and the development of compulsion regarding these activities, there are still no effective treatments when dealing with these disorders. In 2013, the National Center for Responsible Gaming labeled Yale University a Center of Excellence in Gambling Research (Yale Gambling CORE) and funded the institution to study gambling disorders. The project sought to investigate these problems by applying interdisciplinary research integrating clinical, epidemiological, psychopharmacological, behavioral, prevention, genetic, and neuroimaging approaches. The team, led by Dr. Marc Potenza, professor of psychiatry, child study, and neurobiology, examined the emotional and motivational factors that impact the development of gambling disorders in women and men and the role of stress in fueling gambling urges. The project took advantage of an interactive approach, exploiting various resources at Yale University, including collaborations with external investigators, regional and national advocacy, treatment and prevention agencies, and the utilization of publicly available information. As referenced in this article regarding the neurology of pathological gamblers, to date, there is no FDA-approved treatment for gambling disorders. Placebo-controlled trials have investigated pharmacological and behavioral therapy, which have received empirical support as short-term treatment options. However, in separate randomized clinical trials, opioid antagonists (nalmefene and naltrexone) have proven superior. Thus, CORE investigators emphasized naltrexone, exploring its effectiveness in a clinical setting. Research has shown neural activity connected to most kinds of human addictions. The team also sought to test medications as possible treatment and to understand their effectiveness via neuroimaging technology. The goal was to discover if the problem is hardwired and if such wiring can get fixed. Understanding the neurology of this compulsion will undoubtedly lead to more successful future treatments. Below, what follows are Yale's Gambling CORE studies and papers related to gambling neurology. Materials, which have been debated at conferences and outreach events and disseminated through peer-reviewed publications.