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33 Research products

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Holstege, Henne; Grozeva, Detelina; Sims, Rebecca; Luckcuck, Lauren; +85 Authors

    The genetic component of Alzheimer’s disease (AD) has been mainly assessed using Genome Wide Association Studies (GWAS), which do not capture the risk contributed by rare variants. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals —16,036 AD cases and 16,522 controls— in a two-stage analysis. Next to known genes TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Next to these genes, the rare variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential driver genes in AD-GWAS loci. Rare damaging variants in these genes, and in particular loss-of-function variants, have a large effect on AD-risk, and they are enriched in early onset AD cases. The newly identified AD-associated genes provide additional evidence for a major role for APP-processing, Aβ-aggregation, lipid metabolism and microglial function in AD.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ CORE (RIOXX-UK Aggre...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ CORE (RIOXX-UK Aggre...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Wilcoxon, Anna;

    Limited information exists on the effects of self-reported exercise on subjective and objective measures of chemotherapy-induced peripheral neuropathy (CIPN). In this study, we evaluated for differences in demographic and clinical characteristics, as well as subjective and objective measures of CIPN and balance among 290 cancer survivors with CIPN who were classified into one of three exercise (Ex) groups (i.e., NoEx, LessEx, RecEX) based on the recommended level of >150 minutes per week. Survivors completed self-report questionnaires and underwent a sensory examination and balance testing. Compared to RecEx group (34.8%), survivors in the NoEx group (20.7%) had less education, were less likely to be married/partnered, had a lower household income, a higher level of comorbidity, and a poorer functional status. No differences were found among the three exercise groups in duration of CIPN, pain intensity scores, or changes in light touch, cold and pain sensations. However, compared to the RecEx group, survivors in the NoEx group had higher vibratory thresholds and worse scores on objective measures of balance. Based on our “real world” findings, clinicians can recommend walking as a therapeutic option, as well as referrals to physical therapy for additional balance and strength training in survivors with CIPN.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ eScholarship - Unive...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ eScholarship - Unive...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Zhang, Yuan-Wei; Uchendu, Stacey; Leone, Vanessa; Bradshaw, Richard T.; +3 Authors

    Data needed to generate the GlyT1 homology model presented in https://doi.org/10.1101/2020.08.20.259572 manuscript. do_model_1.py - MODELLER software script needed for the homology modeling glyt1_on_4xp4_noloop.pir - Alignment file used by the MODELLER software to generate the homology models template-lig.pdb - Structural file of the template (dDAT dopamine transporter) used by the MODELLER software to generate the homology models glyt1-model.pdb - Final GlyT1 model

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2020
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Other ORP type . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Hoffman, Mariah M.; Zylla, Jessica S.; Bhattacharya, Somshuvra; Calar, Kristin; +6 Authors

    Figure S1: Epigenetic regulators are overexpressed in ATRT relative to normal brain, Figure S2: 4SC-202 reduces growth of 3-dimensional ATRT-06 spheroids, Figure S3: Density plots of cell size from segmented confocal images of ATRT scaffold model, Figure S4: 4SC-202 significantly reduces HDAC1, HDAC2, and SMARCB1 gene expression, Figure S5: Stem cell markers are underexpressed in 4SC-202-treated spheroids and overexpressed in cluster 6, Figure S6: Highly differentially expressed genes are stable across comparisons, Figure S7: Enriched biological process network, Figure S8: Cerebellum protein-protein interaction (ppi) network, Figure S9: Gene-miRNA interaction network, Figure S10: Gene-transcription factor interaction network, Figure S11: Cerebellum gene co-expression network, Figure S12: Densely connected subregion (cluster) 1 and biological process enrichment from integrated systems biology analysis, Figure S13: Densely connected subregion (cluster) 2 and biological process enrichment from integrated systems biology analysis, Figure S14: Densely connected subregion (cluster) 3 and biological process enrichment from integrated systems biology analysis, Figure S15: Densely connected subregion (cluster) 4 and biological process enrichment from integrated systems biology analysis, Figure S16: Densely connected subregion (cluster) 5 and biological process enrichment from integrated systems biology analysis, Figure S17: Genes differentially expressed between 4SC-202-treated and control spheroids in both single-cell and bulk RNA-sequencing datasets are enriched for ribosome-related GO terms, Figure S18: Cropping location relative to the total intensity along the z-axis, Figure S19: Parameter selection plots for single cell analysis in Seurat, Figure S20: Seurat graph-based clusters correlate with clusters identified using the CellRanger pipeline, File S2: DAVID functional annotation clustering results for bulk sequencing, File S3: DAVID functional annotation clustering for single cell sequencing, [m1] [M2] Video S1: Cropped and thresholded confocal image stack from scaffold with no treatment 3 days after seeding, Video S2: Cropped and thresholded confocal image stack from scaffold treated with DMSO 3 days after seeding, Video S3: Cropped and thresholded confocal image stack from scaffold treated with 0.02 µM 4SC-202 3 days after seeding, Video S4: Cropped and thresholded confocal image stack from scaffold treated with 50 µM 4SC-202 3 days after seeding.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2020
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Other ORP type . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    The attached compressed file package supplements our research article. It comprises SARS-CoV-2 variant timemaps SVG files for 2020 and 2021, updated with data submitted to GISAID as of February 10th 2021 (inclusive). It is a snapshot of the webpage hosting these maps (https://bcgsc.github.io/SARS2) on that day and includes the script and single nucleotide variation (SNV) report files used to generate these and could be used by anyone to generate additional and custom interactive SVG maps. The frequently updated and comprehensive SARS-CoV-2 genome SNV reports (https://www.bcgsc.ca/downloads/btl/SARS-CoV-2/mutations) represent a wealth of variant information that could be mined to gain further insights into the rapid SARS-CoV-2 coronavirus evolution in human hosts.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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    ZENODO
    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Other ORP type . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • Authors: Kamml, Julia;
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    Authors: Martinez, Andres; Hua, Jason; Haque, Ezazul; Thorne, Peter; +1 Authors

