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Data set from the article Moons P, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Ombelet F, Apers S, Kovacs AH; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD). Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries. Can J Cardiol. 2021 Feb;37(2):215-223. doi: 10.1016/j.cjca.2020.03.044. Epub 2020 Apr 6. PMID: 32739453. This is the abstract: Background: We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods: In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale, respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions: Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

Cet ensemble de donnée contient les données issues des entrevues que nous avons réalisé avec des spécialistes retrouvés dans le groupe Facebook de machines à écrire.

In order to identify candidate protein binding partners of the transcription factor HEB, we generated conditional HEBAlt-HA transgenic mice. The transgene consisted of an HA-tagged HEBAlt coding region inserted downstream of a ROSA26-loxP-stop-loxP sequence to enable Cre recombinase activated expression of the transgene. Mice with two transgenic alleles without Cre are termed "TT" whereas those bred onto the Vav-Cre background are termed "TTV". Whole thymocytes were obtained from TT (n=2) or TTV (n=2) mice and subjected to immunoprecipitation using an anti-HA antibody and magnetic beads. Samples were trypsin-digested and analyzed by mass spectrometry on a Q Exactive HF-X Mass Spectrometer by the SPARC BioCentre facility (SickKids, Toronto). Scaffold (version Scaffold_4.8.9, Proteome Software Inc., Portland, OR) was used to validate MS/MS based peptide and protein identifications. Protein probabilities were assigned by the Protein Prophet algorithm81.

Data set from the article Bernardini A, Camporeale A, Pieroni M, Pieruzzi F, Figliozzi S, Lusardi P, Spada M, Mignani R, Burlina A, Carubbi F, Battaglia Y, Graziani F, Pica S, Tondi L, Chow K, Boveri S, Olivotto I, Lombardi M. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy. JACC Cardiovasc Imaging. 2020 Oct;13(10):2262-2264. doi: 10.1016/j.jcmg.2020.05.011. Epub 2020 Jun 17. PMID: 32563647. Brief introduction Anderson-Fabry disease (AFD) cardiomyopathy is characterized by glycosphingolipid (Gb3) storage in all cellular components, with consequent left ventricular hypertrophy (LVH). Gb3 accumulation also involves atrial myocytes (1), ultimately leading to left atrial (LA) enlargement and reduced atrial compliance. Cardiac magnetic resonance (CMR) plays an important role in the assessment of the severity of Fabry cardiomyopathy. CMR feature tracking (CMR-FT) specifically allows the assessment of myocardial strain from cine images

Data set from the article Casteigt B, Samuel M, Laplante L, Shohoudi A, Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes Lpd SM, White K, Callus E, Kutty S, Brouillette J, Moons P, Khairy P; of the APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD). Atrial arrhythmias and patient-reported outcomes in adults with congenital heart disease: An international study. Heart Rhythm. 2020 Sep 19:S1547-5271(20)30894-8. doi: 10.1016/j.hrthm.2020.09.012. Epub ahead of print. PMID: 32961334. This is the abstract: Background: Atrial arrhythmias (ie, intra-atrial reentrant tachycardia and atrial fibrillation) are a leading cause of morbidity and hospitalization in adults with congenital heart disease (CHD). Little is known about their effect on quality of life and other patient-reported outcomes (PROs) in adults with CHD. Objective: The purpose of this study was to assess the impact of atrial arrhythmias on PROs in adults with CHD and explore geographic variations. Methods: Associations between atrial arrhythmias and PROs were assessed in a cross-sectional study of adults with CHD from 15 countries spanning 5 continents. A propensity-based matching weight analysis was performed to compare quality of life, perceived health status, psychological distress, sense of coherence, and illness perception in patients with and those without atrial arrhythmias. Results: A total of 4028 adults with CHD were enrolled, 707 (17.6%) of whom had atrial arrhythmias. After applying matching weights, patients with and those without atrial arrhythmias were comparable with regard to age (mean 40.1 vs 40.2 years), demographic variables (52.5% vs 52.2% women), and complexity of CHD (15.9% simple, 44.8% moderate, and 39.2% complex in both groups). Patients with atrial arrhythmias had significantly worse PRO scores with respect to quality of life, perceived health status, psychological distress (ie, depression), and illness perception. A summary score that combines all PRO measures was significantly lower in patients with atrial arrhythmias (-3.3%; P = .0006). Differences in PROs were consistent across geographic regions. Conclusion: Atrial arrhythmias in adults with CHD are associated with an adverse impact on a broad range of PROs consistently across various geographic regions.

