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Figures, tables and captions from Chapter 3: Drivers of biodiversity change affecting biological invasions. In: Thematic Assessment Report on Invasive Alien Species and their Control of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services.

Singularity image with operational build for 3DSlicer, SlicerDMRI extensions, miniconda, and whitematteranalysis .py libs. (O'Donnell RG)

Data set from the article Moons P, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Ombelet F, Apers S, Kovacs AH; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD). Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries. Can J Cardiol. 2021 Feb;37(2):215-223. doi: 10.1016/j.cjca.2020.03.044. Epub 2020 Apr 6. PMID: 32739453. This is the abstract: Background: We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods: In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale, respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions: Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

This link contains the raw data of the article "Auditory White Noise Exposure Modulates Human Cortical Excitability Patterns", by Schuler et al. (2023).

Cet ensemble de donnée contient les données issues des entrevues que nous avons réalisé avec des spécialistes retrouvés dans le groupe Facebook de machines à écrire.

In order to identify candidate protein binding partners of the transcription factor HEB, we generated conditional HEBAlt-HA transgenic mice. The transgene consisted of an HA-tagged HEBAlt coding region inserted downstream of a ROSA26-loxP-stop-loxP sequence to enable Cre recombinase activated expression of the transgene. Mice with two transgenic alleles without Cre are termed "TT" whereas those bred onto the Vav-Cre background are termed "TTV". Whole thymocytes were obtained from TT (n=2) or TTV (n=2) mice and subjected to immunoprecipitation using an anti-HA antibody and magnetic beads. Samples were trypsin-digested and analyzed by mass spectrometry on a Q Exactive HF-X Mass Spectrometer by the SPARC BioCentre facility (SickKids, Toronto). Scaffold (version Scaffold_4.8.9, Proteome Software Inc., Portland, OR) was used to validate MS/MS based peptide and protein identifications. Protein probabilities were assigned by the Protein Prophet algorithm81.

SWATH-MS has become a mainstream method for quantitative proteomics, however consistent quantification across multiple LC-MS/MS instruments remains a bottleneck in parallelizing the data-acquisition. To produce a highly consistent and quantitatively accurate data matrix, we have developed DIAlignR which uses raw fragment-ion chromatograms for cross-run alignment. Its performance on a gold standard annotated dataset, demonstrates a threefold reduction in the identification error-rate when compared to standard non-aligned SWATH-MS results. A similar performance is achieved for a dataset of 229 runs acquired using 11 different LC-MS/MS setups. Finally, the analysis of 949 plasma runs with DIAlignR increased the number of statistically significant proteins by 43% and 62% for insulin resistant (IR) and respiratory viral infection (RVI), respectively compared to prior analysis without it. Hence, DIAlignR fills a gap in analyzing SWATH-MS runs acquired in-parallel using different LC-MS/MS instrumentation.

This dataset contains a group of global, half-degree, monthly climate covariates, and leaf area index records, for the period of 1982-2015.

Data set from the article Bernardini A, Camporeale A, Pieroni M, Pieruzzi F, Figliozzi S, Lusardi P, Spada M, Mignani R, Burlina A, Carubbi F, Battaglia Y, Graziani F, Pica S, Tondi L, Chow K, Boveri S, Olivotto I, Lombardi M. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy. JACC Cardiovasc Imaging. 2020 Oct;13(10):2262-2264. doi: 10.1016/j.jcmg.2020.05.011. Epub 2020 Jun 17. PMID: 32563647. Brief introduction Anderson-Fabry disease (AFD) cardiomyopathy is characterized by glycosphingolipid (Gb3) storage in all cellular components, with consequent left ventricular hypertrophy (LVH). Gb3 accumulation also involves atrial myocytes (1), ultimately leading to left atrial (LA) enlargement and reduced atrial compliance. Cardiac magnetic resonance (CMR) plays an important role in the assessment of the severity of Fabry cardiomyopathy. CMR feature tracking (CMR-FT) specifically allows the assessment of myocardial strain from cine images

The Nuclear Imaging Detector Development group at the Department of Physics, University of Regina is developing Canada's first positron emission tomography (PET) system for plant physiological function studies In its current configuration the system consists of four detectors heads, each with active area of 48x48 mm2 In a typical arrangement the four detectors are grouped in two pairs of opposing heads for detecting coincident events from positron annihilation, however the system geometry, data acquisition and image reconstruction are flexible and can be easily reconfigured on-demand to accommodate other scanner configurations The detector pairs can be scanned along the vertical axis allowing to image plants up to 50 cm tall, while the plant within the Field of View (FOV) of the scanner can be rotated on a precision controlled motorized platform to provide a complete 3D coverage of the plant Current development and characterization of the plant PET system will be presented.