    We report the results of polychlorinated biphenyls (PCBs) in the urban surficial soil of East Chicago, Indiana, USA, from thirty-three sites. PCB congeners were measured using tandem mass spectrometry (GC-MS/MS) in multiple reaction monitoring mode (MRM), a method that provides a high-level selectivity and sensitivity for PCBs in complex environmental samples. One hundred and seventy-one individual PCB congeners were detected and measured. The concentration of total PCB ranged from 20 to 1700 ng/g dry weight. Soil total organic carbon (TOC) was also measured using a Total Organic Carbon Analyzer and reported here. As QA/QC and using the same analytical method as for the soil samples, results from certified standard reference sediments (SRM 1944, National Institutes of Standards and testing) are also reported.

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    Authors: Sonia; Lisa; Helena;

    Introduction to the NIH Generalist Repository Ecosystem Initiative (GREI) including the program's mission, vision, objectives, goals in progress, and outcomes. Learn more at: https://datascience.nih.gov/data-ecosystem/generalist-repository-ecosystem-initiative

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Warren, Rene; Birol, Inanc;

    As year 2020 came to a close, several new strains have been reported for the SARS-CoV-2 coronavirus, the agent responsible for the COVID-19 pandemic that has afflicted us all this past year. However, it is difficult to comprehend the scale, in sequence space, geographical location and time, at which SARS-CoV-2 mutates and evolves in its human hosts. To get an appreciation for the rapid evolution of the coronavirus, we built interactive scalable vector graphics (SVG) maps that show daily nucleotide variations in genomes from the six most populated continents compared to that of the initial, ground-zero SARS-CoV-2 isolate sequenced at the beginning of the year. The attached compressed file package comprises SARS-CoV-2 mutation timemaps for 2020 and 2021, updated with data submitted to GISAID (gisaid.org) as of January 25th 2021 (inclusive). It is a snapshot of the webpage hosting these maps (https://bcgsc.github.io/SARS2) on that day.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ousdal, Olga Therese; Argyelan, Miklos; Narr, Katherine L.; Abbott, Christopher; +30 Authors

    Background Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. Methods Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. Results Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean ± SD of 1.04 ± 1.03% (Cohen’s d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 ± 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman’s rank correlation ρ = −.44, p < .001), while total white matter volume remained unchanged (d = −0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. Conclusions The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Holstege, Henne; Grozeva, Detelina; Sims, Rebecca; Luckcuck, Lauren; +85 Authors

    The genetic component of Alzheimer’s disease (AD) has been mainly assessed using Genome Wide Association Studies (GWAS), which do not capture the risk contributed by rare variants. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals —16,036 AD cases and 16,522 controls— in a two-stage analysis. Next to known genes TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Next to these genes, the rare variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential driver genes in AD-GWAS loci. Rare damaging variants in these genes, and in particular loss-of-function variants, have a large effect on AD-risk, and they are enriched in early onset AD cases. The newly identified AD-associated genes provide additional evidence for a major role for APP-processing, Aβ-aggregation, lipid metabolism and microglial function in AD.

