Background: Cannabis is the most widely used illegal drug globally, with almost 200 million users in 2019. This use is associated with many negative health consequences and social problems, such as low school performance and other drug use. Cannabis use can be articularly harmful if it starts early, if it’s excessive or if it occurs associated with other forms of problematic behaviours. A lot of health behaviours, good or bad, emerge during adolescence and remain through the life course. Changing unhealthy behaviours in adolescence would significantly impact society, such as reducing the load of disease, injuries, and economic costs. The objective of this study is to explore cannabis consumption profiles and the factors related to it during adolescence. Methods: This study is based on the 2017/2018 Health Behaviour in School-aged Children Luxembourg survey. Participated 6 880 adolescents, aged 12 to 18-year-old, that attended schools in Luxembourg that teach according to the national. Adolescents answered if they used cannabis during their lifetime and during the past month. Following, they were categorized into 4 groups: 1. never consumed cannabis in a lifetime; 2. consumed in a lifetime but not in the past month; 3. non-daily use during the past month and; 4. daily use (or almost) during the past month. To compare and characterize the groups, descriptive and bivariate analyzes were undertaken, as well as their significance level. Results: Results show that most of the adolescents (81.8%) never consumed cannabis in their lifetime; 9.4% declared a consumption during their lifetime but not the past month; 6.6% used during the past month, non-daily; and 2.2% used (almost) daily during the past month. Different profiles emerge between the groups, particularly with regard to socio-demographic characteristics and risky behaviours. In the case of social relationships and indicators of health and well-being, differences exist but are not as pronounced. Boys, older students and those who do not live with both parents are more likely to be part of groups that have used cannabis. In addition, most risk behaviours show a dose-response relationship with cannabis use. The increase in risky behaviours translates into not only a greater likelihood of using cannabis but also a greater frequency of use. Conclusion: The four different profiles evolve gradually with the frequency of cannabis consumption. This dose-effect relationship has been highlighted between cannabis consumption and the other variables present but is especially true for risk behaviours. Prevention strategies should distinguish adolescents from each of these groups, starting in early adolescence and focus on risk behaviours as a whole.