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Evidence for Higgs boson decay to a pair of muons is presented. This result combines searches in four exclusive categories targeting the production of the Higgs boson via gluon fusion, via vector boson fusion, in association with a vector boson, and in association with a top quark-antiquark pair. The analysis is performed using proton-proton collision data at s√ = 13 TeV, corresponding to an integrated luminosity of 137 fb−1, recorded by the CMS experiment at the CERN LHC. An excess of events over the back- ground expectation is observed in data with a significance of 3.0 standard deviations, where the expectation for the standard model (SM) Higgs boson with mass of 125.38 GeV is 2.5. The combination of this result with that from data recorded at s√ = 7 and 8 TeV, corresponding to integrated luminosities of 5.1 and 19.7 fb−1, respectively, increases both the expected and observed significances by 1%. The measured signal strength, relative to the SM prediction, is 1.19+0.40−0.39(stat)+0.15−0.14(syst). This result constitutes the first evidence for the decay of the Higgs boson to second generation fermions and is the most precise measurement of the Higgs boson coupling to muons reported to date. Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS collaboration: et al. Peer reviewed

Measurements of the second Fourier harmonic coefficient (v2) of the azimuthal distributions of prompt and nonprompt D0 mesons produced in pp and pPb collisions are presented. Nonprompt D0 mesons come from beauty hadron decays. The data samples are collected by the CMS experiment at nucleon-nucleon center-of-mass energies of 13 and 8.16 TeV, respectively. In high multiplicity pp collisions, v2 signals for prompt charm hadrons are reported for the first time, and are found to be comparable to those for light-flavor hadron species over a transverse momentum (pT) range of 2–6 GeV. Compared at similar event multiplicities, the prompt D0 meson v2 values in pp and pPb collisions are similar in magnitude. The v2 values for open beauty hadrons are extracted for the first time via nonprompt D0 mesons in pPb collisions. For pT in the range of 2–5 GeV, the results suggest that v2 for nonprompt D0 mesons is smaller than that for prompt D0 mesons. These new measurements indicate a positive charm hadron v2 in pp collisions and suggest a mass dependence in v2 between charm and beauty hadrons in the pPb system. These results provide insights into the origin of heavy-flavor quark collectivity in small systems. Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); CERN; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias. CMS Collaboration: et al. Funded by SCOAP3. Peer reviewed

We consider the problem of computing optimal linear control policies for linear systems in finite-horizon. The states and the inputs are required to remain inside pre-specified safety sets at all times despite unknown disturbances. In this technical note, we focus on the requirement that the control policy is distributed, in the sense that it can only be based on partial information about the history of the outputs. It is well-known that when a condition denoted as Quadratic Invariance (QI) holds, the optimal distributed control policy can be computed in a tractable way. Our goal is to unify and generalize the class of information structures over which quadratic invariance is equivalent to a test over finitely many binary matrices. The test we propose certifies convexity of the output-feedback distributed control problem in finite-horizon given any arbitrarily defined information structure, including the cases of time varying communication networks and forgetting mechanisms. Furthermore, the framework we consider allows for including polytopic constraints on the states and the inputs in a natural way, without affecting convexity. IEEE Transactions on Automatic Control, 64 (12) ISSN:1558-2523 ISSN:0018-9286

Graph convolutional networks (GCNs) achieved promising performance in skeleton-based human action recognition by modeling a sequence of skeletons as a spatio-temporal graph. Most of the recently proposed GCN-based methods improve the performance by learning the graph structure at each layer of the network using a spatial attention applied on a predefined graph Adjacency matrix that is optimized jointly with model's parameters in an end-to-end manner. In this paper, we analyze the spatial attention used in spatio-temporal GCN layers and propose a symmetric spatial attention for better reflecting the symmetric property of the relative positions of the human body joints when executing actions. We also highlight the connection of spatio-temporal GCN layers employing additive spatial attention to bilinear layers, and we propose the spatio-temporal bilinear network (ST-BLN) which does not require the use of predefined Adjacency matrices and allows for more flexible design of the model. Experimental results show that the three models lead to effectively the same performance. Moreover, by exploiting the flexibility provided by the proposed ST-BLN, one can increase the efficiency of the model. Accepted by the 2021 International Joint Conference on Neural Networks (IJCNN 2021)

