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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kempf, S. J.; Janik, Dirk; Barjaktarovic, Zarko; Braga-Tanaka III, I.; +5 Authors

    Accruing data indicate that radiation-induced consequences resemble pathologies of neurodegenerative diseases such as Alzheimer's. The aim of this study was to elucidate the effect on hippocampus of chronic low-dose-rate radiation exposure (1 mGy/day or 20 mGy/day) given over 300 days with cumulative doses of 0.3 Gy and 6.0 Gy, respectively. ApoE deficient mutant C57Bl/6 mouse was used as an Alzheimer's model. Using mass spectrometry, a marked alteration in the phosphoproteome was found at both dose rates. The radiation-induced changes in the phosphoproteome were associated with the control of synaptic plasticity, calcium-dependent signalling and brain metabolism. An inhibition of CREB signalling was found at both dose rates whereas Rac1-Cofilin signalling was found activated only at the lower dose rate. Similarly, the reduction in the number of activated microglia in the molecular layer of hippocampus that paralleled with reduced levels of TNFα expression and lipid peroxidation was significant only at the lower dose rate. Adult neurogenesis, investigated by Ki67, GFAP and NeuN staining, and cell death (activated caspase-3) were not influenced at any dose or dose rate. This study shows that several molecular targets induced by chronic low-dose-rate radiation overlap with those of Alzheimer's pathology. It may suggest that ionising radiation functions as a contributing risk factor to this neurodegenerative disease.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Oncotarget
    Article
    License: CC BY
    Data sources: UnpayWall
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ENEA Open Archive
    Article . 2016
    Data sources: ENEA Open Archive
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Oncotarget; ENEA Open Archive
    Article . Other ORP type . 2016 . Peer-reviewed
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ENEA Open Archive
    Article . 2016
    Data sources: ENEA Open Archive
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ENEA Open Archive
      Article . 2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Oncotarget; ENEA Open Archive
      Article . Other ORP type . 2016 . Peer-reviewed
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Grønvold, Mogens; Christensen, Caroline Arnfeldt; Johnsen, Anna Thit;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Ellegaard, Pernille Kempel;

    Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Heyn Sørensen, Martin;