NOTE: It's easier to download this dataset from pyrfume. Here's how: # First install pyrfume in your Python environment. This can be done easily with pip. # pip install pyrfume import pyrfume molecules = pyrfume.load_data('leffingwell/molecules.csv', remote=True) behavior = pyrfume.load_data('leffingwell/behavior.csv', remote=True) # e.g. to count the number of molecules with each descriptor behavior.sum().sort_values(ascending=False).astype(int) Predicting properties of molecules is an area of growing research in machine learning, particularly as models for learning from graph-valued inputs improve in sophistication and robustness. A molecular property prediction problem that has received comparatively little attention during this surge in research activity is building Structure-Odor Relationships (SOR) models (as opposed to Quantitative Structure-Activity Relationships, a term from medicinal chemistry). This is a 70+ year-old problem straddling chemistry, physics, neuroscience, and machine learning. To spur development on the SOR problem, we curated and cleaned a dataset of 3523 molecules associated with expert-labeled odor descriptors from the Leffingwell PMP 2001 database. We provide featurizations of all molecules in the dataset using bit-based and count-based fingerprints, Mordred molecular descriptors, and the embeddings from our trained GNN model (Sanchez-Lengeling et al., 2019). This dataset is comprised of two files: leffingwell_data.csv: this contains molecular structures, and what they smell like, along with train, test, and cross-validation splits. More detail on the file structure is found in leffingwell_readme.pdf. leffingwell_embeddings.npz: this contains several featurizations of the molecules in the dataset. leffingwell_readme.pdf: a more detailed description of the data and its provenance, including expected performance metrics. LICENSE: a copy of the CC-BY-NC license language. The dataset, and all associated features, is freely available for research use under the CC-BY-NC license. If you use the data in a publication, please cite: @article{sanchez2019machine, title={Machine learning for scent: Learning generalizable perceptual representations of small molecules}, author={Sanchez-Lengeling, Benjamin and Wei, Jennifer N and Lee, Brian K and Gerkin, Richard C and Aspuru-Guzik, Al{\'a}n and Wiltschko, Alexander B}, journal={arXiv preprint arXiv:1910.10685}, year={2019} } {"references": ["Sanchez-Lengeling et al. (2019). Machine Learning for Scent: Learning Generalizable Perceptual Representations of Small Molecules. arXiv:1910.10685"]}

The trajectories of Arctic cod (Boreogadus saida) caught in the Hudson Bay were modelled to their hatch locations. This is a data set of the salinity, temperature and coordinates of the hatch location predicted by the model as well as the salinity and coordinates of the catch location. The data set also includes the Strontium 88 concentration in the core and edge of the otoliths of a subset of the larvae.

Contains materials related to research on culture and viewpoint-dependent perception of facial expressions portrayed on masks used in the Japanese Noh Theatre. The archive includes the images used in the experiments as well as various documents related to the project. Animations animated gif of the antique Magojiro mask tilting forwards & back mp4 file with a comparison of new & old masks at different tilts Article pdf of article on the research project atr99.pdf contains a short summary of the project that may be helpful manuscript of the article (latex source files) correspondence with the publisher final versions of the article figures Composites composite figures of masks and human face at varying tilts Experimental Stimuli folders XA, XC, XH, XT only XA and XH were used for experiments reported in the article tilt angles range from -30 to 30 degrees in 5 degree steps XA: antique Magojiro mask from Edo period XC: Magojiro mask from the current era (1980s or 90s) XH: female human face, images rendered from 3D scan XT: Ko-omote mask made by an amateur carver (collection of MJL) Misc 'behind the scenes' photos view of the Noh stage at the Nara Shin Kokai Do in Nara Koen view of the camera and apparatus used to adjust the tilt angle shape images rendered from scans of the Ko-omote mask and human face view of the Magojiro mask from the current era (collection of the Komparu family) close up of mouth area of the Magojiro mask from the current era view of the antique Edo period Magojiro mask view of the reverse of the antique Magojiro mask showing inscriptions Thank you for your interest in the project. Michael Lyons, Ph.D. Professor of Image Arts and Science Ritsumeikan University Kyoto, Japan

Output files associated with molecular dynamics simulations of the alternative splice variant of Nav1.5

These datasets contain information for the the species occurrence, trait, and wetland site characteristics used in this manuscript.