1,564 Research products, page 1 of 157
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- Publication . Article . 2022Open AccessAuthors:Jonatan Abraham; Vania Ceccato;Jonatan Abraham; Vania Ceccato;Publisher: Elsevier BVCountry: Sweden
This article explores the nature and frequency of crimes and people's safety perceptions in rural areas using a systematic review of the literature. It explores four decades of English-language publications on crime and safety in rural areas from several major databases; mainly Scopus, JSTOR and ScienceDirect. The number of retrieved documents was 840, of which 410 were selected for in-depth analysis and their topics later categorized by theme. We found that rural crime research took off after the mid-1980s and experienced an increase during the 2010s. Despite the domination by North American, British and Australian scholarship, studies from other parts of the world (including the Global South) are increasingly being published as well. Publications on rural crime patterns (e.g., farm crime) compose over one-fifth of the reviewed literature. This together with rural policing/criminal justice and violence constitute the three largest themes in rural criminology research. With ever-increasing links between the local and the global, this review article advocates for tailored multilevel responses to rural crimes that, more than ever, are generated by processes far beyond their localities. QC 20220926
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Software Paper . 2019Open Access EnglishAuthors:Pierre Augier; Ashwin Vishnu Mohanan; Cyrille Bonamy;Pierre Augier; Ashwin Vishnu Mohanan; Cyrille Bonamy;
doi: 10.5334/jors.237
Publisher: HAL CCSDCountries: France, SwedenProject: EC | WATU (647018)FluidDyn is a project to foster open-science and open-source in the fluid dynamics community. It is thought of as a research project to channel open-source dynamics, methods and tools to do science. We propose a set of Python packages forming a framework to study fluid dynamics with different methods, in particular laboratory experiments (package fluidlab), simulations (packages fluidfft, fluidsim and fluidfoam) and data processing (package fluidimage). In the present article, we give an overview of the specialized packages of the project and then focus on the base package called fluiddyn, which contains common code used in the specialized packages. Packages fluidfft and fluidsim are described with greater detail in two companion papers [4, 5]. With the project FluidDyn, we demonstrate that specialized scientific code can be written with methods and good practices of the open-source community. The Mercurial repositories are available in Bitbucket (https://bitbucket.org/fluiddyn/). All codes are documented using Sphinx and Read the Docs, and tested with continuous integration run on Bitbucket Pipelines and Travis. To improve the reuse potential, the codes are as modular as possible, leveraging the simple object-oriented programming model of Python. All codes are also written to be highly efficient, using C++, Cython and Pythran to speedup the performance of critical functions. Funding statement: This project has indirectly benefited from funding from the foundation Simone et Cino Del Duca de l’Institut de France, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 647018-WATU and Euhit consortium) and the Swedish Research Council (Vetenskapsrådet): 2013-5191. We have also been able to use supercomputers of CIMENT/GRICAD, CINES/GENCI (grant 2018-A0040107567) and the Swedish National Infrastructure for Computing (SNIC).
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2019Open Access SwedishAuthors:Sandström, Ulf;Sandström, Ulf;Publisher: KTH, Skolan för industriell teknik och management (ITM)Country: Sweden
QC 20220426
- Publication . Article . Conference object . Preprint . 2021Open AccessAuthors:Moa Yveborg; Cheng Xu; Erik Fredenberg; Mats Danielsson;Moa Yveborg; Cheng Xu; Erik Fredenberg; Mats Danielsson;Publisher: SPIECountry: Sweden
X-ray detectors made of crystalline silicon have several advantages including low dark currents, fast charge collection and high energy resolution. For high-energy x-rays, however, silicon suffers from its low atomic number, which might result in low detection efficiency, as well as low energy and spatial resolution due to Compton scattering. We have used a monte-carlo model to investigate the feasibility of a detector for pediatric CT with 30 to 40 mm of silicon using x-ray spectra ranging from 80 to 140 kVp. A detection efficiency of 0.74 was found at 80 kVp, provided the noise threshold could be set low. Scattered photons were efficiently blocked by a thin metal shielding between the detector units, and Compton scattering in the detector could be well separated from photo absorption at 80 kVp. Hence, the detector is feasible at low acceleration voltages, which is also suitable for pediatric imaging. We conclude that silicon detectors may be an alternative to other designs for this special case. QC 20120214
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Conference object . 2021Open Access EnglishAuthors:Giaretta, Lodovico; Savvidis, Ioannis; Marchioro, Thomas; Girdzijauskas, Sarunas; Pallis, George; Dikaiakos, Marios D.; Markatos, Evangelos;Giaretta, Lodovico; Savvidis, Ioannis; Marchioro, Thomas; Girdzijauskas, Sarunas; Pallis, George; Dikaiakos, Marios D.; Markatos, Evangelos;Publisher: KTH, Programvaruteknik och datorsystem, SCSCountry: SwedenProject: EC | RAIS (813162)
We envision PDS2, a decentralized data marketplace in which consumers submit their tasks to be run within the platform, on the data of willing providers. The goal of PDS2is to ensure that users maintain full control on their data and do not compromise their privacy, while being rewarded for the value that their data generates. In order to achieve this, our marketplace architecture employs blockchain technology, privacy-preserving computation and decentralized machine learning. We then compare different potential solutions and identify the Ethereum blockchain, trusted execution environments and gossip learning as the most suitable for the implementation of PDS2. We also discuss the main open challenges that are left to tackle and possible directions for future work.