    Patienter med type 2-diabetes har en øget risiko for at udvikle hjertesvigt uafhængigt af andre risikofaktorer, såsom arteriosklerose og hypertension. Denne øgede forekomst af hjertesvigt hos patienter med type 2-diabetes har ført til hypotesen om, at der findes en specifik diabetisk kardiomyopati, kendetegnet ved koncentrisk myokardiehypertrofi og diastolisk dysfunktion. Ændringer i hjertets mikrocirkulation og mikrovaskulær dysfunktion i hjertets små kar spiller muligvis en rolle i udviklingen af diabetisk kardiomyopati og hjertesvigt hos patienter med type 2-diabetes, men den nøjagtige mekanisme for, hvordan type 2-diabetes kan forårsage hjertesvigt uafhængigt af andre kardiovaskulære risikofaktorer er fortsat ukendt.I denne ph.d.-afhandling undersøgte vi, hvordan forskelle i den diabetiske fænotype (diabetiske komplikationer, risikofaktorer, anti-diabetesbehandling osv.) påvirker perfusion i myokardiet, som et mål for kardiel mikrovaskulær sygdom, og om ændringer i hjertestruktur og funktion hos patienter med type 2-diabetes er relateret til kardiel mikrovaskulær sygdom, som en mulig mekanisme bag udviklingen af diabetisk kardiomyopati.For at undersøge dette blev 273 patienter med type 2-diabetes og 25 kontrolpersoner uden type 2-diabetes inkluderet i en tværsnitsundersøgelse. Alle deltagere gennemgik klinisk undersøgelse, blodog urinprøveudtagning, ekkokardiografi og avanceret magnetisk resonans scanning af hjertet, inklusive sekvenser for vævskarakterisering og fuld kvantitativ myokardie perfusion i hvile og under farmakologisk stress (adenosin 140 ug/kg/min). Blod- og urinprøver fra alle patienter med type 2-diabetes blev opsamlet og transporteret til Region Sjællands biobank for langtidsopbevaring.Vi fandt, at patienter med type 2-diabetes havde lavere myokardie perfusions reserve sammenlignet med kontrolpersoner, og at denne reduktion i myokardie perfusions reserve var forårsaget af både en Martin Heyn Sørensen, 2020 5 stigning i myokardie perfusion i hvile og reduceret maksimal myokardie perfusion under farmakologisk stress. Patienter med type 2-diabetes kompliceret med albuminuri eller retinopati havde lavere myokardie perfusions reserve og lavere maksimal myokardie perfusion under farmakologisk stress, sammenlignet med patienter med ukompliceret type 2-diabetes. Derudover havde patienter med type 2-diabetes kompliceret med albuminuri eller retinopati højere venstre ventrikel masse og højere E/e* (et ekkokardiografisk mål for diastolisk funktion af venstre ventrikel) end patienter med ukompliceret type 2-diabetes. Vi fandt en signifikant sammenhæng mellem reduceret myokardie perfusions reserve og nedsat diastolisk funktion af venstre ventrikel. Endelig fandt vi, at øgede niveauer af biomarkøren fibroblast vækstfaktor-23, som tidligere er blevet forbundet med øget risiko for hjerte-kar sygdom og hjerte-kar dødelighed hos patienter både med og uden type 2-diabetes, var forbundet med et fald i myokardie perfusions reserve og reduceret maksimal myokardie perfusion under farmakologisk stress samt øget E/e*.Dette ph.d.-studie giver indsigt i, hvordan myokardie perfusionen ændres hos patienter med type 2-diabetes, og hvordan disse ændringer er relateret til de klassiske risikofaktorer og komplikationer ved type 2-diabetes. Derudover viser vores resultater en tilsyneladende sammenhæng mellem kardiel mikrovaskulær sygdom og udvikling af venstre ventrikel diastolisk dysfunktion, et nøglekarakteristikum for diabetisk kardiomyopati. Vores resultater afslører et behov for veldesignede prospektive kliniske forsøg for yderligere at undersøge, hvordan ændringer i den kardielle mikrocirkulation over tid påvirker hjertefunktionen, og risikoen for at udvikle diabetisk kardiomyopati hos patienter med type 2-diabetes. Patients with type 2 diabetes have an increased risk of developing heart failure independent of other risk factors, such as coronary artery disease and hypertension. This increased prevalence of heart failure in type 2 diabetes has led to the hypothesis, that a specific diabetic cardiomyopathy, characterized by concentric myocardial hypertrophy and diastolic dysfunction, exists. Alterations in the myocardial microcirculation and microvascular dysfunction has been suggested to play a role in the development of diabetic cardiomyopathy and heart failure in patients with type 2 diabetes, however, the exact mechanism of how type 2 diabetes can cause heart failure independent of other cardiovascular risk factors still remains partly unknown.In this PhD thesis we investigated how differences in the diabetic phenotype (diabetic complications, risk factors, anti-diabetes therapy, etc.) affects myocardial perfusion, as a measure of coronary microvascular disease, and if changes in cardiac structure and function in patients with type 2 diabetes is related to coronary microvascular disease, as a possible mechanistic pathway for the development of diabetic cardiomyopathy.To investigate this, 273 patients with type 2 diabetes and 25 control subjects without type 2 diabetes were included in a cross-sectional survey. All participants underwent clinical examination, blood and urinary sampling, echocardiography and advanced cardiac magnetic resonance imaging including mapping sequences for tissue characterization and full quantitative myocardial perfusion during both rest and pharmacological stress (adenosine 140 µg/kg/min). Blood- and urinary samples from all patients with type 2 diabetes were collected and transported to Region Zealand’s biobank for long time storage.We found that patients with type 2 diabetes had lower myocardial perfusion reserve when compared to control subjects, and that this reduction in myocardial perfusion reserve was caused by both an increase in myocardial blood flow during rest and reduced maximal myocardial blood flow during vasodilator stress. Patients with type 2 diabetes complicated with albuminuria or retinopathy had lower myocardial perfusion reserve and maximal myocardial blood flow during stress, compared to patients with uncomplicated type 2 diabetes. In addition, patients with type 2 diabetes complicated with albuminuria or retinopathy had higher left ventricular mass and E/e* (an echocardiographic measure of left ventricular diastolic function), than did patients with uncomplicated type 2 diabetes. We found a significant association between reduced myocardial perfusion reserve and impaired left ventricular diastolic function. Finally, we found that increased levels of the biomarker fibroblast growth factor-23, Martin Heyn Sørensen, 2020 4 which has previously been associated with cardiovascular morbidity and mortality in both patients with and without type 2 diabetes, were associated with a decrease in myocardial perfusion reserve and reduced maximal myocardial blood flow during stress as well as increased E/e*.In conclusion, this PhD study provides insight into how myocardial perfusion is altered in patients with type 2 diabetes and how these changes are related to the classic risk factors and complications in type 2 diabetes. Additionally, our data suggests an apparent link between coronary microvascular disease and cardiac diastolic dysfunction, a key characteristic in diabetic cardiomyopathy. Our findings reveal a need for well-designed longitudinal clinical trials, to further investigate how changes in the myocardial microcirculation over time, affects cardiac function and the risk of developing diabetic cardiomyopathy in patients with type 2 diabetes.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ University of Southe...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ University of Southe...arrow_drop_down
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Kjær, Per;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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    Authors: Cohen, Michael;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Elf, Nikolaj Frydensbjerg;