Genetically encodable fluorescent proteins have revolutionized biological imaging in vivo and in vitro. Since there are no other natural fluorescent tags with comparable features, the impact of fluorescent proteins for biological research cannot be overemphasized. Despite their importance, their photophysical properties, i.e., brightness, count-rate and photostability, are relatively poor compared to synthetic organic fluorophores or quantum dots. Intramolecular photostabilizers were recently rediscovered as an effective approach to improve photophysical properties. The approach uses direct conjugation of photostablizing compounds such as triplet-state quenchers or redox-active substances to an organic fluorophore, thereby creating high local concentrations of photostabilizer. Here, we introduce an experimental strategy to screen for the effects of covalently-linked photostabilizers on fluorescent proteins. We recombinantly produced a double cysteine mutant (A206C/L221C) of α-GFP for attachment of photostabilizer-maleimides on the ß-barrel in close proximity to the chromophore. Whereas labelling with photostabilizers such as Trolox, Nitrophenyl, and Cyclooctatetraene, which are often used for organic fluorophores, had no effect on α-GFP-photostability, a substantial increase of photostability was found upon conjugation of α-GFP to an azobenzene derivative. Although the mechanism of the photostabilizing effects remains to be elucidated, we speculate that the higher triplet-energy of azobenzene might be crucial for triplet-quenching of fluorophores in the near-UV and blue spectral range. Our study paves the way towards the development and design of a second generation of fluorescent proteins with photostabilizers placed directly in the protein barrel by methods such as unnatural amino acid incorporation.

Traffic-responsive signal control is a cost-effective and easy-to-implement network management strategy with high potential in improving performance in congested networks with dynamic characteristics. Max Pressure (MP) distributed controller gained significant popularity due to its theoretically proven ability of queue stabilization and throughput maximization under specific assumptions. However, its effectiveness under saturated conditions is questionable, while network-wide application is limited due to high instrumentation cost. Perimeter control (PC) based on the concept of the Macroscopic Fundamental Diagram (MFD) is a state-of-the-art aggregated strategy that regulates exchange flows between regions, in order to maintain maximum regional travel production and prevent over-saturation. Yet, homogeneity assumption is hardly realistic in congested states, thus compromising PC efficiency. In this paper, the effectiveness of network-wide, parallel application of PC and MP embedded in a two-layer control framework is assessed with mesoscopic simulation. Aiming at reducing implementation cost of MP without significant performance loss, we propose a method to identify critical nodes for partial MP deployment. A modified version of Store-and-forward paradigm incorporating finite queue and spill-back consideration is used to test different configurations of the proposed framework, for a real large-scale network, in moderately and highly congested scenarios. Results show that: (i) combined control of MP and PC outperforms separate MP and PC applications in both demand scenarios; (ii) MP control in reduced critical node sets leads to similar or even better performance compared to full-network implementation, thus allowing for significant cost reduction; iii) the proposed control schemes improve system performance even under demand fluctuations of up to 20% of mean. arXiv

National audience; Soda taxes aim to reduce excessive sugar consumption. Policymakers highlight the young, particularly from poor backgrounds, and high sugar consumers as groups whose behavior they would most like to influence. There are also concerns about the policy being regressive. We assess who are most impacted by soda taxes. We estimate demand using micro longitudinal data covering on-the-go purchases, and exploit the panel dimension to estimate individual specific preferences. We relate these preferences and counterfactual predictions to individual characteristics and show that soda taxes are relatively effective at targeting the sugar intake of the young, are less successful at targeting the intake of those with high total dietary sugar, and are unlikely to be strongly regressive especially if consumers benefit from averted internalities.