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    Authors: Wilcoxon, Anna;

    Limited information exists on the effects of self-reported exercise on subjective and objective measures of chemotherapy-induced peripheral neuropathy (CIPN). In this study, we evaluated for differences in demographic and clinical characteristics, as well as subjective and objective measures of CIPN and balance among 290 cancer survivors with CIPN who were classified into one of three exercise (Ex) groups (i.e., NoEx, LessEx, RecEX) based on the recommended level of >150 minutes per week. Survivors completed self-report questionnaires and underwent a sensory examination and balance testing. Compared to RecEx group (34.8%), survivors in the NoEx group (20.7%) had less education, were less likely to be married/partnered, had a lower household income, a higher level of comorbidity, and a poorer functional status. No differences were found among the three exercise groups in duration of CIPN, pain intensity scores, or changes in light touch, cold and pain sensations. However, compared to the RecEx group, survivors in the NoEx group had higher vibratory thresholds and worse scores on objective measures of balance. Based on our “real world” findings, clinicians can recommend walking as a therapeutic option, as well as referrals to physical therapy for additional balance and strength training in survivors with CIPN.

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    Authors: Zhang, Yuan-Wei; Uchendu, Stacey; Leone, Vanessa; Bradshaw, Richard T.; +3 Authors

    Data needed to generate the GlyT1 homology model presented in https://doi.org/10.1101/2020.08.20.259572 manuscript. do_model_1.py - MODELLER software script needed for the homology modeling glyt1_on_4xp4_noloop.pir - Alignment file used by the MODELLER software to generate the homology models template-lig.pdb - Structural file of the template (dDAT dopamine transporter) used by the MODELLER software to generate the homology models glyt1-model.pdb - Final GlyT1 model

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Hoffman, Mariah M.; Zylla, Jessica S.; Bhattacharya, Somshuvra; Calar, Kristin; +6 Authors

    Figure S1: Epigenetic regulators are overexpressed in ATRT relative to normal brain, Figure S2: 4SC-202 reduces growth of 3-dimensional ATRT-06 spheroids, Figure S3: Density plots of cell size from segmented confocal images of ATRT scaffold model, Figure S4: 4SC-202 significantly reduces HDAC1, HDAC2, and SMARCB1 gene expression, Figure S5: Stem cell markers are underexpressed in 4SC-202-treated spheroids and overexpressed in cluster 6, Figure S6: Highly differentially expressed genes are stable across comparisons, Figure S7: Enriched biological process network, Figure S8: Cerebellum protein-protein interaction (ppi) network, Figure S9: Gene-miRNA interaction network, Figure S10: Gene-transcription factor interaction network, Figure S11: Cerebellum gene co-expression network, Figure S12: Densely connected subregion (cluster) 1 and biological process enrichment from integrated systems biology analysis, Figure S13: Densely connected subregion (cluster) 2 and biological process enrichment from integrated systems biology analysis, Figure S14: Densely connected subregion (cluster) 3 and biological process enrichment from integrated systems biology analysis, Figure S15: Densely connected subregion (cluster) 4 and biological process enrichment from integrated systems biology analysis, Figure S16: Densely connected subregion (cluster) 5 and biological process enrichment from integrated systems biology analysis, Figure S17: Genes differentially expressed between 4SC-202-treated and control spheroids in both single-cell and bulk RNA-sequencing datasets are enriched for ribosome-related GO terms, Figure S18: Cropping location relative to the total intensity along the z-axis, Figure S19: Parameter selection plots for single cell analysis in Seurat, Figure S20: Seurat graph-based clusters correlate with clusters identified using the CellRanger pipeline, File S2: DAVID functional annotation clustering results for bulk sequencing, File S3: DAVID functional annotation clustering for single cell sequencing, [m1] [M2] Video S1: Cropped and thresholded confocal image stack from scaffold with no treatment 3 days after seeding, Video S2: Cropped and thresholded confocal image stack from scaffold treated with DMSO 3 days after seeding, Video S3: Cropped and thresholded confocal image stack from scaffold treated with 0.02 µM 4SC-202 3 days after seeding, Video S4: Cropped and thresholded confocal image stack from scaffold treated with 50 µM 4SC-202 3 days after seeding.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Other ORP type . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    The attached compressed file package supplements our research article. It comprises SARS-CoV-2 variant timemaps SVG files for 2020 and 2021, updated with data submitted to GISAID as of February 10th 2021 (inclusive). It is a snapshot of the webpage hosting these maps (https://bcgsc.github.io/SARS2) on that day and includes the script and single nucleotide variation (SNV) report files used to generate these and could be used by anyone to generate additional and custom interactive SVG maps. The frequently updated and comprehensive SARS-CoV-2 genome SNV reports (https://www.bcgsc.ca/downloads/btl/SARS-CoV-2/mutations) represent a wealth of variant information that could be mined to gain further insights into the rapid SARS-CoV-2 coronavirus evolution in human hosts.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other ORP type . 2021
    License: CC BY
    Data sources: ZENODO
    image/svg+xml