    Folke- og gymnasieskoler eksperimenter i disse år med at anskaffe mobiltelefoner til hele klasser. Målet er at eksperimentere med at integrere mobilen i undervisningen og skolekulturen mere bredt forstået. Men giver det egentlig mening i forhold til fagligheden? Er det noget eleverne er interesseret i? Er det noget lærerne er med på? Er det muligt inden for læreplanernes rammer, og hvad siger Undervisningsministeriet om den slags? Hvordan hænger ny mobilteknologi, didaktik og læring sammen? Hvilke barrierer vil en mobildidaktik møde i praksis? Hvad foregår der internationalt inden for dette forskningsområde? Med udgangspunkt i analyser af forsøgs- og udviklingsprojektet M-læring i gymnasiet, som finder sted i en handelsgymnasiumklasse på IBC i Kolding, hvor alle elever og lærere har fået iPhones, lægges der op til svar på disse spørgsmål. Der vil blive lagt særlig vægt på de fagdidaktiske forandringsprocesser der ser ud til at blive muliggjort i fag som dansk, engelsk, samfundsfag, matematik, afsætning og virksomhedsøkonomi. Samtidig sættes projektet ind i en bredere mediepædagogisk forståelsesramme. Oplægget hænger sammen med en efterfølgende workshop hvor lærere og elever fra iPhone-klassen på IBC præsenterer deres erfaringer. Som appetitvækker kan man læse en artikel i magasinet Systimes om projektet.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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    Authors: Ribers, Bjørn;
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    Authors: Rind Christensen, Poul;
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    Authors: Petersen, Michael Nebeling; Myong, Lene; Danbolt, Mathias; Bissenbakker, Mons;
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kempf, S. J.; Janik, Dirk; Barjaktarovic, Zarko; Braga-Tanaka III, I.; +5 Authors

    Accruing data indicate that radiation-induced consequences resemble pathologies of neurodegenerative diseases such as Alzheimer's. The aim of this study was to elucidate the effect on hippocampus of chronic low-dose-rate radiation exposure (1 mGy/day or 20 mGy/day) given over 300 days with cumulative doses of 0.3 Gy and 6.0 Gy, respectively. ApoE deficient mutant C57Bl/6 mouse was used as an Alzheimer's model. Using mass spectrometry, a marked alteration in the phosphoproteome was found at both dose rates. The radiation-induced changes in the phosphoproteome were associated with the control of synaptic plasticity, calcium-dependent signalling and brain metabolism. An inhibition of CREB signalling was found at both dose rates whereas Rac1-Cofilin signalling was found activated only at the lower dose rate. Similarly, the reduction in the number of activated microglia in the molecular layer of hippocampus that paralleled with reduced levels of TNFα expression and lipid peroxidation was significant only at the lower dose rate. Adult neurogenesis, investigated by Ki67, GFAP and NeuN staining, and cell death (activated caspase-3) were not influenced at any dose or dose rate. This study shows that several molecular targets induced by chronic low-dose-rate radiation overlap with those of Alzheimer's pathology. It may suggest that ionising radiation functions as a contributing risk factor to this neurodegenerative disease.

