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93 Research products, page 1 of 10

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  • Open Access English
    Authors: 
    Linda Cerofolini; Stefano Giuntini; Letizia Barbieri; Matteo Pennestri; Anna Codina; Marco Fragai; Lucia Banci; Enrico Luchinat; Enrico Ravera;
    Country: Italy
    Project: EC | West-Life (675858), EC | iNEXT (653706), EC | INSTRUCT-ULTRA (731005)

    Abstract FlowNMR has the aim of continuously monitoring processes that occur in conditions that are not compatible with being carried out within a closed tube. However, it is sample intensive and not suitable for samples, such as proteins or living cells, that are often...

  • Open Access
    Authors: 
    C.O.S. Sorzano; F. de Isidro-Gomez; E. Fernández-Giménez; David Herreros; Sergio Marco; José María Carazo; C. Messaoudi;
    Publisher: Elsevier
    Country: Spain
    Project: EC | iNEXT-Discovery (871037), EC | IMpaCT (857203), EC | EOSC-Life (824087), EC | HighResCells (810057), EC | CORBEL (654248), EC | INSTRUCT-ULTRA (731005), EC | EOSC-synergy (857647)

    Electron tomography is a technique to obtain three-dimensional structural information of samples. However, the technique is limited by shifts occurring during acquisition that need to be corrected before the reconstruction process. In 2009, we proposed an approach for p...

  • Publication . Other literature type . 2019
    Open Access
    Authors: 
    AARC Consortium; AARC Community; Appint Members;
    Publisher: Zenodo
    Project: EC | AARC2 (730941)

    This document defines a generic browser-based protocol for conveying - to services - hints about the IdPs or IdP-SP-proxies that should be used for authenticating the principal. This protocol, colloquially referred to as Identity Provider (IdP) hinting, can greatly simp...

  • Publication . Article . 2018
    Open Access English
    Authors: 
    Andreini, Claudia; Putignano, Valeria; Rosato, Antonio; Banci, Lucia;
    Country: Italy
    Project: EC | West-Life (675858)

    Organisms from all kingdoms of life use iron-proteins in a multitude of functional processes. We applied a bioinformatics approach to investigate the human portfolio of iron-proteins. We separated iron-proteins based on the chemical nature of their metal-containing cofa...

  • Open Access
    Authors: 
    van Zundert, G. C P; Trellet, M.; Schaarschmidt, J.; Kurkcuoglu Soner, Zeynep; David, M.; Verlato, M.; Rosato, A.; Bonvin, A. M J J; Sub NMR Spectroscopy; NMR Spectroscopy;
    Publisher: Elsevier BV
    Countries: Italy, Netherlands
    Project: EC | EGI-Engage (654142), EC | West-Life (675858), EC | INDIGO-DataCloud (653549), NWO | Zooming into large assemb... (2300165908), EC | BioExcel (675728)

    Structure determination of complex molecular machines requires a combination of an increasing number of experimental methods with highly specialized software geared toward each data source to properly handle the gathered data. Recently, we introduced the two software pa...

  • Open Access
    Authors: 
    Argenzio, Elisabetta; Kedziora, Katarzyna M.; Nahidiazar, Leila; Isogai, Tadamoto; Perrakis, Anastassis; Jalink, Kees; Moolenaar, Wouter H.; Innocenti, Metello;
    Publisher: bioRxiv
    Project: EC | WENMR (261572), EC | West-Life (675858)

    AbstractCLIC4 is a cytosolic protein implicated in diverse actin-based processes, including integrin trafficking, cell adhesion and tubulogenesis. CLIC4 is rapidly recruited to the plasma membrane by G12/13-coupled receptor agonists and then partly co-localizes with β1 ...

  • Open Access
    Authors: 
    Rodríguez-Arce, Irene; Al-Jubair, Tamim; Euba, Begoña; Fernández-Calvet, Ariadna; Gil-Campillo, Celia; Martí, Sara; Törnroth-Horsefield, Susanna; Riesbeck, Kristian; Garmendia, Junkal;
    Publisher: Informa UK Limited
    Countries: Denmark, Spain
    Project: EC | EOSC-hub (777536), EC | WENMR (261572), EC | West-Life (675858)

    Nutrient iron sequestration is the most significant form of nutritional immunity and causes bacterial pathogens to evolve strategies of host iron scavenging. Cigarette smoking contains iron particulates altering lung and systemic iron homeostasis, which may enhance colo...

  • Open Access English
    Authors: 
    Julie A. McMurry; Nick Juty; Niklas Blomberg; Tony Burdett; Tom Conlin; Nathalie Conte; Mélanie Courtot; John Deck; Michel Dumontier; Donal Fellows; +34 more
    Publisher: Public Library of Science (PLoS)
    Countries: Germany, Netherlands, Denmark, United Kingdom, United Kingdom, United States
    Project: NIH | BioCADDIE: Biomedical and... (1U24AI117966-01), WT , NIH | Center for Expanded Data ... (1U54AI117925-01), EC | ISBE (312455), EC | DDMORE (115156), UKRI | Enriching Metabolic PATHw... (BB/M006891/1), UKRI | Continued development of ... (BB/K019783/1), NIH | UniProt: A centralized pr... (3U41HG007822-04S1), UKRI | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), EC | DIACHRON (601043),...

    AbstractIn many disciplines, data is highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar that make inte...

  • Open Access English
    Authors: 
    Cerofolini, Linda; Giuntini, Stefano; Carlon, Azzurra; Ravera, Enrico; Calderone, Vito; Fragai, Marco; Parigi, Giacomo; Luchinat, Claudio;
    Country: Italy
    Project: EC | West-Life (675858), EC | WENMR (261572), EC | iNEXT (653706)

    Resonance assignment and structural characterization of pharmacologically relevant proteins promise to improve understanding and safety of these proteins by rational design. However, the PEG coating that is used to evade the immune system also causes these molecules to ...

  • Open Access
    Authors: 
    Young, Jasmine Y; Westbrook, John D; Feng, Zukang; Peisach, Ezra; Persikova, Irina; Sala, Raul; Sen, Sanchayita; Berrisford, John M; Swaminathan, G Jawahar; Oldfield, Thomas J; +41 more
    Project: WT , NHMRC | Genetic and Biochemical A... (284209), NSF | PDB Management by the Res... (1338415), UKRI | BioSolr: addressing the c... (BB/M013146/1), UKRI | Supporting archival and d... (BB/M020347/1), UKRI | Validation of biomacromol... (BB/J007471/1), NHMRC | Molecular control of cell... (104948), UKRI | Expanding the knowledge o... (BB/M011674/1), NIH | The BMRB as an evolving r... (3R01GM109046-01S1), UKRI | An Greatly Expanded CATH-... (BB/K020013/1),...

    Abstract The Protein Data Bank (PDB) is the single global repository for experimentally determined 3D structures of biological macromolecules and their complexes with ligands. The worldwide PDB (wwPDB) is the international collaboration that manages the PDB archive acco...