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Preprint . 2019 . Embargo End Date: 01 Jan 2018Open AccessAuthors:Peter Göransson; Jacques Cuenca; Timo Lähivaara;Peter Göransson; Jacques Cuenca; Timo Lähivaara;Publisher: arXivCountry: Sweden
This paper studies the problem of parameter estimation in resonant, acoustic fluid-structure interaction problems over a wide frequency range. Problems with multiple resonances are known to be subjected to local minima, which represents a major challenge in the field of parameter identification. We propose a stepwise approach consisting in subdividing the frequency spectrum such that the solution to a low-frequency subproblem serves as the starting point for the immediately higher frequency range. In the current work, two different inversion frameworks are used. The first approach is a gradient-based deterministic procedure that seeks the model parameters by minimising a cost function in the least squares sense and the second approach is a Bayesian inversion framework. The latter provides a potential way to assess the validity of the least squares estimate. In addition, it presents several advantages by providing invaluable information on the uncertainty and correlation between the estimated parameters. The methodology is illustrated on synthetic measurements with known design variables and controlled noise levels. The model problem is deliberately kept simple to allow for extensive numerical experiments to be conducted in order to investigate the nature of the local minima in full spectrum analyses and to assess the potential of the proposed method to overcome these. Numerical experiments suggest that the proposed methods may present an efficient approach to find material parameters and their uncertainty estimates with acceptable accuracy. QC 20190228
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2021Open AccessAuthors:Isabelle Matthiesen; Dimitrios Voulgaris; Polyxeni Nikolakopoulou; Thomas E. Winkler; Anna Herland;Isabelle Matthiesen; Dimitrios Voulgaris; Polyxeni Nikolakopoulou; Thomas E. Winkler; Anna Herland;
pmid: 34174140
Country: SwedenProject: EC | NeuroVU (797777)Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with the goal of providing more human-like models for biopharmaceutical research. In this study, the first such model of the blood-brain barrier (BBB-on-chip) featuring both isogenic human induced pluripotent stem cell (hiPSC)-derived cells and continuous barrier integrity monitoring with <2 min temporal resolution is reported. Its capabilities are showcased in the first microphysiological study of nitrosative stress and antioxidant prophylaxis. Relying on off-stoichiometry thiol–ene–epoxy (OSTE+) for fabrication greatly facilitates assembly and sensor integration compared to the prevalent polydimethylsiloxane devices. The integrated cell–substrate endothelial resistance monitoring allows for capturing the formation and breakdown of the BBB model, which consists of cocultured hiPSC-derived endothelial-like and astrocyte-like cells. Clear cellular disruption is observed when exposing the BBB-on-chip to the nitrosative stressor linsidomine, and the barrier permeability and barrier-protective effects of the antioxidant N-acetylcysteine amide are reported. Using metabolomic network analysis reveals further drug-induced changes consistent with prior literature regarding, e.g., cysteine and glutathione involvement. A model like this opens new possibilities for drug screening studies and personalized medicine, relying solely on isogenic human-derived cells and providing high-resolution temporal readouts that can help in pharmacodynamic studies. QC 20220330
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2019Open Access EnglishAuthors:Fumi Harahap; Sylvain Leduc; Sennai Mesfun; Dilip Khatiwada; Florian Kraxner; Semida Silveira;Fumi Harahap; Sylvain Leduc; Sennai Mesfun; Dilip Khatiwada; Florian Kraxner; Semida Silveira;
doi: 10.3390/en12030420
Publisher: Molecular Diversity Preservation International (MDPI)Countries: Austria, SwedenSignificant amounts of biomass residues were generated in Indonesia. While untreated, residues emit greenhouse gases during the decomposition process. On the other hand, if efficiently utilized, these residues could be used to produce value-added products. This study investigates opportunities for harnessing the full potential of palm oil residues (i.e., empty fruit bunches, kernel shells, fiber, and mill effluent). As far as we are aware, the study is the first attempt to model the palm oil supply chain in a geographically explicit way while considering regional infrastructures in Sumatra Island, Indonesia. The BeWhere model, a mixed integer linear programming model for energy system optimization, was used to assess the costs and benefits of optimizing the regional palm oil supply chain. Different scenarios were investigated, considering current policies and new practices leading to improved yields in small-scale plantations and power grid connectivity. The study shows that a more efficient palm oil supply chain can pave the way for the country to meet up to 50% of its national bioenergy targets by 2025, and emission reductions of up to 40 MtCO2eq/year. As much as 50% of the electricity demand in Sumatra could be met if residues are efficiently used and grid connections are available. We recommend that system improvements be done in stages. In the short to medium term, improving the smallholder plantation yield is the most optimal way to maximize regional economic gains from the palm oil industry. In the medium to long term, improving electricity grid connection to palm oil mills could bring higher economic value as excess electricity is commercialized. QC 20190130
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Conference object . 2020Open AccessAuthors:Alfaras, Miquel; Tsaknaki, Vasiliki; Sanches, Pedro; Windlin, Charles; Umair, Muhammad; Sas, Corina; Höök, Kristina;Alfaras, Miquel; Tsaknaki, Vasiliki; Sanches, Pedro; Windlin, Charles; Umair, Muhammad; Sas, Corina; Höök, Kristina;
handle: 10234/189665
Publisher: ACMCountries: Sweden, SpainBiosensing technologies are increasingly available as off-the-shelf products, yet for many designers, artists and non-engineers, these technologies remain difficult to design with. Through a soma design stance, we devised a novel approach for exploring qualities in biodata. Our explorative process culminated in the design of three artefacts, coupling biosignals to tangible actuation formats. By making biodata perceivable as sound, in tangible form or directly on the skin, it became possible to link qualities of the measurements to our own somatics - our felt experience of our bodily bioprocesses - as they dynamically unfold, spurring somatically-grounded design discoveries of novel possible interactions. We show that making biodata attainable for a felt experience - or as we frame it: turning biodata into somadata - enables not only first-person encounters, but also supports collaborative design processes as the somadata can be shared and experienced dynamically, right at the moment when we explore design ideas. QC 20201021 AffecTech: Personal Technologies for Affective Health, Innovative Training Net- work funded by the H2020 People Programme under Marie Skłodowska Curie grant agreement No 722022 Swedish Foundation for Strategic Research project RIT15-0046 Swedish Research council project 2016-04709
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Preprint . Article . 2020Open Access EnglishAuthors:Ghadikolaei, Hossein; Ghauch, Hadi; Fodor, Gabor; Skoglund, Mikael; Fischione, Carlo;Ghadikolaei, Hossein; Ghauch, Hadi; Fodor, Gabor; Skoglund, Mikael; Fischione, Carlo;Publisher: KTH, Nätverk och systemteknikCountries: Sweden, France
Inter-operator spectrum sharing in millimeter-wave bands has the potential of substantially increasing the spectrum utilization and providing a larger bandwidth to individual user equipment at the expense of increasing inter-operator interference. Unfortunately, traditional model-based spectrum sharing schemes make idealistic assumptions about inter-operator coordination mechanisms in terms of latency and protocol overhead, while being sensitive to missing channel state information. In this paper, we propose hybrid model-based and data-driven multi-operator spectrum sharing mechanisms, which incorporate model-based beamforming and user association complemented by data-driven model refinements. Our solution has the same computational complexity as a model-based approach but has the major advantage of having substantially less signaling overhead. We discuss how limited channel state information and quantized codebook-based beamforming affect the learning and the spectrum sharing performance. We show that the proposed hybrid sharing scheme significantly improves spectrum utilization under realistic assumptions on inter-operator coordination and channel state information acquisition.
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.
1,564 Research products, page 1 of 157
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- Publication . Article . 2022Open AccessAuthors:Jonatan Abraham; Vania Ceccato;Jonatan Abraham; Vania Ceccato;Publisher: Elsevier BVCountry: Sweden
This article explores the nature and frequency of crimes and people's safety perceptions in rural areas using a systematic review of the literature. It explores four decades of English-language publications on crime and safety in rural areas from several major databases; mainly Scopus, JSTOR and ScienceDirect. The number of retrieved documents was 840, of which 410 were selected for in-depth analysis and their topics later categorized by theme. We found that rural crime research took off after the mid-1980s and experienced an increase during the 2010s. Despite the domination by North American, British and Australian scholarship, studies from other parts of the world (including the Global South) are increasingly being published as well. Publications on rural crime patterns (e.g., farm crime) compose over one-fifth of the reviewed literature. This together with rural policing/criminal justice and violence constitute the three largest themes in rural criminology research. With ever-increasing links between the local and the global, this review article advocates for tailored multilevel responses to rural crimes that, more than ever, are generated by processes far beyond their localities. QC 20220926
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Software Paper . 2019Open Access EnglishAuthors:Pierre Augier; Ashwin Vishnu Mohanan; Cyrille Bonamy;Pierre Augier; Ashwin Vishnu Mohanan; Cyrille Bonamy;
doi: 10.5334/jors.237
Publisher: HAL CCSDCountries: France, SwedenProject: EC | WATU (647018)FluidDyn is a project to foster open-science and open-source in the fluid dynamics community. It is thought of as a research project to channel open-source dynamics, methods and tools to do science. We propose a set of Python packages forming a framework to study fluid dynamics with different methods, in particular laboratory experiments (package fluidlab), simulations (packages fluidfft, fluidsim and fluidfoam) and data processing (package fluidimage). In the present article, we give an overview of the specialized packages of the project and then focus on the base package called fluiddyn, which contains common code used in the specialized packages. Packages fluidfft and fluidsim are described with greater detail in two companion papers [4, 5]. With the project FluidDyn, we demonstrate that specialized scientific code can be written with methods and good practices of the open-source community. The Mercurial repositories are available in Bitbucket (https://bitbucket.org/fluiddyn/). All codes are documented using Sphinx and Read the Docs, and tested with continuous integration run on Bitbucket Pipelines and Travis. To improve the reuse potential, the codes are as modular as possible, leveraging the simple object-oriented programming model of Python. All codes are also written to be highly efficient, using C++, Cython and Pythran to speedup the performance of critical functions. Funding statement: This project has indirectly benefited from funding from the foundation Simone et Cino Del Duca de l’Institut de France, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 647018-WATU and Euhit consortium) and the Swedish Research Council (Vetenskapsrådet): 2013-5191. We have also been able to use supercomputers of CIMENT/GRICAD, CINES/GENCI (grant 2018-A0040107567) and the Swedish National Infrastructure for Computing (SNIC).
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2019Open Access SwedishAuthors:Sandström, Ulf;Sandström, Ulf;Publisher: KTH, Skolan för industriell teknik och management (ITM)Country: Sweden
QC 20220426
- Publication . Article . Conference object . Preprint . 2021Open AccessAuthors:Moa Yveborg; Cheng Xu; Erik Fredenberg; Mats Danielsson;Moa Yveborg; Cheng Xu; Erik Fredenberg; Mats Danielsson;Publisher: SPIECountry: Sweden
X-ray detectors made of crystalline silicon have several advantages including low dark currents, fast charge collection and high energy resolution. For high-energy x-rays, however, silicon suffers from its low atomic number, which might result in low detection efficiency, as well as low energy and spatial resolution due to Compton scattering. We have used a monte-carlo model to investigate the feasibility of a detector for pediatric CT with 30 to 40 mm of silicon using x-ray spectra ranging from 80 to 140 kVp. A detection efficiency of 0.74 was found at 80 kVp, provided the noise threshold could be set low. Scattered photons were efficiently blocked by a thin metal shielding between the detector units, and Compton scattering in the detector could be well separated from photo absorption at 80 kVp. Hence, the detector is feasible at low acceleration voltages, which is also suitable for pediatric imaging. We conclude that silicon detectors may be an alternative to other designs for this special case. QC 20120214
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Conference object . 2021Open Access EnglishAuthors:Giaretta, Lodovico; Savvidis, Ioannis; Marchioro, Thomas; Girdzijauskas, Sarunas; Pallis, George; Dikaiakos, Marios D.; Markatos, Evangelos;Giaretta, Lodovico; Savvidis, Ioannis; Marchioro, Thomas; Girdzijauskas, Sarunas; Pallis, George; Dikaiakos, Marios D.; Markatos, Evangelos;Publisher: KTH, Programvaruteknik och datorsystem, SCSCountry: SwedenProject: EC | RAIS (813162)
We envision PDS2, a decentralized data marketplace in which consumers submit their tasks to be run within the platform, on the data of willing providers. The goal of PDS2is to ensure that users maintain full control on their data and do not compromise their privacy, while being rewarded for the value that their data generates. In order to achieve this, our marketplace architecture employs blockchain technology, privacy-preserving computation and decentralized machine learning. We then compare different potential solutions and identify the Ethereum blockchain, trusted execution environments and gossip learning as the most suitable for the implementation of PDS2. We also discuss the main open challenges that are left to tackle and possible directions for future work.
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Preprint . 2019 . Embargo End Date: 01 Jan 2018Open AccessAuthors:Peter Göransson; Jacques Cuenca; Timo Lähivaara;Peter Göransson; Jacques Cuenca; Timo Lähivaara;Publisher: arXivCountry: Sweden
This paper studies the problem of parameter estimation in resonant, acoustic fluid-structure interaction problems over a wide frequency range. Problems with multiple resonances are known to be subjected to local minima, which represents a major challenge in the field of parameter identification. We propose a stepwise approach consisting in subdividing the frequency spectrum such that the solution to a low-frequency subproblem serves as the starting point for the immediately higher frequency range. In the current work, two different inversion frameworks are used. The first approach is a gradient-based deterministic procedure that seeks the model parameters by minimising a cost function in the least squares sense and the second approach is a Bayesian inversion framework. The latter provides a potential way to assess the validity of the least squares estimate. In addition, it presents several advantages by providing invaluable information on the uncertainty and correlation between the estimated parameters. The methodology is illustrated on synthetic measurements with known design variables and controlled noise levels. The model problem is deliberately kept simple to allow for extensive numerical experiments to be conducted in order to investigate the nature of the local minima in full spectrum analyses and to assess the potential of the proposed method to overcome these. Numerical experiments suggest that the proposed methods may present an efficient approach to find material parameters and their uncertainty estimates with acceptable accuracy. QC 20190228
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2021Open AccessAuthors:Isabelle Matthiesen; Dimitrios Voulgaris; Polyxeni Nikolakopoulou; Thomas E. Winkler; Anna Herland;Isabelle Matthiesen; Dimitrios Voulgaris; Polyxeni Nikolakopoulou; Thomas E. Winkler; Anna Herland;
pmid: 34174140
Country: SwedenProject: EC | NeuroVU (797777)Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with the goal of providing more human-like models for biopharmaceutical research. In this study, the first such model of the blood-brain barrier (BBB-on-chip) featuring both isogenic human induced pluripotent stem cell (hiPSC)-derived cells and continuous barrier integrity monitoring with <2 min temporal resolution is reported. Its capabilities are showcased in the first microphysiological study of nitrosative stress and antioxidant prophylaxis. Relying on off-stoichiometry thiol–ene–epoxy (OSTE+) for fabrication greatly facilitates assembly and sensor integration compared to the prevalent polydimethylsiloxane devices. The integrated cell–substrate endothelial resistance monitoring allows for capturing the formation and breakdown of the BBB model, which consists of cocultured hiPSC-derived endothelial-like and astrocyte-like cells. Clear cellular disruption is observed when exposing the BBB-on-chip to the nitrosative stressor linsidomine, and the barrier permeability and barrier-protective effects of the antioxidant N-acetylcysteine amide are reported. Using metabolomic network analysis reveals further drug-induced changes consistent with prior literature regarding, e.g., cysteine and glutathione involvement. A model like this opens new possibilities for drug screening studies and personalized medicine, relying solely on isogenic human-derived cells and providing high-resolution temporal readouts that can help in pharmacodynamic studies. QC 20220330
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2019Open Access EnglishAuthors:Fumi Harahap; Sylvain Leduc; Sennai Mesfun; Dilip Khatiwada; Florian Kraxner; Semida Silveira;Fumi Harahap; Sylvain Leduc; Sennai Mesfun; Dilip Khatiwada; Florian Kraxner; Semida Silveira;
doi: 10.3390/en12030420
Publisher: Molecular Diversity Preservation International (MDPI)Countries: Austria, SwedenSignificant amounts of biomass residues were generated in Indonesia. While untreated, residues emit greenhouse gases during the decomposition process. On the other hand, if efficiently utilized, these residues could be used to produce value-added products. This study investigates opportunities for harnessing the full potential of palm oil residues (i.e., empty fruit bunches, kernel shells, fiber, and mill effluent). As far as we are aware, the study is the first attempt to model the palm oil supply chain in a geographically explicit way while considering regional infrastructures in Sumatra Island, Indonesia. The BeWhere model, a mixed integer linear programming model for energy system optimization, was used to assess the costs and benefits of optimizing the regional palm oil supply chain. Different scenarios were investigated, considering current policies and new practices leading to improved yields in small-scale plantations and power grid connectivity. The study shows that a more efficient palm oil supply chain can pave the way for the country to meet up to 50% of its national bioenergy targets by 2025, and emission reductions of up to 40 MtCO2eq/year. As much as 50% of the electricity demand in Sumatra could be met if residues are efficiently used and grid connections are available. We recommend that system improvements be done in stages. In the short to medium term, improving the smallholder plantation yield is the most optimal way to maximize regional economic gains from the palm oil industry. In the medium to long term, improving electricity grid connection to palm oil mills could bring higher economic value as excess electricity is commercialized. QC 20190130
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Conference object . 2020Open AccessAuthors:Alfaras, Miquel; Tsaknaki, Vasiliki; Sanches, Pedro; Windlin, Charles; Umair, Muhammad; Sas, Corina; Höök, Kristina;Alfaras, Miquel; Tsaknaki, Vasiliki; Sanches, Pedro; Windlin, Charles; Umair, Muhammad; Sas, Corina; Höök, Kristina;
handle: 10234/189665
Publisher: ACMCountries: Sweden, SpainBiosensing technologies are increasingly available as off-the-shelf products, yet for many designers, artists and non-engineers, these technologies remain difficult to design with. Through a soma design stance, we devised a novel approach for exploring qualities in biodata. Our explorative process culminated in the design of three artefacts, coupling biosignals to tangible actuation formats. By making biodata perceivable as sound, in tangible form or directly on the skin, it became possible to link qualities of the measurements to our own somatics - our felt experience of our bodily bioprocesses - as they dynamically unfold, spurring somatically-grounded design discoveries of novel possible interactions. We show that making biodata attainable for a felt experience - or as we frame it: turning biodata into somadata - enables not only first-person encounters, but also supports collaborative design processes as the somadata can be shared and experienced dynamically, right at the moment when we explore design ideas. QC 20201021 AffecTech: Personal Technologies for Affective Health, Innovative Training Net- work funded by the H2020 People Programme under Marie Skłodowska Curie grant agreement No 722022 Swedish Foundation for Strategic Research project RIT15-0046 Swedish Research council project 2016-04709
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Preprint . Article . 2020Open Access EnglishAuthors:Ghadikolaei, Hossein; Ghauch, Hadi; Fodor, Gabor; Skoglund, Mikael; Fischione, Carlo;Ghadikolaei, Hossein; Ghauch, Hadi; Fodor, Gabor; Skoglund, Mikael; Fischione, Carlo;Publisher: KTH, Nätverk och systemteknikCountries: Sweden, France
Inter-operator spectrum sharing in millimeter-wave bands has the potential of substantially increasing the spectrum utilization and providing a larger bandwidth to individual user equipment at the expense of increasing inter-operator interference. Unfortunately, traditional model-based spectrum sharing schemes make idealistic assumptions about inter-operator coordination mechanisms in terms of latency and protocol overhead, while being sensitive to missing channel state information. In this paper, we propose hybrid model-based and data-driven multi-operator spectrum sharing mechanisms, which incorporate model-based beamforming and user association complemented by data-driven model refinements. Our solution has the same computational complexity as a model-based approach but has the major advantage of having substantially less signaling overhead. We discuss how limited channel state information and quantized codebook-based beamforming affect the learning and the spectrum sharing performance. We show that the proposed hybrid sharing scheme significantly improves spectrum utilization under realistic assumptions on inter-operator coordination and channel state information acquisition.
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.