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    Oncotarget
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    ENEA Open Archive
    Article . 2016
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    Oncotarget; ENEA Open Archive
    Article . Other ORP type . 2016 . Peer-reviewed
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    Article . 2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Grønvold, Mogens; Christensen, Caroline Arnfeldt; Johnsen, Anna Thit;
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Ellegaard, Pernille Kempel;

    Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
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    Authors: Heyn Sørensen, Martin;

    Patienter med type 2-diabetes har en øget risiko for at udvikle hjertesvigt uafhængigt af andre risikofaktorer, såsom arteriosklerose og hypertension. Denne øgede forekomst af hjertesvigt hos patienter med type 2-diabetes har ført til hypotesen om, at der findes en specifik diabetisk kardiomyopati, kendetegnet ved koncentrisk myokardiehypertrofi og diastolisk dysfunktion. Ændringer i hjertets mikrocirkulation og mikrovaskulær dysfunktion i hjertets små kar spiller muligvis en rolle i udviklingen af diabetisk kardiomyopati og hjertesvigt hos patienter med type 2-diabetes, men den nøjagtige mekanisme for, hvordan type 2-diabetes kan forårsage hjertesvigt uafhængigt af andre kardiovaskulære risikofaktorer er fortsat ukendt.I denne ph.d.-afhandling undersøgte vi, hvordan forskelle i den diabetiske fænotype (diabetiske komplikationer, risikofaktorer, anti-diabetesbehandling osv.) påvirker perfusion i myokardiet, som et mål for kardiel mikrovaskulær sygdom, og om ændringer i hjertestruktur og funktion hos patienter med type 2-diabetes er relateret til kardiel mikrovaskulær sygdom, som en mulig mekanisme bag udviklingen af diabetisk kardiomyopati.For at undersøge dette blev 273 patienter med type 2-diabetes og 25 kontrolpersoner uden type 2-diabetes inkluderet i en tværsnitsundersøgelse. Alle deltagere gennemgik klinisk undersøgelse, blodog urinprøveudtagning, ekkokardiografi og avanceret magnetisk resonans scanning af hjertet, inklusive sekvenser for vævskarakterisering og fuld kvantitativ myokardie perfusion i hvile og under farmakologisk stress (adenosin 140 ug/kg/min). Blod- og urinprøver fra alle patienter med type 2-diabetes blev opsamlet og transporteret til Region Sjællands biobank for langtidsopbevaring.Vi fandt, at patienter med type 2-diabetes havde lavere myokardie perfusions reserve sammenlignet med kontrolpersoner, og at denne reduktion i myokardie perfusions reserve var forårsaget af både en Martin Heyn Sørensen, 2020 5 stigning i myokardie perfusion i hvile og reduceret maksimal myokardie perfusion under farmakologisk stress. Patienter med type 2-diabetes kompliceret med albuminuri eller retinopati havde lavere myokardie perfusions reserve og lavere maksimal myokardie perfusion under farmakologisk stress, sammenlignet med patienter med ukompliceret type 2-diabetes. Derudover havde patienter med type 2-diabetes kompliceret med albuminuri eller retinopati højere venstre ventrikel masse og højere E/e* (et ekkokardiografisk mål for diastolisk funktion af venstre ventrikel) end patienter med ukompliceret type 2-diabetes. Vi fandt en signifikant sammenhæng mellem reduceret myokardie perfusions reserve og nedsat diastolisk funktion af venstre ventrikel. Endelig fandt vi, at øgede niveauer af biomarkøren fibroblast vækstfaktor-23, som tidligere er blevet forbundet med øget risiko for hjerte-kar sygdom og hjerte-kar dødelighed hos patienter både med og uden type 2-diabetes, var forbundet med et fald i myokardie perfusions reserve og reduceret maksimal myokardie perfusion under farmakologisk stress samt øget E/e*.Dette ph.d.-studie giver indsigt i, hvordan myokardie perfusionen ændres hos patienter med type 2-diabetes, og hvordan disse ændringer er relateret til de klassiske risikofaktorer og komplikationer ved type 2-diabetes. Derudover viser vores resultater en tilsyneladende sammenhæng mellem kardiel mikrovaskulær sygdom og udvikling af venstre ventrikel diastolisk dysfunktion, et nøglekarakteristikum for diabetisk kardiomyopati. Vores resultater afslører et behov for veldesignede prospektive kliniske forsøg for yderligere at undersøge, hvordan ændringer i den kardielle mikrocirkulation over tid påvirker hjertefunktionen, og risikoen for at udvikle diabetisk kardiomyopati hos patienter med type 2-diabetes. Patients with type 2 diabetes have an increased risk of developing heart failure independent of other risk factors, such as coronary artery disease and hypertension. This increased prevalence of heart failure in type 2 diabetes has led to the hypothesis, that a specific diabetic cardiomyopathy, characterized by concentric myocardial hypertrophy and diastolic dysfunction, exists. Alterations in the myocardial microcirculation and microvascular dysfunction has been suggested to play a role in the development of diabetic cardiomyopathy and heart failure in patients with type 2 diabetes, however, the exact mechanism of how type 2 diabetes can cause heart failure independent of other cardiovascular risk factors still remains partly unknown.In this PhD thesis we investigated how differences in the diabetic phenotype (diabetic complications, risk factors, anti-diabetes therapy, etc.) affects myocardial perfusion, as a measure of coronary microvascular disease, and if changes in cardiac structure and function in patients with type 2 diabetes is related to coronary microvascular disease, as a possible mechanistic pathway for the development of diabetic cardiomyopathy.To investigate this, 273 patients with type 2 diabetes and 25 control subjects without type 2 diabetes were included in a cross-sectional survey. All participants underwent clinical examination, blood and urinary sampling, echocardiography and advanced cardiac magnetic resonance imaging including mapping sequences for tissue characterization and full quantitative myocardial perfusion during both rest and pharmacological stress (adenosine 140 µg/kg/min). Blood- and urinary samples from all patients with type 2 diabetes were collected and transported to Region Zealand’s biobank for long time storage.We found that patients with type 2 diabetes had lower myocardial perfusion reserve when compared to control subjects, and that this reduction in myocardial perfusion reserve was caused by both an increase in myocardial blood flow during rest and reduced maximal myocardial blood flow during vasodilator stress. Patients with type 2 diabetes complicated with albuminuria or retinopathy had lower myocardial perfusion reserve and maximal myocardial blood flow during stress, compared to patients with uncomplicated type 2 diabetes. In addition, patients with type 2 diabetes complicated with albuminuria or retinopathy had higher left ventricular mass and E/e* (an echocardiographic measure of left ventricular diastolic function), than did patients with uncomplicated type 2 diabetes. We found a significant association between reduced myocardial perfusion reserve and impaired left ventricular diastolic function. Finally, we found that increased levels of the biomarker fibroblast growth factor-23, Martin Heyn Sørensen, 2020 4 which has previously been associated with cardiovascular morbidity and mortality in both patients with and without type 2 diabetes, were associated with a decrease in myocardial perfusion reserve and reduced maximal myocardial blood flow during stress as well as increased E/e*.In conclusion, this PhD study provides insight into how myocardial perfusion is altered in patients with type 2 diabetes and how these changes are related to the classic risk factors and complications in type 2 diabetes. Additionally, our data suggests an apparent link between coronary microvascular disease and cardiac diastolic dysfunction, a key characteristic in diabetic cardiomyopathy. Our findings reveal a need for well-designed longitudinal clinical trials, to further investigate how changes in the myocardial microcirculation over time, affects cardiac function and the risk of developing diabetic cardiomyopathy in patients with type 2 diabetes.

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Kjær, Per;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Cohen, Michael;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Elf, Nikolaj Frydensbjerg;

    Folke- og gymnasieskoler eksperimenter i disse år med at anskaffe mobiltelefoner til hele klasser. Målet er at eksperimentere med at integrere mobilen i undervisningen og skolekulturen mere bredt forstået. Men giver det egentlig mening i forhold til fagligheden? Er det noget eleverne er interesseret i? Er det noget lærerne er med på? Er det muligt inden for læreplanernes rammer, og hvad siger Undervisningsministeriet om den slags? Hvordan hænger ny mobilteknologi, didaktik og læring sammen? Hvilke barrierer vil en mobildidaktik møde i praksis? Hvad foregår der internationalt inden for dette forskningsområde? Med udgangspunkt i analyser af forsøgs- og udviklingsprojektet M-læring i gymnasiet, som finder sted i en handelsgymnasiumklasse på IBC i Kolding, hvor alle elever og lærere har fået iPhones, lægges der op til svar på disse spørgsmål. Der vil blive lagt særlig vægt på de fagdidaktiske forandringsprocesser der ser ud til at blive muliggjort i fag som dansk, engelsk, samfundsfag, matematik, afsætning og virksomhedsøkonomi. Samtidig sættes projektet ind i en bredere mediepædagogisk forståelsesramme. Oplægget hænger sammen med en efterfølgende workshop hvor lærere og elever fra iPhone-klassen på IBC præsenterer deres erfaringer. Som appetitvækker kan man læse en artikel i magasinet Systimes om projektet.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao University of Southe...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Ribers, Bjørn;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao